Integrative epidemiological analysis, plasma metabolomics, and single-cell RNA sequencing reveal the protective effects and mechanisms of dietary flavonoids against abdominal aortic aneurysm [0.03%]
整合流行病学分析、血浆代谢组学和单细胞RNA测序揭示膳食类黄酮对腹主动脉瘤的保护作用及机制
Xiaoya Sun,Jingyi Ren,Zhenao Zhang et al.
Xiaoya Sun et al.
Although flavonoids have been shown to have various health benefits, their association with abdominal aortic aneurysm (AAA) and the underlying mechanisms remain unclear. This study included 188 101 UK Biobank participants who were free of A...
Enhanced metabolic flexibility links Mediterranean diet with cognition: interim findings from a randomized controlled trial [0.03%]
增强的代谢灵活性链接地中海饮食与认知：随机对照试验的中期发现
Meryl Cruz,Miriam Martínez-Huélamo,Elena M Yubero-Serrano et al.
Meryl Cruz et al.
Metabolomics contributes to the understanding of mechanisms by which dietary interventions can minimize the progression of mild cognitive impairment (MCI) to dementia. In this study, changes in metabolomics profiles were analyzed to assess ...
Bioactive polysaccharide from Rosa roxburghii Tratt fruit ameliorates metabolic dysfunction-associated steatotic liver disease via AMPK and autophagy pathways [0.03%]
粗花越桔果生物活性多糖通过AMPK和自噬途径改善与代谢紊乱相关的脂肪变性肝病
Qing Chen,Yue Zhang,Siming Zhu et al.
Qing Chen et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent metabolic disorder with limited therapeutic options. Here, we investigated the protective effects and underlying mechanisms of a polysaccharide extracted from R...
Milk-delivered postbiotics from Bifidobacterium animalis subsp. lactis BB-12 modulate the gut microbiota-SCFA-immune axis in rats compared to probiotic delivery [0.03%]
与益生菌递送相比，乳制品递送的副产物Bifidobacterium animalis subsp. lactis BB-12调节大鼠肠道微生物群-SCFA-免疫轴
Ecem Akan,Esra Orenlili Yaylagul,Adem Yavaş et al.
Ecem Akan et al.
Despite growing interest in postbiotics as stable alternatives to probiotics, their efficacy when delivered through food matrices and their integrated effects on the gut microbiota-metabolite-immune axis remain poorly understood. This study...
Quinoa regulates hepatic lipid metabolism in MASLD mice via PPARγ-PLIN2 [0.03%]
藜麦通过PPARγ-PLIN2调节MASLD小鼠肝脂代谢
Peijie Liu,Jingyang Wan,Luping Qiao et al.
Peijie Liu et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) primarily results from excessive nutrient consumption, with lifestyle modifications, particularly dietary interventions, constituting a principal strategy for its management. ...
Curcumin ameliorates Salmonella-induced enteritis by restraining NF-κB signaling and restoring microbiota-SCFA homeostasis [0.03%]
姜黄素通过限制NF-κB信号传导并恢复微生物群-SCFA稳态来改善沙门氏菌引起的肠炎
Mengru Liu,Yining Feng,Xiaochang Guo et al.
Mengru Liu et al.
Foodborne Salmonella infection triggers excessive inflammation, mucosal injury and gut microbiota dysbiosis. Here, curcumin was evaluated as a dietary bioactive against Salmonella-induced enteritis using in silico target-network analysis, m...
Validation of the Westernized Diet Index (WDI) through inflammatory, oxidative stress, and metabolic biomarkers and its association with overweight/obesity-evidence from a case-control study [0.03%]
通过炎症、氧化应激和代谢生物标志物验证西方饮食指数(WDI)及其与超重/肥胖的关联-来自病例对照研究的证据
Farhad Vahid,Torsten Bohn
Farhad Vahid
The global rise in obesity is linked to Western dietary patterns (WDPs). The Westernized Diet Index (WDI) was developed to measure adherence to WDPs. This study examined the associations between the WDI and overweight/obesity and constructi...
Kinetics of calcium release in the GIT influenced by whey protein structures: an in vitro digestion study using a dynamic model [0.03%]
动态模型下乳清蛋白结构对消化道钙释放动力学的影响：体外消化研究
Xinya Wang,Aiqian Ye,Harjinder Singh et al.
Xinya Wang et al.
Calcium (Ca), primarily consumed through diet, is essential for skeletal health and various other biological functions in humans. While the mechanisms of Ca absorption are well understood, little is known about the role of food structure pr...
A Peptidase A1 domain protein from Stropharia rugosoannulata: ACE inhibition and multi-pathway vascular modulation [0.03%]
褶环柄菇中的一种肽基酶A1结构域蛋白：血管紧张素转换酶抑制及多通路的血管调节作用
Wen Li,Wanchao Chen,Zhong Zhang et al.
Wen Li et al.
A Peptidase A1 domain-containing protein (SRP, 43.1 kDa, >95% purity) was isolated from the edible mushroom Stropharia rugosoannulata and characterized for its structural properties, and ACE inhibitory and vascular modulatory activities. Th...
Disruption of mucosal immune homeostasis in food allergy: a convergence of genetic, barrier, microbiome, and environmental triggers [0.03%]
食物过敏中黏膜免疫稳态的破坏：遗传、屏障、微生物群和环境触发因素的汇聚
Xing Zhang,Da Gan,Yuyang Shi et al.
Xing Zhang et al.
Food allergy is a pathological immune response to food antigens. Its global prevalence continues to rise, making it a significant public health and food safety concern. This review describes the pathogenesis of food allergy, proposing that ...