Short-, medium-, versus long-chain fatty acids: mechanisms of immunomodulation and disease pathogenesis [0.03%]
Chang H Kim
Chang H Kim
Fatty acids, such as short-chain fatty acids, medium-chain fatty acids and long-chain fatty acids, exist in different chain lengths and with various modifications, which determine their physical, metabolic and biological properties. They se...
De novo engineered disulfide bond supersedes native interchain linkage to enhance TCR pairing and anti-tumor efficacy in T cell therapy [0.03%]
Dan Su,Fan Zhu,Hui Shi et al.
Dan Su et al.
T-cell receptor-engineered T (TCR-T) cell therapy is considered highly promising for treating solid tumors. However, it still has significant limitations; one is exogenous-endogenous TCR chain mispairing, which could substantially compromis...
Inhibition of glycosphingolipid synthesis overcomes the steric hindrance of CD30 N-glycans to augment CD30-targeted immunotherapeutic efficacy [0.03%]
Yuting Pan,Yixin Chang,Wanjun Zhang et al.
Yuting Pan et al.
CD30-targeted chimeric antigen receptor (CAR) T-cell therapy faces clinical challenges in classical Hodgkin lymphoma (cHL). While current optimization strategies focus on CAR design, manufacturing protocols, and preconditioning regimens, tu...
Sarah Beyer,Benjamin Ruf
Sarah Beyer
Interleukin enhancer binding factor 3 exacerbates cardiac inflammation and injury following myocardial infarction by inhibiting Lys48-linked ubiquitination on HNRNPA2B1 in macrophages [0.03%]
Xu Zhang,Peng Wang,Long-Hao Liu et al.
Xu Zhang et al.
Changes in the immune microenvironment are key features of ischemic heart disease. In particular, excessive inflammatory responses driven by macrophages are the primary cause of myocardial injury, impaired repair and deterioration of cardia...
EZH2 and intracellular Ca2+ signals interdependently coordinate alloreactive and CAR-T-cell responses [0.03%]
Ying Wang,Qingrong Huang,Yan Zhou et al.
Ying Wang et al.
In graft-versus-host disease (GVHD), Ca2+ signals in alloreactive T cells are carefully controlled to determine whether cells survive or thrive, although how this is accomplished during GVHD remains poorly defined. We demonstrate that EZH2,...
Regulatory heme: a mitochondria-to-nucleus messenger of CD8+ T-cell exhaustion [0.03%]
调节性血红素：CD8⁺T细胞衰竭中的线粒体到细胞核信使
Hao Song,Hao Shi,Hongbo Chi
Hao Song
Construction of an engineered Escherichia coli strain with enhanced intestinal colonization and anti-inflammatory efficacy in colitis [0.03%]
一株用于治疗结肠炎具有更强肠道定植能力和抗炎效果的大肠杆菌工程菌的构建
Peijun Yu,Wenjing Zhou,Chunyang Li et al.
Peijun Yu et al.
Engineered probiotics are considered effective and safe therapeutic strategies for the treatment of various diseases. Escherichia coli Nissle 1917 (EcN) has been widely used as a chassis strain because of its safety and well-established gen...
MAIT cell plasticity generates CD4+ MAIT cells that promote HCC progression via metabolic crosstalk with tumor cells [0.03%]
MAIT细胞的可塑性通过与肿瘤细胞的代谢互作产生CD4+MAIT细胞从而促进肝癌进展
Sicheng Fu,Maoyu Tang,Changfeng Zhao et al.
Sicheng Fu et al.
Mucosal-associated invariant T cells (MAITs) are enriched in the liver and closely related to human hepatocellular carcinoma (HCC), but their role is controversial. Whether and how the plasticity of MAITs modulates HCC progression remain to...
Hepatocyte-derived LRG1 primes the liver for metastasis and impairs immunotherapy [0.03%]
肝细胞源LRG1诱导肝脏转移并影响免疫治疗
Guojie Long,Bing Cheng,Yue Jiang et al.
Guojie Long et al.
The liver undergoes active remodeling by the primary tumor prior to metastatic spread. However, the mechanisms by which hepatocytes dictate the liver-specific tropism of tumors remain elusive. Here, we identify hepatocyte-derived leucine-ri...