Intermittent hypoxia-induced rat pancreatic β-cell apoptosis and protective effects of antioxidant intervention [0.03%]
间歇性低氧诱发的胰岛β细胞凋亡及抗氧化干预的保护效应
Y Fang,Q Zhang,J Tan et al.
Y Fang et al.
Purpose: Obstructive sleep apnea hypopnea syndrome (OSAHS), a common sleep and breathing disorder, is independently associated with metabolic dysfunction, including impaired glucose tolerance and insulin resistance. Inter...
Pilot randomized trial demonstrating reversal of obesity-related abnormalities in reward system responsivity to food cues with a behavioral intervention [0.03%]
一项试点随机试验：通过行为干预逆转与肥胖相关的奖赏系统对食物线索的反应异常
T Deckersbach,S K Das,L E Urban et al.
T Deckersbach et al.
Objectives: Obesity is associated with hyperactivation of the reward system for high-calorie (HC) versus low-calorie (LC) food cues, which encourages unhealthy food selection and overeating. However, the extent to which t...
Circulating adiponectin levels and risk of type 2 diabetes in the Japanese [0.03%]
日本人群循环脂联素水平与2型糖尿病发病风险的关系
S Yamamoto,Y Matsushita,T Nakagawa et al.
S Yamamoto et al.
Background: Adiponectin has anti-inflammatory and insulin-sensitizing properties. Prospective studies have consistently shown a lower risk of type 2 diabetes among those with higher circulating adiponectin levels. ...
Effect of short chain fatty acids on the expression of free fatty acid receptor 2 (Ffar2), Ffar3 and early-stage adipogenesis [0.03%]
短链脂肪酸对自由脂肪酸受体2(Ffar2)、Ffar3表达及早期阶段促脂生成的作用研究
G Frost,Z Cai,M Raven et al.
G Frost et al.
Adipose tissue has a major influence on insulin sensitivity. Stimulation of free fatty acid receptor 2 (FFAR2) has been proposed to influence adipocyte differentiation. We hypothesised that exposing preadipocytes to short chain fatty acids ...
Long-term changes in the ghrelin-CB1R axis associated with the maintenance of lower body weight after sleeve gastrectomy [0.03%]
袖状胃切除术后维持较低体重与ghreline-CB1R轴的长期变化关系
C Fedonidis,N Alexakis,X Koliou et al.
C Fedonidis et al.
Objectives: In the hypothalamus, the molecular actions of receptors for growth hormone secretagogue (ghrelin) receptor-GHSR, leptin receptor-b (LEPRb), Melanocortin-4 receptor (MC4R) and Cannabinoid-1 receptor (CB1R) regu...
Specific appetite, energetic and metabolomics responses to fat overfeeding in resistant-to-bodyweight-gain constitutional thinness [0.03%]
具有体重增加抵抗型体质的消瘦者脂肪过量摄入后的食欲、能量和代谢组学特征反应
N Germain,B Galusca,D Caron-Dorval et al.
N Germain et al.
Background: Contrasting with obesity, constitutional thinness (CT) is a rare condition of natural low bodyweight. CT exhibits preserved menstruation in females, no biological marker of undernutrition, no eating disorders ...
Tofogliflozin, a sodium/glucose cotransporter 2 inhibitor, attenuates body weight gain and fat accumulation in diabetic and obese animal models [0.03%]
托格列氟辛，一种钠/葡萄糖共转运蛋白2抑制剂，在糖尿病和肥胖动物模型中可减轻体重增加和脂肪积累
M Suzuki,M Takeda,A Kito et al.
M Suzuki et al.
Objective: Tofogliflozin, a highly selective inhibitor of sodium/glucose cotransporter 2 (SGLT2), induces urinary glucose excretion (UGE), improves hyperglycemia and reduces body weight in patients with Type 2 diabetes (T...
Effects of duodenal switch alone or in combination with sleeve gastrectomy on body weight and lipid metabolism in rats [0.03%]
单纯或者联合袖状胃切除术对断食大鼠体重及血脂代谢的影响
O A Gudbrandsen,Y Kodama,S A Mjøs et al.
O A Gudbrandsen et al.
Background: A combined procedure of sleeve gastrectomy and duodenal switch (SG+DS) has been applied to the treatment of super obesity. The aim of the present study was to test whether duodenal switch alone (DS) leads to s...
Effect of chronic coffee consumption on weight gain and glycaemia in a mouse model of obesity and type 2 diabetes [0.03%]
慢性咖啡摄入对肥胖和2型糖尿病小鼠模型体重增加和糖代谢的影响
I Rustenbeck,V Lier-Glaubitz,M Willenborg et al.
I Rustenbeck et al.
Objective: Epidemiological evidence shows that chronic coffee consumption in humans is correlated with a lower incidence of type 2 diabetes mellitus. For the experimental exploration of the underlying mechanisms, this eff...
Correlation network analysis reveals relationships between diet-induced changes in human gut microbiota and metabolic health [0.03%]
关联网络分析揭示了饮食诱导的人体肠道菌群变化与代谢健康之间的关系
T Kelder,J H M Stroeve,S Bijlsma et al.
T Kelder et al.
Background: Recent evidence suggests that the gut microbiota plays an important role in human metabolism and energy homeostasis and is therefore a relevant factor in the assessment of metabolic health and flexibility. Und...