Mechanistic insights into mitigation of sepsis-induced acute lung injury by quercitrin via TLR4/MAPK pathway inhibition [0.03%]
黄酮类化合物槲皮素鼠李糖苷通过抑制TLR4MAPK信号通路缓解内毒素致急性肺损伤的机制研究
Qian Sang,Chunhua Cai,Xiaoxiao Lu et al.
Qian Sang et al.
Objectives: Sepsis-induced acute lung injury (ALI) lacks effective treatments. Quercitrin, a natural flavonoid with anti-inflammatory and antioxidant properties, shows therapeutic potential, but its mechanisms, particular...
Geopropolis and anacardic acid: bactericidal and antibiofilm action on multidrug-resistant Staphylococcus epidermidis and modulatory effects on dexamethasone-suppressed macrophages in vitro [0.03%]
地壳质和ана现金酸对多药耐药表皮葡萄球菌的杀菌和抑菌作用及对体外氢化可的松抑制的巨噬细胞的调节效应
Emilly Camargo Lopes,Nicolas Ripari,Jonatas Felipe Santos de Almeida et al.
Emilly Camargo Lopes et al.
Objectives: Staphylococcus epidermidis is a public health concern due to its antimicrobial resistance, causing infections that can worsen in immunosuppressed patients. Geopropolis (GEO) is produced by Meliponines and cont...
Oleanolic acid ameliorates podocyte injury by increasing autophagy to attenuate diabetic nephropathy [0.03%]
熊果酸通过促进自噬改善球壁细胞损伤以缓解糖尿病肾病
Yawei Cheng,Gengliang Li,Yang Li et al.
Yawei Cheng et al.
Objectives: Conventional pharmacotherapies afford only modest renoprotection in diabetic nephropathy (DN). Oleanolic acid (OA), a pentacyclic triterpenoid abundant in Traditional Chinese Medicine (TCM), mitigates DN, but ...
Integrated metabolomics and network pharmacology reveal multi-target phytotherapeutic activities of Frankenia hirsuta against inflammation and diabetic neuropathy with cytotoxic potential [0.03%]
整合代谢组学和网络药理学揭示了弗兰肯尼亚·胡里苏塔针对炎症和糖尿病神经病的多靶点植物治疗活性及细胞毒性潜力
Amaal H Zokalih,Seham El Hawary,Abeer M El Sayed et al.
Amaal H Zokalih et al.
Objectives: Frankenia hirsuta (FH) is an underexplored halophytic plant used for managing inflammatory and metabolic disorders. However, its phytochemical composition and pharmacological mechanisms remain largely uncharac...
Brazilian green propolis exerts anti-inflammatory effects on monocytes from women with early- and late-onset preeclampsia [0.03%]
巴西绿蜂胶对早期和晚期子痫前期女性单核细胞的抗炎作用
Vanessa Rocha Ribeiro-Vasques,Mariana Romao-Veiga,Gabriela de Oliveira Franco et al.
Vanessa Rocha Ribeiro-Vasques et al.
Objectives: Propolis is a bee-derived product traditionally used in folk medicine to treat inflammatory diseases. Preeclampsia (PE) is a pregnancy-specific hypertensive disorder that occurs during pregnancy and presents s...
A systematic review of regulatory approved drugs and pharmacological interventions for erectile dysfunction [0.03%]
阳痿的监管批准药物和药理学干预的系统评价
A T Rajasekhar,Sheikh Shafiq Un-Nabi,Senthilraja Kaliyamoorthy et al.
A T Rajasekhar et al.
Objectives: Erectile dysfunction (ED), or impotence, means having trouble getting or keeping an erection. The National Institutes of Health (NIH) says ED can happen to men at any age, but it's more common as men get older...
Dendrophenol attenuates cardiac hypertrophy through inhibition of ferroptosis via the C-Jun/NCOA4 signaling pathway [0.03%]
松酚通过抑制C-Jun/NCOA4信号通路介导的铁死亡来缓解心室肥大
Yongcheng Zhao,Xueyi Liu,Yiming Li et al.
Yongcheng Zhao et al.
Objectives: Cardiac microvascular dysfunction contributes to the pathogenesis of cardiac hypertrophy (CH) and potentially progresses to cardiac failure. Dendrophenol (Den), a naturally derived compound isolated from Dendr...
Formononetin attenuates corticosterone-induced depressive-like behaviors and neuronal damage via ERα/ERK-CREB-BDNF signaling pathway [0.03%]
佛莫诺内汀通过雌激素受体α/ERK-CREB-BDNF信号通路缓解皮质酮所致的抑郁样行为和神经元损伤
Baoying Wang,Hui Liu,Changjing Zhang et al.
Baoying Wang et al.
Objectives: Formononetin (FMN) is known for its significant neuroprotective effects, this study aims to investigate the antidepressant potential and underlying mechanisms of FMN. ...
Development and in vitro evaluation of solution-based pressurized metered-dose inhaler formulations using green propellants [0.03%]
采用环保推进剂制备溶液型压力定量气雾剂及其体外评价研究
Nirmal Marasini,Roger Rao,Daniel Duke et al.
Nirmal Marasini et al.
Objectives: Pressurized metered-dose inhalers (pMDIs) are currently being transitioned from hydrofluoroalkanes HFA134a (1,1,1,2-tetrafluoroethane), HFA 227, and HFA227ea (1,1,1,2,3,3,3-heptafluoropropane) to low-GWP (glob...
The protective effect of febuxostat in a rotenone mouse model of Parkinson's disease: the interplay between PI3K/Akt/mTOR, GSK-3β, and Nrf2/HO-1 signaling pathways [0.03%]
Febuxostat对Rotenone帕金森病小鼠模型的保护作用：PI3K/Akt/mTOR，GSK-3β和Nrf2/HO-1信号通路之间的相互作用
Kholoud Mohamed Lasheen,Zeinab Mohammad,Nouran Ahmed et al.
Kholoud Mohamed Lasheen et al.
Objectives: In a rotenone-induced Parkinson's disease (PD) mouse model, our study explored the neuroprotective effect of febuxostat, a non-purine selective xanthine oxidase inhibitor approved for gout management. In addit...