Advances in the preparation, characterization and biological activities of food-borne selenium-enriched peptides [0.03%]
食品来源硒富集肽的制备、表征及生物活性研究进展
Ying-Chao Qiu,Zi-Ying Zhao,Meng-Jiao Wang et al.
Ying-Chao Qiu et al.
As a vital trace nutrient for the human body, selenium is essential for many physiological functions. However, the prevalence of selenium insufficiency and associated conditions (such as osteoarthritis and Keshan disease) is increasing as a...
NAFLD-related SNPs are linked to changes in liver fat, as measured by the CAP score, and serum lipids in response to a 3-week sugar-sweetened beverage intervention: a pilot study [0.03%]
与非酒精性脂肪肝有关的SNPs与3周内因摄入含糖饮料而导致的肝脏脂肪（CAP评分衡量）和血脂变化相关：一项概念验证试验
Faustina Therase Jeyaraj,Sai Sravani Vennam,Kendra Nelson et al.
Faustina Therase Jeyaraj et al.
Studies show that increased consumption of sugar-sweetened beverages (SSBs) is linked to non-alcoholic fatty liver disease (NAFLD), a condition characterized by excess fat accumulation in hepatocytes. Genetic factors also influence NAFLD. W...
Epigallocatechin-3-gallate ameliorates LPS-induced ARDS by modulating Akkermansia-associated SCFAs metabolism and inhibiting the JAK2/STAT3 candidate signaling pathway [0.03%]
表没食子儿茶素没食子酸酯通过调节Akk菌相关SCFA代谢和抑制JAK2/STAT3候选信号通路改善LPS诱导的ARDS
Shiming Fan,Guofang Yin,Yan Ren et al.
Shiming Fan et al.
Acute respiratory distress syndrome (ARDS) is a leading cause of acute respiratory failure and mortality, characterized by significant inflammation and damage to the alveolar-capillary membrane, which disrupts gas exchange. Although the tri...
Bisdemethoxycurcumin extends lifespan and healthspan in Caenorhabditis elegans via modulation of EGFR-linked signaling pathways [0.03%]
双脱甲氧基姜黄素通过调节EGFR相关信号通路延长秀丽隐杆线虫的健康寿命和寿命
Ruidie Shi,Yihan Zhang,Chaoxue Li et al.
Ruidie Shi et al.
Bisdemethoxycurcumin (BDMC) is a natural curcuminoid with higher solubility and stability than curcumin, yet its potential role in lifespan and healthspan regulation remains largely unexplored. This study aimed to investigate the effects of...
Polysaccharides from edible fungi mycelium: a review on extraction, characterization, bioactivities, and biosynthetic mechanisms [0.03%]
食药用菌菌丝体多糖研究进展：提取、结构特征、活性及合成机制综述
Lixiang Zheng,Mengge Ma,Zhou Chen et al.
Lixiang Zheng et al.
Polysaccharides derived from the mycelium of edible fungi (MEF) are structurally diverse and biologically active macromolecules, garnering extensive attention in functional foods, pharmaceuticals, and biomaterials. Despite the emerging grow...
Kaempferol alleviates right ventricular hypertrophy in high-altitude pulmonary hypertension rats by modulating the AMPK/ACC/CPT1B axis and the AMPK-mediated LDHA/PDHA1 pathway [0.03%]
kaempferol通过调节ampk/acc/cpt1b轴和ampk介导的ldha/pdha1通路缓解高原肺高血压大鼠右心室肥厚
Qiongqiong Zhao,Shanshan Su,Ju Chen et al.
Qiongqiong Zhao et al.
This study evaluates the protective effects of kaempferol on right ventricular (RV) structure and function in a rat model of high-altitude pulmonary hypertension (HAPH) and explores the underlying mechanisms. Male Sprague-Dawley rats (n = 5...
Beyond A1 milk concerns: dietary-relevant concentrations of β-casomorphin-7 show limited absorption but retain opioid-like activity in an intestinal cell model [0.03%]
比A1牛奶问题更深远：具有饮食相关浓度的β-酪啡肽-7展示出有限吸收但是保留类似阿片活性的肠道细胞模型中
Giorgia Antonelli,Giovanni Piccinini,Mattia Santoni et al.
Giorgia Antonelli et al.
Milk and dairy products are a significant source of bioactive peptides, including β-casomorphin-7 (BCM-7), a heptapeptide released from the enzymatic cleavage of the A1 variant of β-casein. While some studies have suggested that BCM-7 may...
Soybean diacylglycerol oil-based diet impacts lipid levels by altering the gut microbiota in C57BL/6J mice [0.03%]
大豆二酰甘油油通过改变肠道菌群影响C57BL/6J小鼠的血脂水平
Jia Guo,Manting Du,Yonghua Wang
Jia Guo
Gut microbiota-derived metabolites can affect host lipid levels in the blood and liver, and a diacylglycerol (DAG)-rich diet prevents obesity-induced lipid abnormality in animals and humans, while the impact of a DAG-rich diet on host gut e...
Dietary EPA shows superior efficacy over DHA in chronic sleep deprivation-induced cognitive decline by disrupting the crosstalk between intestinal ferroptosis and gut-derived Aβ production [0.03%]
膳食EPA通过破坏肠道铁死亡与Aβ产生之间的串扰，优于DHA逆转慢性睡眠剥夺诱导的认知障碍
Lu Chen,Xue Wang,Yueqi Yang et al.
Lu Chen et al.
Growing evidence demonstrates that sleep deprivation (SD) contributes to cognitive impairment by increasing cerebral Aβ levels. While gut-derived Aβ has recently emerged as a potential contributor to brain Aβ pools, its role in SD-mediat...
Systematic evaluation of permeability-related behavior and physicochemical determinants of structurally diverse phytochemicals using a Caco-2 cell model [0.03%]
基于植物化学多样性化合物的通透性相关行为及理化决定因素的系统评价：使用Caco-2细胞模型
Rixing Cong,Jin-Woo Kim,Jun-Su Park et al.
Rixing Cong et al.
Understanding the intestinal permeability of phytochemicals is essential for elucidating their bioavailability and physiological efficacy. This study systematically investigated 162 structurally diverse phytochemicals across 15 chemical cla...