Genetic influence of coffee intake on bladder cancer risk: a two-sample Mendelian randomization analysis [0.03%]
基于孟德尔随机化方法分析的咖啡摄入遗传影响与膀胱癌风险关系研究
Qi Zeng,Yu Cheng,Chenlong Wang et al.
Qi Zeng et al.
Background. Bladder cancer (BLCA) is one of the most common malignancies of the urinary system, presenting significant public health challenges due to its rising incidence and associated healthcare costs. Despite known risk factors such as ...
A non-pharmacological intervention for insomnia: tryptophan-fructooligosaccharides combination improves sleep in mice via anti-inflammation and gut microbiota modulation [0.03%]
一种失眠的非药物干预手段：色氨酸低聚果糖组合通过抗炎和调节肠道菌群改善小鼠睡眠质量
Wing-Yan Wong,Brandon Dow Chan,Pak-Ting Cho et al.
Wing-Yan Wong et al.
Insomnia, a widespread condition affecting approximately 30% of the global population, is characterized by persistent sleep disturbances and leads to significant impairments in physical and psychological health. While current treatments can...
Grape pomace extract, rich in phenolic compounds, attenuates obesity-induced nephropathy by modulating energy metabolism dysregulation and oxidative stress in mice fed a high-fat diet [0.03%]
富含酚类化合物的葡萄皮渣提取物通过调节高脂饮食小鼠的能量代谢失调和氧化应激来缓解肥胖诱导的肾病
Tatiana Figueras,Diahann J Perdicaro,Valeria E Cacciamani et al.
Tatiana Figueras et al.
Obesity constitutes a significant risk factor for chronic kidney disease. High-fat diets (HFD) disrupt glucose and lipid metabolism and promote ectopic lipid deposition, leading to renal lipotoxicity and dysfunction. We recently reported th...
A standardised saffron extract improves subjective and objective sleep quality in healthy older adults with sleep complaints: results from the gut-sleep-brain axis randomised, double-blind, placebo-controlled pilot study [0.03%]
藏红花标准化提取物可改善健康老年人的主观和客观睡眠质量：来自肠-脑-睡眠轴随机、双盲、安慰剂对照试点研究的结果
Leonie Lang,Annabel Ditton,Andi Stanescu et al.
Leonie Lang et al.
Sleep disturbances are associated with an increased risk of neurodegenerative diseases and alterations in gut microbiota composition. Saffron (Crocus sativus) has been shown to improve sleep and modulate the gut microbiome, but its effect o...
Dietary microRNAs in aging: sources, mechanisms, translational potential, and future directions [0.03%]
膳食microRNA与衰老：来源、机制、转化潜力及未来方向
Yongwang Xue,Runting Yin,Liang Yin et al.
Yongwang Xue et al.
In recent years, the intensifying global aging trend has made anti-aging research a critical area of scientific interest, with dietary interventions playing an essential role. Among dietary components, food-derived microRNAs (miRNAs), emerg...
Urate-lowering and renal-protective effects of sugarcane polyphenols in hyperuricemia: mechanisms and key components [0.03%]
甘蔗多酚通过降低血尿酸和保护肾脏防治高尿酸血症的作用机制及关键活性成分研究
Kexin Li,Yu Han,Yumei Wang et al.
Kexin Li et al.
Hyperuricemia (HUA) is a metabolic disorder characterized by abnormally elevated levels of uric acid (UA) in the blood, often accompanied by renal damage. The continuous rise in HUA incidence necessitates the development of safe, efficient ...
Lactiplantibacillus plantarum MPB-65 combined with epicatechin alleviates hyperuricemia by modulating the gut-kidney axis [0.03%]
肠-肾轴调节乳植菌植物乳杆菌MPB-65联合表儿茶素缓解高尿酸血症
Zihao Tian,Jing Zhang,Zhongmei Tan et al.
Zihao Tian et al.
Hyperuricemia (HUA) is a metabolic disorder induced by excessive generation or underexcretion of uric acid (UA), leading to abnormally elevated levels of serum UA beyond the normal range. This study explored the potential effects of Lactipl...
Combination of resveratrol and epirubicin to overcome chemoresistance in lung adenocarcinoma organoids: synergistic effects and translational implications [0.03%]
白藜芦醇和表阿霉素联合应用以克服肺腺癌类器官化疗耐药：协同作用及转化意义
Lin-Jie Liu,Hong Li,Chun-Yuan Chen et al.
Lin-Jie Liu et al.
Lung adenocarcinoma (LAC) is the main histological type of non-small cell lung cancer (NSCLC). Adjuvant therapy is required in LAC management but usually encounters drug resistance. Resveratrol (RES) enhances the anti-NSCLC effects of chemo...
Vitamin D improves diabetic cardiomyopathy by inhibiting pyroptosis through the NOX4/NLRP3 inflammasome pathway [0.03%]
维生素D通过NOX4/NLRP3炎性小体途径抑制细胞焦亡改善糖尿病心肌病
Dongxia Wang,Zhen Sun,Huaxing Zhang et al.
Dongxia Wang et al.
Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes mellitus, for which effective treatment options remain unavailable. Recent studies have demonstrated that vitamin D exerts protective effects against DCM, but ...
Theabrownins from dark tea: formation, gut microbiota-mediated biotransformation, health benefits, and potential in functional food applications [0.03%]
黑茶茶褐素：形成、肠道微生物介导的生物转化、健康效益及其功能食品应用潜力
Chunyan Zhang,Mingxi Li,Liya Li et al.
Chunyan Zhang et al.
Theabrownins (TBs) are the major polyphenol-derived pigments and key bioactive components in dark tea formed through microbial fermentation or enzymatic oxidation. This review provides a comprehensive overview of the formation pathways, str...