2'-Fucosyllactose evokes colonization of Alloprevotella and alleviates renal injury in hyperuricemia mice [0.03%]
2'-岩藻糖基乳糖诱发高尿酸血症小鼠Alloprevotella菌定植并缓解肾脏损伤
Yifan Lei,Shuyan Sun,Liping Chen et al.
Yifan Lei et al.
Hyperuricemia (HUA) is a metabolic disease characterized by the overproduction of uric acid (UA) in the blood, with an increasing prevalence of associated renal injury. Intestinal microbiota and its associated metabolites are important medi...
Phenethyl isothiocyanate modulates macrophage migration inhibitory factor and suppresses malignant phenotypes of glioblastoma cells [0.03%]
异硫氰酸苯乙酯调节巨噬细胞迁移抑制因子并抑制胶质母细胞瘤恶性表型
Jeng-Rong Lin,Wen-Chieh Liao,Yin-Hung Chu et al.
Jeng-Rong Lin et al.
Phenethyl Isothiocyanate (PEITC) is a well-studied compound within the isothiocyanate family. Accumulating evidence indicates that PEITC induces apoptosis and inhibits the growth of various cancer cells in vitro, including aggressive gliobl...
D-Tagatose attenuates DSS-induced ulcerative colitis by inhibiting inflammation, reducing intestinal barrier damage and modulating the intestinal flora composition [0.03%]
D-塔果糖通过抑制炎症、减少肠屏障损伤和调节肠道菌群组成来缓解DSS诱导的溃疡性结肠炎
Le Wang,Houzhen Lu,Haitao Gui et al.
Le Wang et al.
Ulcerative colitis (UC) is a prevalent inflammatory bowel disease (IBD) posing a significant health threat. This study explored the protective effects of D-tagatose against DSS-induced colitis in mice and its underlying mechanisms using H&E...
Hyperoside promotes autophagy of colonic epithelial cells to protect intestinal barrier function in ulcerative colitis [0.03%]
hyperoside通过促进溃疡性结肠炎结肠上皮细胞自噬来保护肠道屏障功能
Wenxin Xia,Haochang Lin,Jing Zhang et al.
Wenxin Xia et al.
Intestinal barrier defects represent a significant contributor to the development and progression of ulcerative colitis (UC). This study examined the protective effect of hyperoside (Hyp), a naturally occurring flavonol glycoside with anti-...
Untargeted metabolomics reveals the inhibition effect of a high-fat diet on colorectal cancer tumorigenesis in obesity-resistant mice via regulating bile acid, glutathione, and glycerophospholipid metabolisms [0.03%]
未靶向代谢组学揭示高脂饮食通过调节胆汁酸、谷胱甘肽和甘油磷脂代谢抑制肥胖抵抗小鼠结直肠癌的发生发展
Qi Cheng,Kun Na,Chunsheng Xu et al.
Qi Cheng et al.
The interplay between high fat intake and cancer is complex and multifaceted. Contradictory results exist between obesity, high-fat diet (HFD), and colorectal cancer (CRC), necessitating further research. In this study, we investigated the ...
Effect comparison of inulin with different molecular weights ameliorating intracerebral neuroinflammation induced by advanced glycation end products (AGEs) in diabetic mice [0.03%]
不同分子量的低聚果糖改善糖尿病小鼠晚期糖基化终末产物所致脑内神经炎症的效应比较研究
Yanqi Li,Aizhen Zong,Cuiju Xu et al.
Yanqi Li et al.
Inulin is widely recognized for reducing glucose levels in diabetes mellitus, but its role in concurrent diabetic encephalopathy has rarely been reported. In this study, type 2 diabetic KK-Ay mice were administered inulin with different mol...
Dietary strategies for appetite regulation: satiety and obesity management [0.03%]
膳食调节摄食行为的策略-饱腹感与肥胖管理
Pengkui Xia,Bin Li,Yudie Yu et al.
Pengkui Xia et al.
Increased prevalence of diseases associated with obesity has driven research into appetite suppression to reduce high-calorie intake. Dietary modulation of appetite is recognized as one of the most significant and effective ways to reduce t...
Enzymatic synthesis of β-galactosylated xylitol derivatives modulates gut microbiota and improves obesity-related metabolic parameters in mice [0.03%]
β-半乳糖化木糖醇衍生物的酶法合成可调节小鼠肠道微生物群并改善与肥胖相关的代谢参数
Carlos Sabater,Martina Buonaccorsi,Paloma Delgado-Fernández et al.
Carlos Sabater et al.
Obesity and its associated metabolic disorders are major global health concerns, highlighting the need for novel dietary interventions. Xylitol, a polyol widely used as a sugar substitute, has shown metabolic benefits beyond its sweetening ...
Bioaccessibility and antioxidant capacity of epigallocatechin gallate interacting with mung bean protein: impact of protein structure [0.03%]
表绿豆蛋白结构变化的儿茶素与绿豆蛋白相互作用对其生物可利用度及抗氧化能力的影响
Zhilian Huang,Tingting Li,Jing Wang et al.
Zhilian Huang et al.
The integration of plant proteins with bioactive compounds offers a promising strategy to enhance their environmental stability. This study investigated the complexation of mung bean protein (MBP) with epigallocatechin gallate (EGCG) and th...
Human milk oligosaccharide 2'-fucosyllactose alleviates cognitive impairment via the vagal afferent pathway in Alzheimer's disease mice [0.03%]
人乳低聚糖2'-岩藻糖基乳糖通过迷走神经传入通路缓解阿尔茨海默病小鼠的认知障碍
Mengzhen Jia,Xiaorui Wang,Fangjie Ning et al.
Mengzhen Jia et al.
Alzheimer's disease (AD) is mainly manifested by cognitive dysfunction, accompanied by excessive β-amyloid (Aβ) deposition and neuroinflammation. The regulation of vagus nerve (VN) signal transmission is crucial for influencing the pathol...