Lipid metabolism reprogramming shapes the immune landscape in the tumor microenvironment [0.03%]
脂质代谢重塑塑造肿瘤微环境中的免疫图谱
Yun-Wei Du,Ze-Rong Cai,Xiao-Tong Duan et al.
Yun-Wei Du et al.
Given the fundamental biological importance of lipids not only as structural components and energy substrates but also as potent bioactive molecules that govern immune and oncogenic signaling, lipid metabolism reprogramming has emerged as a...
Acute stress alleviates type 2 lung inflammation by restricting ILC2s through corticosterone-glucocorticoid receptor signaling [0.03%]
急性应激通过皮质酮-糖皮质激素受体信号限制ILC2s以缓解2型肺部炎症
Lin Zhu,Yuying Huang,Bo Peng et al.
Lin Zhu et al.
The psychological state profoundly influences immune responses. While chronic stress is generally known to exacerbate inflammation, the impact of acute stress on inflammation has received far less attention. Here, we report that acute stres...
Persistent IFN-I signaling inhibits mitochondrial oxidative metabolism in CD8+ T cells during HIV-1 infection under cART [0.03%]
在人类免疫缺陷病毒-1感染的限制性治疗期间，持续的IFN-I信号传导抑制CD8⁺ T细胞中的线粒体氧化代谢
Liang Cheng,Guangming Li,Fei Luo et al.
Liang Cheng et al.
Persistent type I interferon (IFN-I) signaling contributes to immune exhaustion and promotes HIV-1 persistence. While we and others have demonstrated that blocking IFN-I signaling in vivo restores anti-HIV-1 T-cell function and reduces vira...
SPT6 maintains epidermal homeostasis by inhibiting an NF-κB-positive feedback loop to prevent excessive inflammation [0.03%]
SPT6通过抑制NF-κB正反馈环防止过度炎症来维持表皮稳态
Yushuang Sun,Shuqia Xu,Dongyu Wang et al.
Yushuang Sun et al.
Keratinocytes are increasingly recognized as central regulators of cutaneous immune responses and key contributors to maintaining immune homeostasis. However, whether and how epidermal stem and progenitor cells (EPSCs) actively suppress pro...
Hendrik Luxenburger,Robert Thimme,Maike Hofmann
Hendrik Luxenburger
Chronic viral infections and cancer challenge immune control by enforcing sustained antigen exposure, which profoundly alters the fate and function of CD8+ T cells. In contrast to acute infections, which induce robust effector differentiati...
Jaewoo Park,SangJoon Lee
Jaewoo Park
Mechanistic impasses: tofacitinib treatment ameliorates GM-CSF-driven macrophage inflammation [0.03%]
机制困境：托法替尼治疗可缓解GM-CSF驱动的巨噬细胞炎症
Felix I L Clanchy
Felix I L Clanchy
Andreas Hutloff
Andreas Hutloff
Anna A Korchagina,Alexei V Tumanov
Anna A Korchagina
Reprogramming the immune orchestra for glioblastoma: oncolytic viruses and the B-cell connection [0.03%]
溶细胞病毒和B细胞在胶质母细胞瘤免疫治疗中的作用关系研究
Costanza Dieli,Marta Di Simone,Francesco Dieli et al.
Costanza Dieli et al.