Role of branched-chain amino acid metabolism in the pathogenesis of obesity and type 2 diabetes-related metabolic disturbances BCAA metabolism in type 2 diabetes [0.03%]
支链氨基酸代谢在肥胖及2型糖尿病相关代谢紊乱中的作用机制研究
Froukje Vanweert,Patrick Schrauwen,Esther Phielix
Froukje Vanweert
Branched-chain amino acid (BCAA) catabolism has been considered to have an emerging role in the pathogenesis of metabolic disturbances in obesity and type 2 diabetes (T2D). Several studies showed elevated plasma BCAA levels in humans with i...
Interpretable machine learning-derived nomogram model for early detection of diabetic retinopathy in type 2 diabetes mellitus: a widely targeted metabolomics study [0.03%]
用于2型糖尿病患者早期检测糖尿病视网膜病变的可解释机器学习派生的计算计模型：一项广泛目标代谢组学研究
Jushuang Li,Chengnan Guo,Tao Wang et al.
Jushuang Li et al.
Objective: Early identification of diabetic retinopathy (DR) is key to prioritizing therapy and preventing permanent blindness. This study aims to propose a machine learning model for DR early diagnosis using metabolomics...
Association between circulating 25-hydroxyvitamin D and cardiometabolic risk factors in adults in rural and urban settings [0.03%]
城乡成人血液循环中的25-羟基维生素D与心血管代谢危险因素的关系
Camille M Mba,Albert Koulman,Nita G Forouhi et al.
Camille M Mba et al.
Background: An inverse association between vitamin D status and cardiometabolic risk has been reported but this relationship may have been affected by residual confounding from adiposity and physical activity due to impre...
Folic acid effect on homocysteine, sortilin levels and glycemic control in type 2 diabetes mellitus patients [0.03%]
叶酸对2型糖尿病患者同型半胱氨酸、分拣蛋白水平及血糖控制的影响
Noha M El-Khodary,Hossam Dabees,Rehab H Werida
Noha M El-Khodary
Aim: The present study aimed to determine the folic acid supplement (FAS) effects on serum homocysteine and sortilin levels, glycemic indices, and lipid profile in type II diabetic patients. ...
Randomized Controlled Trial
Nutrition & diabetes. 2022 Jun 22;12(1):33. DOI:10.1038/s41387-022-00210-6 2022
The role of pancreas to improve hyperglycemia in STZ-induced diabetic rats by thiamine disulfide [0.03%]
维生素泛酸脑胰腺在链脲佐菌素诱导的糖尿病大鼠中的降糖机制研究
Mahtab Ghanbari Rad,Mohammadreza Sharifi,Rokhsareh Meamar et al.
Mahtab Ghanbari Rad et al.
Background: The present study investigated the effect of thiamine disulfide (TD) on the pancreas in terms of hyperglycemia improvement and insulin sensitivity increase in diabetic male rats. We also aimed to study the fun...
Is vascular insulin resistance an early step in diet-induced whole-body insulin resistance? [0.03%]
血管胰岛素抵抗是饮食诱导的全身胰岛素抵抗的早期阶段吗？
Lauren Carmichael,Michelle A Keske,Andrew C Betik et al.
Lauren Carmichael et al.
There is increasing evidence that skeletal muscle microvascular (capillary) blood flow plays an important role in glucose metabolism by increasing the delivery of glucose and insulin to the myocytes. This process is impaired in insulin-resi...
Changes in adiponectin:leptin ratio among older adults with obesity following a 12-month exercise and diet intervention [0.03%]
肥胖老年人在进行为期一年的运动和饮食干预后血清脂联素与瘦素比值的变化趋势分析
Katelyn E Senkus,Kristi M Crowe-White,Anneliese C Bolland et al.
Katelyn E Senkus et al.
Background: Excess adiposity is characterized by alterations in adipokine secretion such that circulating leptin concentrations are increased with reductions in adiponectin. An emerging biomarker for the assessment of thi...
Randomized Controlled Trial
Nutrition & diabetes. 2022 Jun 2;12(1):30. DOI:10.1038/s41387-022-00207-1 2022
Association between muscle mass and diabetes prevalence independent of body fat distribution in adults under 50 years old [0.03%]
肌肉量与成人糖尿病患病率之间的关系不受体脂分布影响（不足50岁人群）
Melanie S Haines,Aaron Leong,Bianca C Porneala et al.
Melanie S Haines et al.
Background/objectives: Although relatively less muscle mass has been associated with greater diabetes prevalence, whether there is an association between muscle mass and diabetes prevalence independent of body fat distrib...
Response of blood glucose and GLP-1 to different food temperature in normal subject and patients with type 2 diabetes [0.03%]
正常人和2型糖尿病患者对不同温度食物血糖及GLP-1的反应
Yun Hu,Peng Zhang,Bo Ding et al.
Yun Hu et al.
Background: Eating behavior is a major factor in type 2 diabetes. We investigated the different responses of glucose-regulating hormones to cold and hot glucose solutions in normal subjects and patients with type 2 diabet...
Identification and epidemiological characterization of Type-2 diabetes sub-population using an unsupervised machine learning approach [0.03%]
基于无监督机器学习方法的2型糖尿病亚群的识别及流行病学特征分析
Saptarshi Bej,Jit Sarkar,Saikat Biswas et al.
Saptarshi Bej et al.
Background: Studies on Type-2 Diabetes Mellitus (T2DM) have revealed heterogeneous sub-populations in terms of underlying pathologies. However, the identification of sub-populations in epidemiological datasets remains une...