High-dose carbidopa achieves sustained levodopa pharmacokinetics and efficacy in Parkinson's disease models [0.03%]
高剂量卡比多巴使帕金森病模型持续获得左旋多巴药代动力学和疗效
Akane Hayashi,Atsushi Hosomi,Shinichi Uchida et al.
Akane Hayashi et al.
Objectives: To evaluate the impact of supraclinical doses of carbidopa on the pharmacokinetics and pharmacodynamics of levodopa in rat and monkey models of Parkinson's disease and to assess the causes for the insufficienc...
Artificial intelligence-enabled nanomedicine: enhancing drug design and predictive modeling in pharmaceutics [0.03%]
人工智能驱动的纳米医药：增强药物设计和药学预测模型
Omnia M Sarhan,Mostafa I Gebril,Doaa Elsegaie
Omnia M Sarhan
The integration of artificial intelligence (AI) and nanomedicine has initiated a revolutionary phase in pharmaceutical research, facilitating progress in targeted drug delivery, controlled release, and personalized therapeutics. This review...
A novel rhein derivative Y01 inhibits hepatocellular carcinoma by inducing apoptosis through regulating PI3K/AKT/mTOR pathway [0.03%]
一种新型化合物Y01通过调节PI3K/AKT/mTOR信号通路诱导肝癌细胞凋亡并抑制肝癌生长
Mingyu Ji,Mulan Li,Zhihong Zhou et al.
Mingyu Ji et al.
Purpose: The aim of this study was to evaluate the novel rhein derivative Y01 for its anti-HCC activity and potential molecular mechanisms, thereby positioning it as a promising candidate for HCC therapy. ...
Selenium and iron oxide nanoparticles mitigate doxorubicin-induced cardiomyopathy in rats via Nox1/p53 pathway inhibition [0.03%]
硒和铁氧化物纳米粒子通过抑制Nox1/p53通路缓解多柔比星诱导的实验性大鼠心肌病
Omnia F Hassan,Marwa H S Dawoud,Sherine M Ibrahim
Omnia F Hassan
Cardiovascular diseases, such as arrhythmia and cardiomyopathy, are leading causes of mortality worldwide. Cardiomyopathy is often triggered by oxidative stress. Objective The current study aims to investigate the therapeutic potential of s...
Correction to: Icariside I reduces breast cancer proliferation, apoptosis, invasion and metastasis probably through inhibiting IL-6/STAT3 signaling pathway [0.03%]
题注：淫羊藿素I通过抑制IL-6/STAT3信号通路减少乳腺癌的增殖、凋亡、侵袭和转移
Published Erratum
The Journal of pharmacy and pharmacology. 2025 Nov 27:rgaf122. DOI:10.1093/jpp/rgaf122 2025
Bibliometric analysis of ferroptosis in atherosclerosis from 2015 to 2024 [0.03%]
2015-2024年铁死亡在动脉粥样硬化领域文献计量分析
Ke-Qian Chen,Wei Li,Shu-Zhi Wang
Ke-Qian Chen
Background: In recent years, ferroptosis has gradually become the focus of research. Although existing studies have demonstrated that inhibition of ferroptosis can improve the progression of atherosclerosis, no researcher...
The role of PEDF in ageing and development: reduction of oxidative damage and support for stem cells [0.03%]
PEDF在衰老和发育中的作用：减少氧化损伤和支持干细胞
Crispin R Dass,Joshua H Dass
Crispin R Dass
This review highlights recent findings on the versatile serpin protein, pigment epithelium-derived factor (PEDF), as pertains to its roles in ageing and development, including its linked functions as an antioxidant and in stem cell support....
Revealing action mechanisms of Xiaoyaosan decoction for the treatment of nonalcoholic fatty liver in mice employing tandem mass tag quantitative proteomics [0.03%]
基于串联质量标签定量蛋白质组学揭示小药膳治疗非酒精性脂肪肝的作用机制
Hong-Xiang Jiang,Ya-Ge Li,Chao Sun et al.
Hong-Xiang Jiang et al.
Objective: To investigate the mechanism and pharmacological activity of (Xiaoyaosan decoction) XYSD in the treatment of NAFL (nonalcoholic fatty liver) by proteomic techniques. ...
N-salicyloyl tryptamine derivative exerts antiatherosclerotic effects by ameliorating endothelial inflammation and apoptosis [0.03%]
N-水杨酰基色胺衍生物通过改善内皮炎症和凋亡发挥抗动脉粥样硬化作用
Liuli Cao,Yang Ding,Lixia Li et al.
Liuli Cao et al.
Objectives: Atherosclerosis (AS) is a chronic inflammatory disease driven by lipids that poses a serious threat to human health. Therefore, the development of drugs with both anti-inflammatory and lipid-lowering propertie...
Phillyrin improves pulmonary epithelial barrier dysfunction in LPS-induced acute lung injury through the RhoA/ROCK signaling pathway [0.03%]
Phillyrin通过RhoA/ROCK信号通路改善内毒素诱导的急性肺损伤大鼠肺上皮屏障功能障碍
Yingzheng Wang,Qianyuan Wu,Limei Li et al.
Yingzheng Wang et al.
Objective: Forsythiae Fructus, the fruit of Forsythia suspensa (Thunb.) Vahl, is a traditional Chinese medicine widely used for clearing heat and detoxifying and for treating inflammatory conditions such as fever and resp...