A regulatory and scientific framework for analytical quality by design in pharmaceutical analysis [0.03%]
药品分析中解析质量设计的监管和科学框架
Abhishek Chauhan,Raj Kamal,Mohit Kumar et al.
Abhishek Chauhan et al.
The application of Quality-by-Design approaches in the development of analytical methods has changed the way drugs are manufactured, switching from trial-and-error and one-variable-at-a-time methods to a structured, risk-based scientific fr...
The impact of compaction by pellet type, spatial arrangement and drug release on MUPS tablets [0.03%]
颗粒类型、空间分布和药物释放对MUPS片剂压实的影响
Guanhua Wang,Natalia Veronica,Wen Liu et al.
Guanhua Wang et al.
Objectives: This study aims to investigate the effect of compaction pressure, coating polymer, pellet core, and spatial arrangement on drug release behaviour in multiple-unit pellet system (MUPS) tableting. ...
Metabolic reprogramming in head and neck cancer: therapeutic opportunities and challenges [0.03%]
头颈部肿瘤的代谢重塑：机遇与挑战
Enas Bani-Ahmad,Joshua Dass,Crispin R Dass
Enas Bani-Ahmad
Objectives: This review explores the metabolic pathways involved in the survival and apoptosis of head and neck cancer (HNC) cells, with a focus on how altered metabolism supports tumour growth and resistance to therapy. ...
Attenuation of cerebral ischemia-reperfusion injury by exogenous hydrogen sulphide: involvement of the Nrf2/HO-1 pathway in NLRP3 inflammasome inhibition [0.03%]
外源性氢硫化物通过Nrf2/HO-1通路抑制NLRP3炎性小体参与减轻脑缺血再灌注损伤
Wei Hua,Yilei Sun,Mingze Sun et al.
Wei Hua et al.
Objectives: Cerebral ischemia-reperfusion injury (CIRI) presents a major therapeutic challenge in stroke management, where oxidative stress and neuroinflammation synergistically exacerbate neuronal damage. This study exam...
Pharmacological evaluation of Orai-1 inhibitor in 3-nitropropionic acid-induced Huntington disease [0.03%]
药理学评估Orai-1抑制剂在3-硝基丙酸诱导的亨廷顿病中的作用
Veerta Sharma,Shareen Singh,Thakur Gurjeet Singh
Veerta Sharma
Objectives: Huntington's disease (HD) is a neurodegenerative condition characterized by a gradual decline in motor skills, cognitive function, and mental health. The 3-nitropropionic acid (3-NPA) model simulates HD-like p...
Compaction of co-amorphous griseofulvin/amino acid powders at elevated temperatures and their "in-tablet" stability [0.03%]
高温下制备灰黄霉素/氨基酸共无定形粉体及其直接压缩成药片后的稳定性研究
Ioannis Partheniadis,Maria Tsouka,Ioannis Nikolakakis
Ioannis Partheniadis
Objectives: Equimolar griseofulvin (GRI) co-amorphous systems (CAMS) with amino-acids (AAs) were prepared by hot-melt-extrusion and evaluated for compactibility and "in-tablet" stability at ambient (21-23°C), intermediat...
Targeting TGF-β1/SMAD pathway and MMP-9 activity: the protective role of Vitamin D and Catechin in diabetic cardiomyopathy [0.03%]
靶向TGF-β1/SMAD通路和MMP-9活性：维生索D和儿茶素在糖尿病心肌病中的保护作用
Samar R Elnaggar,Eman M Sweed,Asmaa Gaber Abdou et al.
Samar R Elnaggar et al.
Objective: This study aimed to evaluate the cardioprotective effects of Vitamin D (Vit D) and Catechin (Cat) against diabetic cardiomyopathy (DCM) in a rat model, specifically focusing on their ability to attenuate cardia...
Geraniol induces apoptosis in gastric cancer cells by inhibiting the Wnt/β-catenin pathway [0.03%]
香茅醇通过抑制Wnt/β-连环蛋白信号通路诱导胃癌细胞凋亡
Xiao-Lan Yu,Si-Jia Guo,Qi-Rui Cai et al.
Xiao-Lan Yu et al.
Significance: Geraniol (GI), an acyclic monoterpene alcohol, exhibits diverse anti-cancer activities. However, its potential effects against gastric cancer remain poorly understood. ...
Integrating crystal engineering with PEG6000 conjugation to formulate advanced solid dispersions of febuxostat for gout management [0.03%]
将晶型工程与PEG6000偶联相结合，制备用于痛风管理的非布司他高级固态分散体 формулировка:中文标题是：将晶型工程与peg6000偶联相结合，制备用于痛风管理的非布索坦高级固态分散体
Doriana T Ungur,Laura Patras,Mihaela M Pop et al.
Doriana T Ungur et al.
Objectives: Febuxostat (FEB) is a poorly soluble xanthine oxidase inhibitor, which limits its in vitro dissolution performance. This study aimed to enhance the aqueous solubility and dissolution behavior of FEB through cr...
Beta-sitosterol-baicalein-guanosine synergistically alleviates Warburg effect in colorectal cancer via EGFR/ERK pathway [0.03%]
β-谷甾醇-巴戟天碱-鸟苷通过EGFR/ERK途径协同缓解结直肠癌的瓦博格效应
Pingsheng Zhou,Qingci Zeng,Qingling Zhang et al.
Pingsheng Zhou et al.
Objectives: This study investigated whether the active ingredients of Pinellia pedatisecta Schott extract (PE) inhibit colorectal cancer (CRC) by targeting the Warburg effect, a common cancer hallmark, and to elucidate th...