Quercetin prevents the USP22-Snail1 signaling pathway to ameliorate diabetic tubulointerstitial fibrosis [0.03%]
染料木素通过抑制USP22去泛素化Snail1的信号途径改善糖尿病肾间质纤维化
Xilin Zhao,Songping Wang,Xuelan He et al.
Xilin Zhao et al.
Our previous studies have demonstrated that ubiquitin-specific peptidase 22 (USP22) has the capacity to accelerate renal epithelial-to-mesenchymal transition (EMT) and promote the pathological progression of diabetic tubulointerstitial fibr...
Brassica rapa L. crude polysaccharide meditated synbiotic fermented whey beverage ameliorates hypobaric hypoxia induced intestinal damage [0.03%]
粗多糖介导的布拉氏酵母菌-乳清发酵饮品对低氧所致肠损伤的改善作用研究
Yuanlin Niu,Tingting Zhao,Zhenjiang Liu et al.
Yuanlin Niu et al.
Hypobaric hypoxia causes oxidative stress and inflammatory responses and disrupts the gut microbiome and metabolome. In this study, we developed a synbiotic fermented whey beverage, combining kefir and Brassica rapa L. crude polysaccharides...
A network meta-analysis of the comparative efficacy of different dietary approaches on glycaemic control and weight loss in patients with type 2 diabetes mellitus and overweight or obesity [0.03%]
不同饮食方案对2型糖尿病合并超重或肥胖患者血糖控制和体重减轻疗效的网状Meta分析
Yahui Yuan,Chun Chen,Qiaoyun Liu et al.
Yahui Yuan et al.
Background: Despite considerable literature supporting the benefit of dietary interventions in individuals with type 2 diabetes mellitus (T2DM) and overweight/obesity, which diet works best is currently unknown. We conducted a systematic re...
Meta-Analysis
Food & function. 2024 Dec 9;15(24):11961-11974. DOI:10.1039/d4fo00337c 2024
Bioaccessibility and unravelling of polyphenols, sulforaphane, and indoles biotransformation after in vitro gastrointestinal digestion of a novel lactofermented broccoli beverage [0.03%]
新型乳酸发酵西兰花饮料体外胃肠消化后多酚、硫化物和吲哚的生物可及性和生物转化规律
José Ángel Salas-Millán,Encarna Aguayo
José Ángel Salas-Millán
This study assesses the transformation and stability of polyphenols, sulforaphane, and indoles in a fermented beverage made from broccoli leaves during in vitro gastrointestinal digestion (GID). This process was simulated using a dialysis m...
Cocoa flavanols rescue stress-induced declines in endothelial function after a high-fat meal, but do not affect cerebral oxygenation during stress in young, healthy adults [0.03%]
cocoa类黄烷醇可缓解压力导致的高脂饮食引起的内皮功能下降，但不影响健康年轻人在压力情况下的脑部氧合作用
Rosalind Baynham,Jet J C S Veldhuijzen van Zanten,Catarina Rendeiro
Rosalind Baynham
Food choices during stressful periods often worsen, which can influence the impact of stress on vascular health. For instance, fat consumption impairs the recovery of endothelial function following mental stress, while flavanols have been s...
Randomized Controlled Trial
Food & function. 2024 Nov 25;15(23):11472-11490. DOI:10.1039/d4fo03834g 2024
Synergistic effects of Ligilactobacillus salivarius Li01 and psyllium husk prevent mice from developing loperamide-induced constipation [0.03%]
鼠李糖乳杆菌Li01和西梅果皮纤维协同作用可预防洛哌丁胺致小鼠便秘
Lvwan Xu,Bo Qiu,Furong Ba et al.
Lvwan Xu et al.
Constipation is a gastrointestinal (GI) condition marked by difficulty in defecation, abdominal pain and distension, significantly impacting both physical and mental health. Ligilactobacillus salivarius Li01 (Li01) is a probiotic known to p...
Identification and taste characteristics of novel umami peptides from Yanjin black bone chicken hydrolysates and their binding mechanism with umami receptor [0.03%]
阎晋乌鸡多肽型呈味物质的鉴定及其鲜味受体结合机制研究
Yuanyuan Ai,Yun Niu,Yingrun Fan et al.
Yuanyuan Ai et al.
This study aimed to obtain umami peptides from Yanjin black bone chicken and to investigate the formation mechanism of umami taste. The umami peptides were purified from the enzymatic hydrolysate of chicken using ultrafiltration (UF), gel f...
Integrated microbiome and metabolomic analyses revealed the antifibrotic effect of vanillic acid on thioacetamide-induced liver fibrosis in mice [0.03%]
整合微生物组和代谢组分析揭示了香草酸对噻唑烷酮诱导的小鼠肝纤维化的抗纤维化作用
Xiaofeng Cen,Wei Wang,Siyan Hong et al.
Xiaofeng Cen et al.
Vanillic acid (VA) is a natural phenolic acid compound that is widely found in various foods and medicinal plants, with a remarkable antifibrotic effect observed in animal studies, but its exact antifibrotic mechanism remains unclear. Herei...
Dietary Lactobacillus johnsonii-derived extracellular vesicles ameliorate acute colitis by regulating gut microbiota and maintaining intestinal barrier homeostasis [0.03%]
乳酸菌Johnsonii衍生的细胞外囊泡通过调节肠道微生物群和维持肠屏障稳态来改善急性结肠炎
Zhiguo Li,Mengyu Li,Xuexun Fang et al.
Zhiguo Li et al.
Inflammatory bowel disease (IBD) is a chronic gastrointestinal disease with intricate pathogenesis, and clinical treatment is still not ideal. The imbalance of gut microbiota is associated with IBD progression. Various probiotics have been ...
Rosmarinic acid alleviated intestinal barrier damage caused by Escherichia coli by regulating the gut microbiota and inhibiting the NF-κB signalling pathway in mice [0.03%]
岩梗酸通过调节肠道菌群和抑制NF-κB信号通路缓解大肠埃希氏菌引起的肠屏障损伤
Dandan Yi,Xia Liu,Menghui Wang et al.
Dandan Yi et al.
Escherichia coli (E. coli) is a common zoonotic foodborne pathogen that poses a major threat to public health and economic development. Rosmarinic acid (RA) can inhibit intestinal inflammation; however, the protective effect of RA against t...