Sonoran propolis induces a pro-apoptotic effect through mitotic arrest: a distinct cell cycle outcome compared with its main plant source, Populus fremontii [0.03%]
索诺兰蜂胶通过有丝分裂阻滞诱导促凋亡效应：与其主要植物来源杨树（Populus fremontii）相比具有不同的细胞周期结果
Efrain Alday,Patricia Ruiz-Bustos,Adriana Garibay-Escobar et al.
Efrain Alday et al.
Objectives: The aim of this study was to elucidate the molecular events of cell cycle progression underlying alterations in cell morphology, as well as the pro-apoptotic and antiproliferative effects of Sonoran propolis (...
Comparative Study
The Journal of pharmacy and pharmacology. 2026 Jan 16;78(1):rgaf130. DOI:10.1093/jpp/rgaf130 2026
Elucidating the molecular mechanism of Bazhen decoction in the treatment of liver cancer: an integrated approach using network pharmacology, cancer databases, molecular docking, and experimental validation [0.03%]
八珍汤治疗肝癌的分子机制研究：网络药理学、癌症数据库、分子对接和实验验证相结合的方法
Feng Wang,Yi Wang,Qi Wang et al.
Feng Wang et al.
Objectives: To investigate the Bazhen decoction (BZD) mechanism in the treatment of liver cancer (LC). Methods: Integrative approach co...
Antitumor mechanism of traditional Chinese medicine: a review of gut microbiota-mediated immunotherapy [0.03%]
基于肠道微生物的免疫疗法的抗肿瘤机制研究进展（中药视角）
Wen-Jie Wang,Tian-Bo Liu,Ya-Ge Li et al.
Wen-Jie Wang et al.
Objectives: Traditional Chinese Medicine (TCM) has garnered significant interest for its role in modulating gut microbiota to inhibit tumor progression. This review aims to systematically elucidate the mechanistic basis f...
Engineering stimuli-responsive nanocarriers for CRISPR/Cas9 genome editing: next-generation cancer therapeutics [0.03%]
用于CRISPR / Cas9基因编辑的工程刺激响应纳米载体：下一代癌症治疗药物
Sivaraj Mehnath
Sivaraj Mehnath
Objectives: To highlight recent developments in CRISPR/Cas9 genome-editing strategies for cancer therapy and to evaluate how nanocarrier-based delivery systems enable controlled, spatiotemporal manipulation of genetic inf...
Hypoglycemic effect of intranasally delivered insulin improved with coadministrated novel cell-penetrating peptides [0.03%]
新型细胞穿透肽佐剂可改善鼻用胰岛素的降糖效果
Panfeng Yin,Minglu Sun,Si Chen et al.
Panfeng Yin et al.
Objectives: Latroeggtoxin-VI (LETX-VI) was previously shown to cross cell membrane and its C-terminal sequence is the functional peptide segment (FPS) for the transmembrane action. This proof-of-concept study aimed to con...
Pharmacokinetics of pazopanib: a review of the determinants, influencing factors and the clinical importance of therapeutic drug monitoring [0.03%]
帕唑帕尼的药代动力学：治疗药物监测的相关因素、影响因素及其临床意义综述
Nicki M Kyriacou,Annette S Gross,Andrew J McLachlan
Nicki M Kyriacou
Objectives: Pazopanib is an anti-angiogenic small molecule tyrosine kinase inhibitor approved for use in the treatment of advanced renal cell carcinoma and advanced soft tissue sarcoma. This review provides an overview of...
Pharmacokinetic and pharmacodynamic modelling of vedolizumab in Crohn's disease using summary level data and its application to model-informed precision dosing [0.03%]
基于总结数据的维多珠单抗治疗克罗恩病的药代动力学和药效学模型及其在精准给药中的应用
Koji Kimura,Atsushi Yoshida
Koji Kimura
Objectives: To optimize vedolizumab therapy for Crohn's disease, this study aimed to construct a pharmacokinetic/pharmacodynamic (PK/PD) model by applying model-based meta-analysis (MBMA) methods to summary-level clinical...
SIRT-1 activation by quercetin opposes the actions of three transcription factors: p53, ATF4, and NF-κB in a renal ischaemia reperfusion injury in rats [0.03%]
槲皮素通过激活SIRT-1反对三种转录因子：p53，ATF4和NF-κB在大鼠肾缺血再灌注损伤中的作用
Mohamed A Elsherbiny,Abeer Bishr,Miar M Sherif et al.
Mohamed A Elsherbiny et al.
Objective: Renal ischaemia reperfusion (I/R) injury is considered one of the main causes of acute kidney injury which can happen because of kidney transplantation surgeries. Renal I/R injury usually leads to activated inf...
A comparative analysis of machine learning classifiers for chronic liver disease prediction in rats [0.03%]
机器学习分类器在慢性肝病预测中比较分析的研究进展——基于大鼠模型
Aqsa Nadeem,Sonia Bisht,Abhishek Kaushal et al.
Aqsa Nadeem et al.
Objective: The present study investigates machine learning (ML) models to predict the stage of chronic liver disease (CLD) in experimental rats using non-invasive biomarker levels. It aims to establish a reliable ML-based...
The CGA combination enhances bile acids alternative biosynthesis pathway and alleviates MASH induced by methionine-choline-deficient diet [0.03%]
CGA组合增强胆汁酸合成替代通路并缓解蛋氨酸-胆碱缺乏饮食诱导的肝脂肪变性
Jing-Jing Wang,Hai-Lin Yang,Ding-Qi Zhang et al.
Jing-Jing Wang et al.
Objective: CGA combination consisting of Cordyceps sinensis polysaccharide, gypenosides, and amygdalin, is derived from Fuzheng Huayu capsule (a traditional Chinese medicine approved for liver fibrosis) via previous Unifo...