Nanostructured lipid carrier-mediated delivery of donepezil attenuates neuropathic pain via central cholinergic receptor modulation [0.03%]
纳米结构脂质载体介导的多奈哌齐递送通过中枢胆碱能受体调节来减轻神经病理性疼痛
Fernanda Santos Rocha,Rayner Ribeiro Cardoso,João Paulo Prado et al.
Fernanda Santos Rocha et al.
Objectives: This study evaluated the analgesic efficacy of intranasally administered donepezil-loaded nanostructured lipid carriers (DPZ-NLCs) for neuropathic pain (NP), focusing on the involvement of cholinergic receptor...
Qian Yang Yu Yin Granule ameliorates hypertension-induced renal injury through the modulation of oxidative stress via Sestrin2 signaling pathway [0.03%]
千阳育阴颗粒通过调节Sestrin2信号通路抗氧化应激改善高血压肾损伤
Lichao Qian,Shuang Shen,Ying Yang et al.
Lichao Qian et al.
Objective: This study investigated the protective mechanisms of Qian Yang Yu Yin Granule (QYYYG) against hypertensive renal injury. Methods: ...
Anti-inflammatory activity and potential anti-inflammatory mechanisms of Artemisia scoparia essential oil [0.03%]
Artemisia scoparia精油的抗炎活性及可能的作用机制
Panpan Zhang,Xinyu Xu,Haoyu Wang et al.
Panpan Zhang et al.
Objectives: Artemisia scoparia is a perennial herb belonging to the Asteraceae family. Although research has shown that A. scoparia possesses antioxidant and anti-inflammatory properties, the anti-inflammatory activity an...
4-hydroxytamoxifen enhances stemness through the neuropilin-1/estrogen-related receptor alpha pathway to enhance breast cancer cell paclitaxel resistance and metastasis [0.03%]
4-羟基他莫昔芬通过神经纤毛蛋白-1/雌激素受体相关受体α通路增强肿瘤干细胞特性以提升乳腺癌细胞紫杉醇耐药及转移能力
Yanni Lv,Qinglong Yu,Li Zhang et al.
Yanni Lv et al.
Objectives: Tamoxifen is an endocrine therapy for breast cancer that works by competing with estradiol for estrogen receptors, but continued use of tamoxifen by patients can lead to resistance and metastasis. Studies have...
Noncatechin flavonoid-rich extract from Camellia sinensis (L.) Kuntze seed residues ameliorates diabetes and vascular complications in SHRs [0.03%]
茶籽废弃物衍生的非儿茶素黄酮提取物对SHR糖尿病及血管并发症的影响
Kuo-Ping Shen,Shun-Yuan Lin,Chi-Long Hao et al.
Kuo-Ping Shen et al.
Objectives: This study examined the effects of the noncatechin flavonoids (NCFs), a mixture of a range of flavonoids obtained from Camellia sinensis (L.) Kuntze seeds on Type 2 diabetes mellitus (T2DM). ...
Precision pharmaceutics: bioinformatics and pharmacogenomics as catalysts for personalized drug therapy [0.03%]
精准药物学——生物信息学和药物基因组学在个性化治疗中的作用
Jaskaran Preet Singh Saini,Ankita Thakur,Deepak Yadav
Jaskaran Preet Singh Saini
Objectives: This review summarizes how advances in bioinformatics are transforming pharmacogenomics by enabling prediction of individual drug responses and integration of pharmacogenomic data into clinical practice across...
Observed tamoxifen drug interactions are dependent on both CYP2D6 phenotype and inhibitor potency [0.03%]
观察到的他莫昔芬药物相互作用取决于CYP2D6表型和抑制剂 potency大小
Denise N Keller,Samantha J Medwid,Robin M Legan et al.
Denise N Keller et al.
Objectives: Tamoxifen is a prodrug that undergoes cytochrome P450(CYP)-mediated bioactivation to its active metabolite endoxifen, primarily due to CYP2D6. We aimed to investigate the clinical impact of CYP2D6 phenotype on...
Ziziphus jujuba var. spinosa: a systematic review of phytochemistry, pharmacology, and sustainable resource utilization of its multiple plant parts [0.03%]
刺梨枣：化学、药理及资源的综合利用系统综述研究
Xiaohua Zheng,Wei Fu,Xinzhong Lin et al.
Xiaohua Zheng et al.
Objectives: Ziziphus jujuba var. spinosa, commonly known as sour jujube, has been utilized for millennia in traditional Chinese medicine and functional foods. This review comprehensively summarizes the phytochemistry, pha...
K41-A enhances the antiproliferative efficacy of cisplatin in neuroblastoma by modulating apoptosis and autophagy [0.03%]
K41-A通过调节凋亡和自噬增强顺铂在神经母细胞瘤中的抗增殖功效
Gamze Sanlav,Selen Kum Ozsengezer,Zekiye Altun et al.
Gamze Sanlav et al.
Objectives: Neuroblastoma (NB), the most common extracranial tumor in childhood, has a poor prognosis, especially in cases with MYC gene amplification. Cisplatin (CDDP) is widely used in treatment, but its effectiveness i...