Alterations in cyclic nucleotide phosphodiesterase activities in omental and subcutaneous adipose tissues in human obesity [0.03%]
人类肥胖患者大网膜及皮下脂肪组织环核苷酸磷酸二酯酶活性的改变
B Omar,E Banke,M Ekelund et al.
B Omar et al.
Objective: To elucidate the activity and expression of cyclic nucleotide phosphodiesterase (PDE) families in omental (OM) and subcutaneous (SC) adipose tissue and adipocytes, and to study alterations in their activity in ...
Differential effects of saturated versus unsaturated dietary fatty acids on weight gain and myocellular lipid profiles in mice [0.03%]
饱和与不饱和膳食脂肪酸对小鼠体重增加和肌细胞脂质谱的差异化作用
S Timmers,J de Vogel-van den Bosch,N de Wit et al.
S Timmers et al.
Objective: In conditions of continuous high-fat (HF) intake, the degree of saturation of the fatty acids (FAs) in the diet might have a crucial role in the onset of obesity and its metabolic complications. In particular, ...
Insulin detemir attenuates food intake, body weight gain and fat mass gain in diet-induced obese Sprague-Dawley rats [0.03%]
insulin detemir能降低饮食诱导的sprague-dawley大鼠肥胖表型中的食物摄入量、体重增加和脂肪质量增加
J M Rojas,R L Printz,K D Niswender
J M Rojas
Objective: Initiation and intensification of insulin therapy commonly causes weight gain, a barrier to therapy. A contrasting body of evidence indicates that insulin functions as an adiposity negative feedback signal and ...
Metformin mitigates the impaired development of skeletal muscle in the offspring of obese mice [0.03%]
二甲双胍可通过改善肥胖小鼠后代肌纤维类型分布促进其骨骼肌发育
J F Tong,X Yan,J X Zhao et al.
J F Tong et al.
Background: Maternal obesity is linked with offspring obesity and type 2 diabetes. Skeletal muscle (SM) insulin resistance is central to the development of diabetes. Adenosine monophosphate (AMP)-activated protein kinase ...
Asian women have greater abdominal and visceral adiposity than Caucasian women with similar body mass index [0.03%]
与具有相似身体质量指数的高加索女性相比，亚洲女性腹部及内脏脂肪含量更高
U Lim,T Ernst,S D Buchthal et al.
U Lim et al.
Background: In the Multiethnic Cohort Study, Japanese Americans (JA) have lower mean body mass index (BMI) compared with Caucasians, but show a higher waist-to-hip ratio at similar BMI values and a greater risk of diabete...
Acylation stimulating protein reduction precedes insulin sensitization after BPD-DS bariatric surgery in severely obese women [0.03%]
重度肥胖女性在BPD-DS代谢手术后ASPN降低先于胰岛素敏感性提升
M N Munkonda,J Martin,P Poirier et al.
M N Munkonda et al.
Objective: The mechanisms involved in early resolution of insulin resistance and type 2 diabetes mellitus after biliopancreatic diversion with duodenal switch (BPD-DS) surgery are still unknown. We evaluated early effects...
Comparison of the effects of 52 weeks weight loss with either a high-protein or high-carbohydrate diet on body composition and cardiometabolic risk factors in overweight and obese males [0.03%]
比较高蛋白和高碳水化合物减肥饮食对超重及肥胖男性身体组成和心血管代谢危险因素长期影响的对照研究
T P Wycherley,G D Brinkworth,P M Clifton et al.
T P Wycherley et al.
Background: A high-protein (HP), low-fat weight-loss diet may be advantageous for improving cardiometabolic health outcomes and body composition. To date, only limited research has been conducted in male participants. ...
Impact of body mass index on diastolic function in patients with normal left ventricular ejection fraction [0.03%]
身体质量指数对正常左心室射血分数患者的舒张功能的影响
W Aljaroudi,C Halley,P Houghtaling et al.
W Aljaroudi et al.
Background: Obesity is a major public health epidemic and is associated with increased risk of heart failure and mortality. We evaluated the impact of body mass index (BMI) on the prevalence of diastolic dysfunction (DD)....
Visceral adipose tissue, but not waist circumference is a better measure of metabolic risk in Singaporean Chinese and Indian men [0.03%]
内脏脂肪组织比腰围是评估新加坡华人和印度人代谢风险的更好指标
A C Ng,D C Wai,E S Tai et al.
A C Ng et al.
Objectives: Visceral adipose tissue (VAT) is an independent risk factor in cardiometabolic diseases and is commonly measured by computed tomography (CT). It is measured clinically by waist circumference (WC). The L4/5 int...
Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice [0.03%]
ω-3多不饱和脂肪酸可保存2型糖尿病小鼠的视网膜功能
P Sapieha,J Chen,A Stahl et al.
P Sapieha et al.
Objective: Diabetic retinopathy (DR) is associated with hyperglycemia-driven microvascular pathology and neuronal compromise in the retina. However, DR is also linked to dyslipidemia. As omega-3 (ω-3) polyunsaturated fat...