Health utility by Psoriasis Area and Severity Index response status after biologic induction therapy in Chinese patients with moderate to severe psoriasis [0.03%]
生物制剂诱导治疗后中国中重度银屑病患者的PASI应答状态与健康效用价值的关系研究
Lu Jian,Liang Zhang,Guo Zhou et al.
Lu Jian et al.
Aim: Psoriasis severely affects quality of life, particularly in patients with moderate to severe psoriasis. This study aims to estimate health utility by Psoriasis Area and Severity Index (PASI) response after biologic induction therapy in...
Real-word evidence on healthcare resource use and associated costs in on-demand users of replacement therapies in von Willebrand disease in France: the FORvWARD study [0.03%]
法国按需使用血管性血友病因子治疗的患者医疗资源利用及相关成本的真实世界证据：FORvWARD研究
Benoit Polack,Virginie Nerich,Claire Marant Micallef et al.
Benoit Polack et al.
Background: Real-world data about use of Von Willebrand factor (VWF) concentrates to manage on-demand patients with Von Willebrand disease (VWD) are scarce. Aim: To describe and compare patients' characteristics, treatment patterns, healthc...
Target trial emulation: bridging observational studies and randomized trials for health decision-making [0.03%]
目标试验模拟：观察性研究和随机对照试验在医疗决策中的联系与结合
Emilia Riggi,Eva Segelov,Gian Luca Di Tanna
Emilia Riggi
Randomized controlled trials (RCTs) are the gold standard generating evidence owing to their rigorous methodology. However, their logistical, financial and ethical limitations highlight the need for alternative approaches using real-world d...
Indirect treatment comparison of iptacopan versus pegcetacoplan for patients with paroxysmal nocturnal hemoglobinuria and residual anemia despite C5 inhibitor treatment [0.03%]
补体系统C5抑制剂治疗后仍存在残余性贫血的阵发性夜间血红蛋白尿患者的依普司他与佩加斯他间接比较研究
Austin Kulasekararaj,Phillip Scheinberg,Maria-Magdalena Balp et al.
Austin Kulasekararaj et al.
This study conducted an indirect treatment comparison (ITC) of iptacopan, the first oral monotherapy targeting factor B, versus pegcetacoplan, a subcutaneous infusion targeting complement component 3, in patients with paroxysmal nocturnal h...
Comparison of two-stage methods for count data in Mendelian randomization: a simulation study [0.03%]
孟德尔随机化计数数据两阶段方法的比较：一项模拟研究
Mary Appah,Riku Takei,Vinodh Srinivasasainagendra et al.
Mary Appah et al.
Aim: Mendelian randomization (MR) is an instrumental variable (IV) method that utilizes genetic variants to establish causality between risk factors and outcomes in observational studies. These methods were primarily developed under assumpt...
The inaugural HEMA report: a missed opportunity for comprehensive value assessment [0.03%]
首个HEMA报告：错失的进行综合价值评估的机会
Kimberly Westrich,Tyler D Wagner,Jonathan D Campbell
Kimberly Westrich
Cost-effectiveness analysis of the use of faricimab in diabetic macular edema in China [0.03%]
法瑞西单抗治疗中国糖尿病黄斑水肿患者的成本效益分析研究
Fenghao Shi,Shuhua Tan,Yamin Shu et al.
Fenghao Shi et al.
Aim: Diabetic macular edema (DME) is one of the leading causes of vision impairment in diabetic patients. The aim of this study was to evaluate the cost-effectiveness of faricimab (Vabysmo®), the first bispecific antibody targeting VEGF-A ...
Lefamulin versus omadacycline for community acquired bacterial pneumonia: a systematic review and anchored indirect treatment comparison using moxifloxacin as the common comparator [0.03%]
利法敏星与奥马环素治疗社区获得性细菌性肺炎的疗效比较：系统评价和以莫西沙星为共同参比药的锚定间接治疗 comparisons
Meiyu Wu,Sheng Han,Hongchao Li
Meiyu Wu
Aim: Community-acquired bacterial pneumonia (CABP) remains a major cause of morbidity and mortality worldwide, particularly among elderly and susceptible populations. Escalating antimicrobial resistance among prevalent CABP pathogens in Chi...
Personalized management of angina and heart failure in clinical practice in the Middle East: a narrative review [0.03%]
中东地区临床实践中间质性肺病的个性化诊疗：叙述性综述
Juwairia Al Ali,Brajesh Mittal,Fekry El Deeb et al.
Juwairia Al Ali et al.
More interventions that better manage cardiovascular disease are urgently needed in the Middle East. To discuss this issue, we held a symposium at the Heart Masters Middle East 2023 congress (Dubai, UAE; May 2023) on personalized management...
A novel real-world data methodology for lymphoma outcome classification: the real-world Lugano study [0.03%]
一项新颖的淋巴瘤预后分类真实世界数据研究方法：真实世界的Lugano分型研究
Richard Scott Swain,Andrew Klink,Parisa Asgarisabet et al.
Richard Scott Swain et al.
Aim: In oncology trials, blinded independent central review (BICR) is the standard for treatment response classification. Real-world data methodologies that align with BICR may reduce misclassification in real-world evidence (RWE) studies a...