The alkylaminoalkanethiosulfuric acids exhibit in-vitro antileishmanial activity against Leishmania (Viannia) braziliensis: a new perspective for use of these schistosomicidal agents [0.03%]
N-烷基氨基硫代硫酸脂肪酸盐类化合物体外抗利什曼病原虫活性研究：一类新的血吸虫病治疗药物的作用新视角
Gabriane Nascimento Porcino,Luciana Maria Ribeiro Antinarelli,Ana Carolina Ribeiro Gomes Maia et al.
Gabriane Nascimento Porcino et al.
The alkylaminoalkanethiosulfuric acids (AAATs) are amphipathic compounds effective against experimental schistosomiasis, of low toxicity, elevated bioavailability after a single oral dose and prompt tissue absorption. ...
Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats [0.03%]
尿素937的药代动力学、药效学和安全性研究：一种外周限制性脂肪酸酰胺水解酶抑制剂
Valentina Vozella,Faizy Ahmed,Paoula Choobchian et al.
Valentina Vozella et al.
Objectives: URB937, a peripheral fatty acid amide hydrolase (FAAH) inhibitor, exerts profound analgesic effects in animal models. We examined, in rats, (1) the pharmacokinetic profile of oral URB937; (2) the compound's ab...
In-vitro-in-silico investigation of the negative food effect of zolpidem when administered as immediate-release tablets [0.03%]
艾司唑仑片剂体内外联合试验的餐后效应研究
Rafael Leal Monteiro Paraiso,Ayahisa Watanabe,Cord J Andreas et al.
Rafael Leal Monteiro Paraiso et al.
Objectives: The main objective of the present work was to combine in-vitro and in-silico tools to better understand the in-vivo behavior of the immediate release (IR) formulation of zolpidem in the fasted and fed states. ...
Effects of the drug combination memantine and melatonin on impaired memory and brain neuronal deficits in an amyloid-predominant mouse model of Alzheimer's disease [0.03%]
药物美金刚和褪黑素对阿尔茨海默病淀粉样蛋白为主的小鼠模型记忆障碍及脑神经元缺陷的影响
Monika Jürgenson,Tamara Zharkovskaja,Aveli Noortoots et al.
Monika Jürgenson et al.
Objectives: Alzheimer's disease (AD) is a neurodegenerative disorder with no cure. Limited treatment options available today do not offer solutions to slow or stop any of the suspected causes. The current medications used...
Attenuating effect of α-pinene on neurobehavioural deficit, oxidative damage and inflammatory response following focal ischaemic stroke in rat [0.03%]
α-蒎烯对缺血性脑卒大鼠神经行为缺陷、氧化损伤及炎症反应的抑制作用
Mahdieh Khoshnazar,Mohammad Reza Bigdeli,Siavash Parvardeh et al.
Mahdieh Khoshnazar et al.
Objectives: Oxidative stress and inflammation have a critical role in the pathogenesis of ischaemic stroke. Alpha-pinene is a monoterpenoid molecule with anti-inflammatory and antioxidant properties. The nobility of the p...
Development of a high-performance liquid chromatography with tandem mass spectrometry method for identifying common adulterant content in saffron (Crocus sativus L.) [0.03%]
一种用于检测藏红花(Crocus sativus L.)中常见掺假物的高效液相色谱-串联质谱法的发展
Weijun Kong,Huijing An,Ji Zhang et al.
Weijun Kong et al.
Objectives: This study aimed to develop an efficient and reliable method for estimating common adulterants in saffron by detecting their characteristic components to warrant its efficacy and regular use as a highly valuab...
Muscone ameliorates diabetic peripheral neuropathy through activating AKT/mTOR signalling pathway [0.03%]
麝香通过激活AKT/mTOR信号通路改善糖尿病外周神经病变
Jie Dong,Hua Li,Yang Bai et al.
Jie Dong et al.
Objectives: Emerging evidence showed that muscone could improve chronic inflammation after myocardial infarction and protect alcohol-induced osteonecrosis of the femoral head. However, the function of muscone on diabetic ...
Review on antibacterial activity of Himalayan medicinal plants traditionally used to treat pneumonia and tuberculosis [0.03%]
用于治疗肺炎和肺结核的喜马拉雅药用植物抗菌活性的研究综述
Muhammad Adnan,Shandana Ali,Khushboo Sheikh et al.
Muhammad Adnan et al.
Objectives: The main objective of this review was to collect scattered literature on ethnomedicinal plants used to treat pneumonia and tuberculosis in the Himalayan region and their in-vitro validation against bacterial p...
Preparation and preliminary pharmacokinetics study of GNA-loaded zein nanoparticles [0.03%]
载甘草多糖纳米颗粒的制备及初步药动学研究
Weiye Cheng,Beilei Wang,Caiyun Zhang et al.
Weiye Cheng et al.
Objectives: Gambogenic acid (GNA), one of the main active ingredients isolated from Garcinia cambogia, has shown diverse antitumour activities. However, short biological half-life and low oral bioavailability severely lim...
F127 poloxamer effect on cytotoxicity induction of tumour cell cultures treated with doxorubicin [0.03%]
F127泊洛沙姆对多柔比星处理的肿瘤细胞系促癌作用的影响研究
Emiliano Alberto Gentile,Cynthia Cecilia Castronuovo,María Luján Cuestas et al.
Emiliano Alberto Gentile et al.
Introduction: Hepatocellular carcinoma is the most common liver malignancy and the third leading cause of cancer death worldwide. One crucial limitation in the pharmacotherapy for this tumour is its chemotherapy-resistant...