Oral microbiota mediates the association of healthy dietary patterns with lower risk of advanced cardiovascular-kidney-metabolic syndrome [0.03%]
口腔微生物介导了健康饮食模式与降低心血管-肾脏-代谢综合征风险之间的关系
Weitao Su,Yayuan Mei,Ming Yang et al.
Weitao Su et al.
Objectives: Existing evidence links diet and the oral microbiota to individual cardiovascular, kidney, and metabolic conditions, but these relationships have not been extended to the progressive stages of cardiovascular-k...
Defining a ketone threshold for weight loss: evidence from 14 day daily β-hydroxybutyrate monitoring in 217 subjects on a ketogenic diet [0.03%]
生酮饮食受试者短期β-羟基丁酸水平变化与体重的相关性：一项为期两周的纵向研究
Antonio Paoli,Giuseppe Cerullo,Samuele Paoli et al.
Antonio Paoli et al.
Background: The ketogenic diet (KD) is a widely used nutritional intervention for weight loss. The beneficial effects of the KD are intrinsically linked to the state of physiological ketosis, where ketone bodies (KBs) rai...
Reversal of canonical Wnt/β-catenin signaling pathway attenuates gestational diabetes mellitus-induced offspring cardiac hypertrophy: mechanistic insights into pathological remodeling [0.03%]
经典Wnt/β-catenin信号通路逆转缓解妊娠糖尿病诱发的心脏肥厚：病理重塑机制研究新进展
Xun Yuan,Yuejiang Jiao,Zexin Huang et al.
Xun Yuan et al.
Background: Gestational diabetes mellitus (GDM), a prevalent prenatal metabolic disorder characterized by hyperglycemia occurring in approximately 9.2% of pregnancies globally, imposes significant cardiovascular risks on ...
GULP1 enhances GLUT4 translocation by counteracting ACAP1-ARF6 inhibition [0.03%]
GULP1通过对抗ACAP1-ARF6抑制来增强GLUT4转位
Xin Wen,Jin Mei,Yidan Jiang et al.
Xin Wen et al.
Objectives: The molecular underpinnings of obesity-induced insulin resistance, a key driver of type 2 diabetes mellitus (T2DM), remain incompletely understood, limiting targeted therapies. While our prior work revealed th...
Beneficial effects of Chlorella species supplementation in the general population: a GRADE-assessed systematic review and dose-response meta-analysis [0.03%]
小球藻属补充剂对普通人群的有益作用：系统评价和剂量反应meta分析（GRADE评估）
Helia Mardani,Mohammad Amin Karimi,Mohammad Sharifi et al.
Helia Mardani et al.
This systematic review and meta-analysis aimed to evaluate the potential benefits of Chlorella supplementation in the general population, with a focus on its impact across a broad spectrum of health-related biomarkers and clinical parameter...
Anh Ngan Nguyen,Oscar Osorio-Perez,David Jackemeyer et al.
Anh Ngan Nguyen et al.
Background/objective: We present the first receiver operating characteristic (ROC) diagnostic analysis of skin-excreted acetone as a biomarker of ketosis. ...
Redox and bioenergetic modulation by plumbagin attenuated neuropathic allodynia in mice with diet-induced diabetes [0.03%]
氧化还原和生物能量调节剂朴金通过减少糖尿病引起的神经病理性疼痛起作用
Youya Fan,Yangui Wang,Wugeng Cui et al.
Youya Fan et al.
Background: Painful diabetic neuropathy represents a substantial health burden, afflicting approximately 30% of individuals with diabetes. Currently available neuropathic pain medications exhibit only limited efficacy, ar...
Association between probiotic, prebiotic, and yogurt consumption and colorectal cancer: real-world evidence from the US NHANES [0.03%]
益生菌、益生元和酸奶消费与结直肠癌的关联：来自美国NHANES的真实世界证据
Ching-Wei Tu,Ho-Li Wang
Ching-Wei Tu
Background/objectives: Colorectal cancer (CRC) is influenced by genetic, environmental, and dietary factors, with increasing evidence highlighting the role of the gut microbiota in its development. Probiotics, prebiotics,...
Plasma exosome-derived miRNA-887-5p alleviates high glucose- and lipid-induced endothelial cell dysfunction [0.03%]
血浆外泌体衍生的miRNA-887-5p缓解高糖和脂质诱导的内皮细胞功能障碍
Fangfang Xu,Fang Chen,Hui Xiao et al.
Fangfang Xu et al.
Background: Identifying differentially expressed miRNAs in plasma-derived exosomes associated with type 2 diabetes mellitus (T2DM) complicated by atherosclerosis (AS) and elucidating their roles in high-glucose/high-lipid...
Subgroup-specific cardiovascular effects of intensive lifestyle intervention: a causal forest analysis in adults with type 2 diabetes and overweight/obesity [0.03%]
针对不同亚群的强化生活方式干预的心血管效应：成人2型糖尿病及超重或肥胖患者的因果森林分析
Xingfeng Xu,Jiangjie Lei,Lixiang He et al.
Xingfeng Xu et al.
Objective: To evaluate the heterogeneity of treatment effects (HTEs) of intensive lifestyle intervention (ILI) in adults with type 2 diabetes and overweight/obesity, and identify a subgroup with greater cardiovascular ben...