Study on the potential mechanism of Cordyceps militaris in chronic obstructive pulmonary disease via integrating metabolomics and network pharmacology [0.03%]
基于网络药理学和代谢组学探讨冬虫夏草干预慢性阻塞性肺病的潜在机制研究
Ping Wang,Yuqi Zong,Xiao Huang et al.
Ping Wang et al.
Objective: This research aimed to evaluate the beneficial impact of Cordyceps militaris (CM) on chronic obstructive pulmonary disease (COPD) and methodically clarify its underlying processes. ...
Bif-1 induces vascular remodeling in injured rat carotid artery by engaging β-catenin signaling [0.03%]
Bif-1通过诱导β-catenin信号通路参与血管重塑促进损伤颈动脉修复
Jie Wei,Chaorui Wang,Jie Li et al.
Jie Wei et al.
Background: Bax-interacting factor-1 (Bif-1) is well-documented in the regulation of cancers and neurodegenerative disorders. However, its role in vascular diseases remains largely unexplored. Here, we demonstrate a criti...
Molecular mechanisms involved in the immunomodulatory action of Baccharis dracunculifolia DC. extract using an integrated in silico/in vitro approach [0.03%]
一种综合的计算/体外方法研究Baccharis dracunculifolia DC.提取物免疫调节作用的分子机制
Giorgio Cappellucci,Marco Biagi,Mariana Romão-Veiga et al.
Giorgio Cappellucci et al.
Objectives: Ethnobotany and the traditional use of medicinal plants is still a key starting point for the discovery of new drugs in modern medicine, despite often being underrated. Baccharis dracunculifolia DC., the major...
Endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine ameliorates lipopolysaccharide-induced airway inflammation and bronchial hyperreactivity in mice [0.03%]
内源性一氧化氮合酶抑制剂不对称二甲基精氨酸缓解脂多糖致小鼠气道炎症和支气管高反应性
Yasemin Karaman,Yesim Kaya-Yasar,Sevgen Celik Onder et al.
Yasemin Karaman et al.
Objectives: Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase inhibitor. ADMA concentrations are augmented in lung, plasma samples of asthmatics. It remains unclear whether the increased concentrat...
Traditional uses, phytochemistry, and pharmacological effects of Sedum sarmentosum: a review [0.03%]
石吊兰的民间应用、化学成分及药理作用研究进展
Jie Tian,Cheng Fu,Yufeng Li et al.
Jie Tian et al.
Objective: This review comprehensively summarizes the botany, traditional applications, phytochemistry, pharmacological activities, toxicology, and quality control of Sedum sarmentosum, aiming to provide a reference for i...
Effect of honokiol on abemaciclib metabolism both in vitro and in vivo [0.03%]
Honokiol对阿贝西利代谢的影响（体内外研究）
Tian Yang,Wei Song,Zebei Lu et al.
Tian Yang et al.
Objectives: Co-administration of multiple drugs typically induces drug-drug interactions (DDIs). DDIs have the potential to exert significant effects on the pharmacokinetics and therapeutic efficacy of the drugs employed....
Oblongifolin B isolated from Brazilian red propolis exhibits anti-methicillin-resistant Staphylococcus aureus action and modulates macrophage activity [0.03%]
从巴西红色蜂胶中分离出的 Oblongifolin B 对耐甲氧西林金黄色葡萄球菌具有抑制活性并调节巨噬细胞活性
Jônatas Felipe Dos Santos Almeida,Mariana da Silva Honorio,Emilly Camargo Lopes et al.
Jônatas Felipe Dos Santos Almeida et al.
Objectives: Methicillin-resistant Staphylococcus aureus (MRSA) is a Gram-positive bacterium found in hospital-acquired infections, particularly in immunosuppressed individuals. Brazilian red propolis is a beekeeping produ...
Phytochemical analysis, anti-inflammatory property, wound-healing, and anti-granuloma effect of Moroccan aqueous leave extract of Moringa oleifera [0.03%]
摩洛哥辣木叶水提取物的植化分析、抗炎性、促伤口愈合及抗肉芽肿效果
Azraida Hajar,Hamid Kabdy,Baslam Abdelmounaim et al.
Azraida Hajar et al.
Objectives: Inflammation is a vital response to injury or infection but can lead to diseases if chronic. Natural remedies like plant extracts present potential alternatives to synthetic drugs, offering efficacy with fewer...
Characterizing resistance in prostate cancer at a single cell level with hormonal treatment and epigenetic inhibitors [0.03%]
雄激素和表观遗传抑制剂治疗前列腺癌单细胞水平的耐药机制刻画
Morgan Howells,Priyadarsini Gangadharannambiar,Calum McMullen et al.
Morgan Howells et al.
Background: Late-stage prostate cancer is treated with hormonal therapy. While initially effective, development of drug resistance is common. Hypoxia, a local-environmental occurrence in tumours, is known to trigger hormo...
Co-encapsulated resveratrol and paclitaxel in liposomes coating with RGDfC peptide for drug resistance reversal in renal cell carcinoma [0.03%]
RGDfC多肽包被的白藜芦醇和紫杉醇共载脂质体逆转肾细胞癌耐药性
Jianqiang Bian,Liang Yang,Chao Wang et al.
Jianqiang Bian et al.
Background: Drug resistance critically impedes renal cell carcinoma therapy. A dual-targeted liposomal system that codelivered resveratrol (RES) and paclitaxel (PTX) with αvβ3 integrin-targeting was developed to overcom...