Sepiapterin as a treatment for people living with phenylketonuria: a plain language summary of the APHENITY trial [0.03%]
四氢生物蝶呤治疗高苯丙氨酸血症患者的疗效：APHENITY试验的简易解读
Ania C Muntau,Sarah Gallagher,Melissa Lah et al.
Ania C Muntau et al.
What is this summary about?: This plain language summary is based on an article about the APHENITY trial that was published in The Lancet journal in October 2024. The APHENITY trial was a phase 3 clinical trial to find ou...
Effectiveness of motor relearning program in sit-to-stand transfer and activities of daily living among chronic stroke patients - a prospective, multicenter, randomized controlled trial [0.03%]
慢性卒中患者坐位到站起转移和日常生活活动能力的运动再学习方案效果研究：一项前瞻性多中心随机对照试验
Khadijah Abdulrahman Alfaleh,Abdul Rahim Shaik,Karthick Balasubramanian et al.
Khadijah Abdulrahman Alfaleh et al.
Aim: Stroke is a clinically defined syndrome characterized by an acute, focal neurological deficit due to vascular injury. Strokes can result in various disabilities, including sensory and motor abnormalities, leading to difficulties with m...
Simplifying fractional polynomials in Bayesian network meta-analysis via variable powers [0.03%]
通过变量幂简化贝叶斯网状meta分析中的分数多项式
Andre Verhoek,Mario Jnm Ouwens,Bart Heeg et al.
Andre Verhoek et al.
Aim: Fractional Polynomial (FP) models are widely used in survival analysis for health technology assessment and network meta-analysis (NMA). However, current implementations rely on a fixed set of pre-specified powers, which may constrain ...
Health outcomes and costs in patients prescribed anticholinergic medications for overactive bladder [0.03%]
抗胆碱药物治疗过度活跃膀胱患者的健康结局和成本
Holly E Richter,Benjamin Chastek,Adam Carrera et al.
Holly E Richter et al.
Aim: Anticholinergic burden (ACB) is associated with profound clinical and economic burden; however, anticholinergic medications are often prescribed for overactive bladder (OAB). This analysis assessed risk of adverse health outcomes and c...
Evaluating the feasibility of a network meta-analysis comparing treatment options in polycythemia vera [0.03%]
评估网络-meta-分析原发性血小板增多症治疗选择可行性的研究
Paul Walden,Noemi Hummel,Agnieszka Kopiec et al.
Paul Walden et al.
Aim: Polycythemia vera (PV), a rare, chronic myeloproliferative neoplasm, that negatively impacts patient outcomes, and optimal therapy remains unclear due to a lack of head-to-head trials. A targeted literature review and feasibility asses...
Evaluating amyloid-beta as a surrogate endpoint in trials of anti-amyloid-beta drugs in Alzheimer's disease: a Bayesian meta-analysis [0.03%]
对阿尔茨海默病抗淀粉样蛋白药物试验中以淀粉样蛋白-β作为替代终点的评估：一项bayesian元分析
Sa Ren,Janharpreet Singh,Sandro Gsteiger et al.
Sa Ren et al.
Aim: The use of amyloid-beta (Aβ) clearance to support regulatory approvals of drugs in Alzheimer's disease (AD) remains controversial. We evaluate Aβ as a potential trial-level surrogate endpoint for clinical function in AD. Materials & ...
Patient characteristics, burden of disease, healthcare resource utilization and costs in acute myeloid leukemia - a retrospective observational study with German claims data [0.03%]
德国索赔数据的回顾性观察研究中的急性髓系白血病患者的特征、疾病负担、医疗资源利用和成本
Katja Greth,Moritz Lehne,Marco Ghiani et al.
Katja Greth et al.
Aim: To assess patient characteristics, burden of disease, healthcare resource utilization and costs of acute myeloid leukemia (AML) by treatment intensity in German claims data. Materials & methods: In this retrospective cohort study using...
Iron deficiency treatment pathway in Italy: patients' perceptions of diagnosis and treatment [0.03%]
意大利缺铁治疗途径：患者对诊断和治疗的感知
Ovidio Brignoli,Rose-Marie Carneiro,Cécile Fournier et al.
Ovidio Brignoli et al.
Aim: This 2023 online survey assessed the management of patients with iron deficiency anemia/iron deficiency without anemia (IDA/IDWA) in Italy. Materials & methods: The study used the patient's perspective to examine care pathways used to ...
Comparison treatments for basal ganglia hemorrhage: minimally invasive puncture and drainage versus craniotomy versus conservative treatment [0.03%]
基底节区脑出血的微创穿刺引流与开颅血肿清除及保守治疗的对比研究
Tao Tang,Jing Liu,Bo Gao et al.
Tao Tang et al.
Aim: The optimal management strategies for spontaneous intracerebral hemorrhage in the basal ganglia region are still controversial. The purpose of the present study is to evaluate the clinical benefits of craniotomy, minimally invasive pun...
Adherence, treatment utilization, clinical and economic outcomes of patients with sickle cell disease with recurrent vaso-occlusive crises treated with recently approved chronic therapies in the US [0.03%]
美国接受最近批准的慢性疗法治疗的反复出现血管阻塞性危象的镰状细胞病患者的依从性、利用医疗保健情况和临床及经济结果
Chuka Udeze,Michelle Jerry,Kristin Evans et al.
Chuka Udeze et al.
Aim: To describe real-world adherence, treatment utilization, vaso-occlusive crises (VOC) and economic outcomes in patients with sickle cell disease (SCD) with recurrent VOC treated with L-glutamine, voxelotor or crizanlizumab in the US. Ma...