Platelet-derived serotonin epigenetically programs macrophage alternative activation to orchestrate type 2 airway inflammation [0.03%]
血小板源性血清素表观遗传学编程巨噬细胞替代活化以协调2型气道炎症
Ru Tang,Guofang Xia,Ying Zhu et al.
Ru Tang et al.
Type 2 inflammation (T2I) drives chronic airway diseases such as eosinophilic chronic rhinosinusitis (eCRS) and asthma, which are frequently accompanied by coagulation activation and platelet recruitment. However, whether and how these asso...
NLRC3 enhances antitumor immunity by specifically negatively regulating M-MDSCs in a STING-dependent manner [0.03%]
NLRC3通过STING依赖性机制特异性抑制M-MDSCs从而增强抗肿瘤免疫反应
Yuling Fu,Xiaoxia Zhan,Shousheng Liu et al.
Yuling Fu et al.
NOD-like receptor (NLR) family CARD domain containing 3 (NLRC3), an intracellular member of the NLR family, is a negative regulator of both immune cell modulation and tumor cell proliferation. However, the role of NLRC3 and the mechanisms u...
Tumor cell-released autophagosome (TRAP) programs inflammatory CAFs to drive the immune-excluded TIME through C3a [0.03%]
肿瘤细胞释放的自噬小体(TRAP)通过C3a编程炎性CAFs以驱动免疫排除型TIME
Xuru Wang,Yiting Wei,Chengdong Wu et al.
Xuru Wang et al.
The immune-excluded tumor immune microenvironment (TIME) limits responses to ICIs. Cancer-associated fibroblasts are the most abundant stromal population and key regulators of immune suppression; however, the upstream cues that program path...
Author Correction: DNA sensing and associated type 1 interferon signaling contributes to progression of radiation-induced liver injury [0.03%]
作者更正：DNA感应和I型干扰素信号传导促成了放射引起的肝损伤的发展
Shisuo Du,Genwen Chen,Baoying Yuan et al.
Shisuo Du et al.
Published Erratum
Cellular & molecular immunology. 2026 Jul 17. DOI:10.1038/s41423-026-01449-0 2026
The Parkinson's disease-linked G2019S mutation of LRRK2 increases NADPH oxidase-2 activity in neutrophils for superior control of bacterial infections [0.03%]
帕金森氏症相关的LRRK2突变体G2019S通过增加中性粒细胞中的NADPH氧化酶活性以增强对细菌感染的控制作用
Kate Hurley,Rachel Kaul,Sahil Yadav et al.
Kate Hurley et al.
Allelic variants in the leucine-rich repeat kinase-2 (LRRK2) gene are linked to Parkinson's disease, Crohn's disease and leprosy; however, a consensus role of LRRK2 in infection has not yet emerged. Parkinson's disease-linked p.G2019S mutat...
Macrophage CCRL2 promotes NLRP3 inflammasome activation to exacerbate atherosclerosis [0.03%]
巨噬细胞CCRL2促进NLRP3炎性小体活化从而恶化动脉粥样硬化
Qian Cai,Zhen Duan,Zhongwei Yang et al.
Qian Cai et al.
Atherosclerotic lesions contain heterogeneous macrophage populations with divergent functional phenotypes that play opposing roles in disease progression, creating a major obstacle for the development of macrophage-targeted therapy. The ide...
Unifying the hallmarks of major depression through neuroimmune-metabolic-oxidative (NIMETOX) dysregulation: a mechanistic systems framework [0.03%]
通过神经免疫-代谢-氧化(NIMETOX)失调统一主要抑郁症的标志：一种机制系统框架
Michael Maes,Abbas F Almulla,Drozdstoj Stoyanov et al.
Michael Maes et al.
Current state-of-the-art neuroimmune, metabolic, and oxidative stress (NIMETOX) knowledge that has been developed in clinical major depressive disorder (MDD) research over the past three decades is explored in this review. Between 1990 and ...
FAM234A acts as a switch between Th17 and Treg cell fate decisions that control inflammatory bowel disease [0.03%]
FAM234A充当Th17和Treg细胞命运决定的开关以控制炎症性肠病
Zhaoqi Zhang,Chenxu Zhao,Lingyun Sun et al.
Zhaoqi Zhang et al.
Appropriate T-cell functional polarization is critical for maintaining immune stability and immune tolerance. The role of Fam234a in the functional polarization of T cells is unknown. In a DSS-induced inflammatory bowel disease model in Rag...
Liangzhan Sun,Zemin Zhang
Liangzhan Sun
USP9X trims STAT1 to curb oncostatin M activity and intestinal inflammation [0.03%]
USP9X通过修剪STAT1来限制 Oncostatin M 的活性及其介导的肠道炎症反应
Ahmed N Hegazy
Ahmed N Hegazy