Healthcare cost comparison between first-line ibrutinib and acalabrutinib in chronic lymphocytic leukemia patients in the Veterans Affairs [0.03%]
美国退伍军人事务部门慢性淋巴细胞白血病患者一线使用伊布替尼与阿卡替尼的治疗费用比较研究
Lindsey Fitzgerald,Sabyasachi Ghosh,Alex Bokun et al.
Lindsey Fitzgerald et al.
Aim: Bruton's tyrosine kinase inhibitors (BTKis), including ibrutinib and acalabrutinib, transformed the treatment landscape of chronic lymphocytic leukemia (CLL) and small lymphocytic lymphoma (SLL) by improving outcomes compared with chem...
Blood neurofilament light chain as a predictive biomarker for functional outcome of acute ischemic stroke: a systematic review and meta-analysis [0.03%]
血清神经丝轻链蛋白预测急性缺血性卒中功能结局的系统评价和meta分析
Hongyu Xu,Hongyu Lin,Rongxing Qin et al.
Hongyu Xu et al.
Aim: Ischemic stroke continues to be a significant contributor to mortality and disability on a global scale. The blood neurofilament light chain (bNfL) as a prognostic indicator for stroke functional outcomes is a topic of ongoing debate. ...
Estimating per-protocol effects in external comparator analyses using real-world data [0.03%]
基于真实世界数据外部对照分析中按方案效果的估计方法研究
Alind Gupta,Evie Merinopoulou,Stephen J Duffield et al.
Alind Gupta et al.
Analysis of single arm trials complemented with external comparator arms (ECAs) may be used to support evidence of effectiveness of novel therapies in oncology research when a randomized trial is unavailable or unfeasible. However, the inte...
Healthcare costs and treatment patterns associated with glucagon-like peptide 1 receptor agonist use among patients with metabolic dysfunction-associated steatohepatitis [0.03%]
与糖尿病伴发的代谢功能紊乱相关肝炎患者使用胰高血糖素样肽-1受体激动剂相关的医疗费用和治疗模式
Elliot B Tapper,Taylor Ryan,Ni Zeng et al.
Elliot B Tapper et al.
Aim: While only recently approved for the treatment of metabolic dysfunction-associated steatohepatitis (MASH), many patients with MASH have taken glucagon-like peptide-1 receptor agonists (GLP-1 RAs) for the treatment of comorbid Type 2 di...
R WE ready for reimbursement? A round-up of developments in real-world evidence relating to health technology assessment: part 21 [0.03%]
一石二鸟：真实世界证据在支付与准入中的作用
Paul Arora,Sreeram V Ramagopalan
Paul Arora
In this update, we explore the vocal adoption of the target trial emulation framework by the US FDA, the FRAME methodology for systematically evaluating the use and impact of RWE in health technology assessment and regulatory submissions, a...
Cost-effectiveness analysis of endoscopic sinus surgery versus external approach for sinonasal inverted papilloma [0.03%]
内镜鼻窦手术与开放性鼻窦手术治疗鼻窦乳头状瘤的成本效益分析
Juan David Gutiérrez-Posso,Aitor Zabala-López-de-Maturana,Ana Maria Arango-Molina et al.
Juan David Gutiérrez-Posso et al.
Aim: Sinonasal inverted papilloma is a benign yet locally aggressive tumor with potential for recurrence. Surgical resection is the primary treatment, and both endoscopic sinus surgery (ESS) and external approaches are employed depending on...
Comparative safety and effectiveness of direct oral anticoagulants and warfarin in patients with venous thromboembolism in Finland, Norway and Sweden [0.03%]
直接口服抗凝药和华法林在芬、挪、瑞典静脉血栓患者中的安全性和有效性比较研究
Waleed Ghanima,Hanna Pohjantähti,Dimitra Lambrelli et al.
Waleed Ghanima et al.
Aim: Clinical trial data have demonstrated that direct oral anticoagulants (DOACs) are both noninferior to and safer than conventional therapy for the treatment of venous thromboembolism (VTE). This study aimed to compare the effectiveness ...
The cost-effectiveness of real-time continuous glucose monitoring versus intermittently scanned continuous glucose monitoring in individuals with insulin-treated Type 2 diabetes mellitus in Canada [0.03%]
加拿大胰岛素治疗的2型糖尿病患者实时连续血糖监测与间隔扫描持续葡萄糖监测的成本效益比较
Michael Willis,Andreas Nilsson,Hamza Alshannaq et al.
Michael Willis et al.
Aim: Continuous glucose monitoring (CGM) supports glycemic control and reduces diabetes complications. CGM systems include intermittently scanned CGM (is-CGM) and real-time CGM (rt-CGM). While rt-CGM may provide better outcomes than is-CGM,...
Assessing healthcare resource utilization burden and unmet treatment needs in patients with Parkinson's disease: results from a real-world study [0.03%]
帕金森病患者的医疗资源利用负担和未被满足的治疗需求：一项真实世界研究的结果
Malgorzata Ciepielewska,Eddie Jones,Alexander Gillespie et al.
Malgorzata Ciepielewska et al.
Aim: Current Parkinson's disease (PD) research evaluates patients with early and severe PD, but often overlooks patients with intermediate PD. This study aims to quantify unmet treatment needs, disease burden and healthcare resource utiliza...
Optimizing clinical scientific research: the cohort intervention random sampling study with historical controls [0.03%]
优化临床科学研究：基于历史对照的队列干预随机抽样试验
Nadine D de Klerk,Phebe Bq Berben,Myrthe van der Ven et al.
Nadine D de Klerk et al.
Randomized controlled trials (RCTs) are regarded as the highest level of evidence in medical research, but RCTs also have their drawbacks. Over the years, several alternative study designs have been introduced to address these problems. How...