Integrating host-microbiota metabolic networks: how aromatic amino acids shape immune homeostasis and affect disease progression [0.03%]
整合宿主-微生物代谢网络：芳香族氨基酸如何塑造免疫稳态并影响疾病进展
Yanan Zhang,Xinya Zhao,Haoran Wang et al.
Yanan Zhang et al.
Gut microbial metabolism is intimately linked to host immune homeostasis. Aromatic amino acids (AAAs) serve as substrates for both host and microbial enzymes, yielding a diverse array of metabolites that shape immune responses at local and ...
Macrophage USP9X attenuates colitis by restricting oncostatin M production via K27-linked deubiquitination of STAT1 [0.03%]
USP9X通过去泛素化STAT1限制Oncostatin M产生从而减轻巨噬细胞在肠炎中的作用
Tao Zhang,Fanyi Meng,Wenjing Zhao et al.
Tao Zhang et al.
Dysregulated posttranslational modifications drive inflammatory bowel disease (IBD) pathogenesis, yet the specific roles of deubiquitinases in intestinal macrophages remain poorly characterized. Here, we identify ubiquitin-specific peptidas...
Mycobacterium tuberculosis MEM39 (Rv1977) hijacks host aldolase A (ALDOA) to subvert immunometabolism to facilitate bacterial intracellular survival [0.03%]
结核分枝杆菌MEM39（Rv1977）劫持宿主醛缩酶A（ALDOA）以改变免疫代谢并促进细菌的胞内存活
Yuanyuan Zhou,Min Liu,Zilu Qu et al.
Yuanyuan Zhou et al.
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the leading cause of infectious disease-related death. As a major intracellular pathogen, Mtb can escape clearance by the immune system, but the underlying molec...
Srinivasa Reddy Bonam,Suprabhat Mukherjee,Jagadeesh Bayry
Srinivasa Reddy Bonam
Fusobacterium nucleatum-induced mitophagy in macrophages supports intracellular bacterial persistence and promotes esophageal squamous cell carcinoma metastasis [0.03%]
核梭杆菌诱导的巨噬细胞线粒体自噬支持细菌胞内持续存在并促进食管鳞状细胞癌转移
Fangfang Chen,Yulin Liu,Han Xiao et al.
Fangfang Chen et al.
The facultative intracellular bacterium Fusobacterium nucleatum (Fn) promotes tumorigenesis and progression in esophageal squamous cell carcinoma (ESCC). The intracellular survival strategy of Fn and whether Fn can spread through cell‒cell...
TRPV3 facilitates metabolic alarmin-driven humoral immunity: from infection shielding to lupus flares [0.03%]
TRPV3促进代谢报警素驱动的体液免疫：从抗感染到系统性红斑狼疮病情加重
Yuxin Li,Yile E Liu,Jiachen Zhang et al.
Yuxin Li et al.
Mapping the holonomic signaling network that drives pathological changes in endotoxic shock [0.03%]
绘制内毒素休克驱动病理变化的规范信号网络地图
Teng Teng,Xinhe Gao,Peipei Zhang et al.
Teng Teng et al.
Bacterial lipopolysaccharide (LPS) is among the most potent pathogen-associated molecular patterns (PAMPs). In animals, LPS can induce endotoxic shock, a widely used model of sepsis. Studies of this system have yielded important insights in...
Ke Yang,Chunqian Yang,Kai Xiong et al.
Ke Yang et al.
Despite revolutionizing oncology, cancer immunotherapy benefits only a minority of patients partly because of adaptive resistance. This resistance tends to manifest in two distinct clinical scenarios. The first is characterized by disease p...
PARK7-induced delactylation of ATAD3A impairs mitochondrial fitness to promote exhaustion of tumor-infiltrating CD8+ T cells [0.03%]
PARK7诱导的ATAD3A脱乳酸化损害线粒体功能以促进肿瘤浸润CD8⁺T细胞衰竭
Jing Liu,Mengjun Xu,Yi Zhou et al.
Jing Liu et al.
Mitochondrial dysfunction is a critical factor driving the exhaustion of tumor-infiltrating CD8+ T cells and impeding the efficacy of tumor immunotherapy. However, the key regulatory proteins and molecular mechanisms governing mitochondrial...
The alkylation of AIM2 by itaconate mediates macrophage PANoptosis during sepsis [0.03%]
衣康酸对AIM2的乙基化介导了脓毒症期间巨噬细胞的PAN亢死现象
Jiamin Ma,Ying Chen,Pei Wang et al.
Jiamin Ma et al.
Although the immunometabolite itaconate has long been considered an anti-inflammatory, we found that its profound accumulation paradoxically drives macrophage cell death and pro-inflammatory responses. However, the exact molecular mechanism...