Integrated transcriptomics and untargeted metabolomics reveal bone development and metabolism of newly weaned mice in response to dietary calcium and boron levels [0.03%]
整合转录组学和非靶向代谢组学揭示了饮食中钙和硼水平对新生鼠骨发育及新陈代谢的响应机制
Shuo Li,Xuehai Cao,Tiande Zou et al.
Shuo Li et al.
Epidemiological and animal studies have indicated that calcium and boron are essential for bone development and metabolism. However, limited information is available regarding the effects of boron supplementation on bone development and met...
High-fat diet promotes type 2 diabetes mellitus by disrupting gut microbial rhythms and short-chain fatty acid synthesis [0.03%]
高脂饮食通过扰乱肠道微生物节律和短链脂肪酸合成促进2型糖尿病发生发展
Yangrui Wang,Fenfen Yan,Qingxue Chen et al.
Yangrui Wang et al.
Diabetes ranks among the top 10 causes of death globally, with over 90% of individuals diagnosed with diabetes having type 2 diabetes mellitus (T2DM). It is acknowledged that a high-fat diet (HFD) poses a serious risk for T2DM. The imbalanc...
Relationships of dietary habits with prostate cancer risk: results from Mendelian randomization analyses and the National Health and Nutrition Examination Survey [0.03%]
饮食习惯与前列腺癌风险关系的孟德尔随机化分析及美国国家健康和营养调查结果
Zhen Zhou,Jin Xu,Yang Zhao et al.
Zhen Zhou et al.
Background: Prior investigations identified correlations between dietary habits and the risk of prostate cancer (PCa); however, the causative dynamics are unclear. Methods: Utilizing the Mendelian randomization (MR) framework, we investigat...
Human breast milk-derived phospholipid DOPE ameliorates intestinal injury associated with NEC by inhibiting ferroptosis [0.03%]
人乳磷脂DOPE通过抑制铁死亡改善与NEC相关的肠损伤
Yanjie Chen,Wenjuan Chen,Yu Dai et al.
Yanjie Chen et al.
Neonatal necrotizing enterocolitis (NEC) is a severe inflammatory bowel disease that commonly affects premature infants. Breastfeeding has been proven to be one of the most effective methods for preventing NEC. However, the specific role of...
Antigenotoxic and cosmetic potential of elderberry (Sambucus nigra) extract: protection against oxidative DNA damage [0.03%]
刺梨提取物的抗致突变和化妆品潜力：对抗氧化性DNA损伤
Sara Gonçalves,Francisco Peixoto,Tayse F F da Silveria et al.
Sara Gonçalves et al.
The integrity of the genome is under constant threat from both endogenous and exogenous factors that induce oxidative stress and accelerate ageing. The demand for natural and organic cosmetics is rising due to the harmful effects of synthet...
Lactobacillus plantarum 69-2 combined with α-lactalbumin hydrolysate alleviates DSS-induced ulcerative colitis through the TLR4/NF-κB inflammatory pathway and the gut microbiota in mice [0.03%]
枯草芽孢杆菌LP6结合α-乳白蛋白水解物通过TLR4/NF-κB炎症通路和肠道菌群缓解小鼠DSS诱导的溃疡性结肠炎
Yue Ma,Chuanbing Hu,Jing Zhang et al.
Yue Ma et al.
Ulcerative colitis (UC), an inflammatory bowel disease, seriously affects people's quality of life. Diet-derived active peptides and Lactobacillus plantarum have shown promise for mitigating symptoms of UC. This investigation explored the c...
Biological effects and mechanisms of dietary chalcones: latest research progress, future research strategies, and challenges [0.03%]
饮食查尔酮的生物学效应及其机制：最新研究进展、未来研究策略与挑战
Yun Liang Zhang,Shuang Jiao Sun,Li Zeng
Yun Liang Zhang
Dietary plants are an indispensable part of the human diet, and the various natural active compounds they contain, especially polyphenols, polysaccharides, and amino acids, have always been a hot topic of research among nutritionists. As pr...
Acute supplementation with a curcuminoid-based formulation fails to enhance resting or exercise-induced NRF2 activity in males and females [0.03%]
口服类姜黄素补充剂对男女受试者静息和运动诱导的NRF2活性的影响甚微
Josh Thorley,Abrar Alhebshi,Ana Rodriguez-Mateos et al.
Josh Thorley et al.
Purpose: Exercise and (poly)phenols may activate nuclear factor erythroid 2-related factor 2 (NRF2), a transcription factor that coordinates antioxidant synthesis. The purpose of this study was to determine whether curcuminoid supplementati...
Randomized Controlled Trial
Food & function. 2024 Oct 28;15(21):10782-10794. DOI:10.1039/d4fo02681k 2024
Oral delivery of electrohydrodynamically encapsulated Lactiplantibacillus plantarum CRD7 modulates gut health, antioxidant activity, and cytokines-related inflammation and immunity in mice [0.03%]
静电水动力学包埋的植物乳杆菌CRD7口服液对小鼠肠道健康、抗氧化活性及细胞因子相关炎症和免疫的影响
Vinay Venkatesh Varada,Sachin Kumar,Sravani Balaga et al.
Vinay Venkatesh Varada et al.
The current study aimed to evaluate the effects of L. plantarum CRD7 on performance and gut health biomarkers in a Swiss albino mouse model. The results showed that supplementation with non-encapsulated (NLP) and electrohydrodyanamically en...
Unravelling the potential of yolkin for nutraceutical use: the origin, structure, and functional insights of a hen egg yolk polypeptide complex [0.03%]
解密卵黄素的潜在功效：一种蛋黄多肽复合物的来源、结构及功能解析
Aleksandra Zambrowicz,Katarzyna Kapczyńska,Paweł Kania et al.
Aleksandra Zambrowicz et al.
Nutraceuticals can reduce the risk of many diseases, such as cardiovascular disease, immune deficiencies, neurodegeneration, and others. Their delivery remains a challenge because it depends on many factors, most notably the stability of th...