Evaluation of steroid toxicity using the Glucocorticoid Toxicity Index-Metabolic Domains instrument in adults with myasthenia gravis: a real-world study in the USA [0.03%]
美国成人重症肌无力人群糖皮质激素毒性评价：一项真实世界研究（Glucocorticoid Toxicity Index-Metabolic Domains 量表）
Glenn Phillips,Cynthia Qi,Deborah Gelinas et al.
Glenn Phillips et al.
Aim: The Glucocorticoid Toxicity Index-Metabolic Domains (GTI-MD) has been utilized to assess steroid toxicity in clinical trials and practice but has not been applied previously to large datasets. The GTI-MD was used to investigate steroid...
Development and validation of a method to compare outcomes between switchers and continuers in routine clinical practice [0.03%]
开发并验证一种在常规临床实践中比较转换者与继续者的结局的方法及其验证研究
Chuan Gao,Jenny Jiang,Nipun Atreja et al.
Chuan Gao et al.
Aim: In clinical practice, patients may initiate and continue with a treatment (continuers) or switch to another treatment (switchers). Comparison of clinical outcomes between these cohorts can be challenging owing to several factors includ...
Transportability of the comparative effect of finerenone for the treatment of symptomatic chronic heart failure with left ventricular ejection fraction of ≥40%: insights from the FINEARTS-HF trial [0.03%]
来自FINEARTS-HF试验的见解：芬瑞诺酮治疗左心室射血分数≥40%的症状性慢性心力衰竭患者的比较效应的可运输性
Alex J Turner,Claire Leboucher,Cécile Remuzat et al.
Alex J Turner et al.
Aim: Global randomized controlled trials (RCTs) are used to inform reimbursement decisions in multiple markets, meaning the transportability of findings from these RCTs to multiple country-specific populations is critical for evidence-based...
R WE ready for reimbursement? A round-up of developments in real-world evidence relating to health technology assessment: part 26 [0.03%]
万事俱备，只欠证据：第二十六部分——真实世界数据和证据在卫生技术评估中的应用与发展概述
Paul Arora,Sreeram V Ramagopalan
Paul Arora
In this update, we review a framework for identifying and mitigating information bias in electronic health records and administrative claims data, highlighting practical recommendations for study design, variable definition, and statistical...
Comparative safety of direct oral anticoagulants and low-molecular-weight heparin in patients with venous thromboembolism and cancer in Europe [0.03%]
在欧洲静脉血栓栓塞症合并癌症患者中直接口服抗凝剂与低分子量肝素的比较安全性研究
Ellen Brodin,Annie Young,Florian Langer et al.
Ellen Brodin et al.
Aim: This study aimed to compare the safety and effectiveness of direct oral anticoagulants (DOACs) with low-molecular-weight heparin (LMWH) in patients with venous thromboembolism (VTE) and active cancer in a real-world setting in Sweden, ...
Observational Study
Journal of comparative effectiveness research. 2026 May;15(5):e250072. DOI:10.57264/cer-2025-0072 2026
Switching adult patients with spasticity from onabotulinumtoxinA to abobotulinumtoxinA: a real-world data analysis across three US-based treatment centers [0.03%]
从.onabi转变到.a治疗成人痉挛患者的现实世界数据分析：美国三大治疗中心的研究
Nate Way,Edward Dabrowski,Mitchell Paulin et al.
Nate Way et al.
Aim: To assess patient characteristics, treatment patterns, botulinum toxin type-A (BoNT-A) costs and describe safety in adults with spasticity who switched from onabotulinumtoxinA to abobotulinumtoxinA. Materials & methods: Chart data from...
Efficacy of selpercatinib as a first-line treatment for RET-fusion positive non-small-cell lung cancer: a novel two-stage Bayesian network meta-analysis [0.03%]
塞尔帕替尼一线治疗RET融合阳性非小细胞肺癌的疗效：新型两阶段贝叶斯网络meta分析
Jessica E Forsyth,Manoj Khanal,Urpo Kiiskinen et al.
Jessica E Forsyth et al.
Aim: Single-arm trial data is frequently used during the reimbursement of new oncology interventions. Evaluating treatment effects relative to multiple relevant comparators via network meta-analysis (NMA) using data from single-arm trials; ...
Health economic analysis of pulsed field ablation compared to conventional thermal ablation for patients with paroxysmal atrial fibrillation in China [0.03%]
中国导管消融治疗阵发性房颤的卫生经济学分析
Jian Ye,Youqi Fan,Ye Wang et al.
Jian Ye et al.
Aim: To evaluate the cost-utility of pulsed field ablation (PFA) compared with radiofrequency ablation (RFA) and cryoablation, respectively, in Chinese patients with paroxysmal atrial fibrillation. Materials & methods: Patients with paroxys...
Maximizing the impact of real-world evidence on cancer treatment: what do we need to achieve it? [0.03%]
最大化真实世界证据对癌症治疗的影响：我们如何才能实现？
Begoña Bermejo,Rodrigo Dienstmann,Meritxell Bellet et al.
Begoña Bermejo et al.
There is an increasing number of studies using real-world data to examine outcomes of drugs in clinical practice. Therefore, it is crucial to carefully evaluate their quality and findings, extract valuable insights, acknowledge their limita...
Antiretroviral therapy persistence among treatment-experienced people with HIV and mental health disorders and/or substance use disorders in the USA (2017-2024): a retrospective cohort study [0.03%]
在美国(2017年至2024年)，具有精神疾病和/或物质使用障碍的HIV经治患者中抗逆转录病毒治疗依从性的回顾性队列研究
Uche Mordi,Mary J Christoph,Benjamin Chastek et al.
Uche Mordi et al.
Aim: There are limited studies of antiretroviral therapy persistence among people with HIV (PWH) who have a mental health disorder and/or substance use disorder (MHD/SUD). This real-world study analyzed persistence among treatment-experienc...