Improving the oral bioavailability and anti-inflammatory potential of clove oil-derived β-caryophyllene with a self-nanoemulsifying drug delivery system [0.03%]
利用自行纳米乳化给药系统改善肉桂油衍生物β- Caryophyllene的口服生物利用度和抗炎潜力
Any Carolina Chagas-Ameida,Ana Paula Ames-Sibin,Juliana Cristina Castro et al.
Any Carolina Chagas-Ameida et al.
Objectives: β-Caryophyllene (β-Cary) is known for its anti-inflammatory properties and offers a promising avenue for drug development. This study prepared a lipid-based self-emulsifying system containing clove oil-deriv...
Effect of pigment epithelium-derived factor on prostaglandin E2 receptors (EP2/EP4) in glucocorticoid-induced osteoporosis in rats [0.03%]
色素上皮衍生因子对糖皮质激素诱导的骨质疏松大鼠前列腺素E2受体（EP2/EP4）效应的影响
Zerrin Kutlu,Zekai Halici,Fatih Alper et al.
Zerrin Kutlu et al.
Objectives: This study investigated the effects of pigment epithelium-derived factor (PEDF) on bone homeostasis in a glucocorticoid-induced osteoporosis (GIOP) rat model, focusing on prostaglandin E2 receptors EP2 and EP4...
Effects of mesenchymal stem cell exosomes on trabecular meshwork cells via the NRF2 pathway [0.03%]
外源性间充质干细胞通过NRF2通路调控小梁细胞抗氧化能力及增殖作用研究
Li Xu,Peng Xu,Na Song et al.
Li Xu et al.
Objectives: Increased intraocular pressure (IOP) is a significant risk factor for primary open-angle glaucoma (POAG). Physiologically, the trabecular meshwork (TM) controls IOP and the secretion of aqueous humor. A change...
The stereoselective pharmacokinetics of bupivacaine after racemate, and the effects of high-fat diet and sex in Sprague-Dawley rats [0.03%]
布比卡因外消旋体的立体选择性药代动力学及其在Sprague-Dawley大鼠中的高脂饮食和性别影响
Shamima Parvin,Neal M Davies,John R Ussher et al.
Shamima Parvin et al.
Objectives: The primary aim was to characterize the influence of diet-induced obesity on the stereoselective pharmacokinetics of racemic bupivacaine in male and female rats. ...
In vitro assessment of P-glycoprotein-mediated antiseizure medications efflux in a blood-brain barrier cell model [0.03%]
体外血脑屏障细胞模型中P-糖蛋白介导的抗癫痫药物外排评估
Priyanka Rani Paul,Shivangi Bora,Ankit Srivastava et al.
Priyanka Rani Paul et al.
Objectives: Drug-resistant epilepsy affects 30% of patients, where antiseizure medications (ASMs) are non-effective. A possible mechanism is the presence of the P-glycoprotein (P-gp) transporter in the blood-brain barrier...
Eudragit S100-coated liposomes: a pH-responsive strategy to overcome dabigatran etexilate's oral bioavailability challenge [0.03%]
用于克服达比加群酯口服生物利用度难题的pH响应策略：Eudragit S100肠溶脂质体包裹技术
Maged K Elsayad,Abdulsalam M Kassem,Elsaied H Barakat et al.
Maged K Elsayad et al.
Objectives: Dabigatran etexilate (DAB), a direct thrombin inhibitor, exhibits limited oral bioavailability (6%-7%), mostly attributable to pH-dependent solubility. To address this issue, Eudragit S100 (EU)-coated liposome...
Taoren Honghua Jian improves ferroptosis-mediated myocardial damage following myocardial infarction via Nrf2-dependent enhancement of GPX4/FSP1 [0.03%]
桃仁红花煎通过Nrf2依赖性增强GPX4/FSP1改善心肌梗死后铁死亡介导的心肌损伤
Guo-Yong Zhang,Feng Zhang,Ling-Peng Xie et al.
Guo-Yong Zhang et al.
Objectives: Myocardial infarction (MI) remains a leading cause of global mortality, and the inhibition of ferroptosis has cardioprotective potential. Taoren Honghua Jian (TRHHJ) has been used clinically to improve cardiov...
Novel molecular biomarkers in kidney diseases: bridging the gap between early detection and clinical implementation [0.03%]
肾脏疾病的新型分子生物标志物：弥合早期检测与临床应用之间的差距
Bhavana Bagdaram Choudhary,Bhupendra Puri,Anil Bhanudas Gaikwad
Bhavana Bagdaram Choudhary
Background: Kidney diseases affect over 850 million people globally and are a significant cause of morbidity and mortality. Traditional biomarkers like serum creatinine, blood urea nitrogen, and proteinuria have limited s...
Human epidermal growth factor receptor 2 as a target of 1,2,3,4,6-penta-O-galloyl-β-d-glucose in colon cancer [0.03%]
1,2,3,4,6-五没食子酰葡萄糖通过靶向人表皮生长因子受体2抑制结肠癌干性细胞属性
Huihai Yang,Grace Gar-Lee Yue,Ping-Chung Leung et al.
Huihai Yang et al.
Objectives: Although HER2 overexpression is observed in only 2%-3% of colorectal cancer (CRC) patients, its amplification can function as a compensatory mechanism that drives CRC resistance to targeted therapy. 1,2,3,4,6-...
Investigating the nitric oxide pathway stimulated by rosuvastatin on the pathological effects of renal ischemia-reperfusion in rats [0.03%]
rosuvastatin对大鼠肾缺血再灌注损伤的病理效应及NO信号通路的干预作用研究
Zahra Haghighatian,Elham Goodarzi,Babak Hadian et al.
Zahra Haghighatian et al.
Introduction: Renal ischemia-reperfusion (RIR) induces inflammation, oxidative stress, and impaired renal function, partly through reduced nitric oxide (NO) availability. Rosuvastatin enhances NO production and has report...