USP9X trims STAT1 to curb oncostatin M activity and intestinal inflammation [0.03%]
USP9X通过修剪STAT1来限制 Oncostatin M 的活性及其介导的肠道炎症反应
Ahmed N Hegazy
Ahmed N Hegazy
Itaconate induces noncanonical AIM2-dependent PANoptosis in sepsis [0.03%]
异丙酸诱导非经典的AIM2依赖性的PANoptosis抗败血症作用
Hayeon Kim,SangJoon Lee
Hayeon Kim
SeongBeom Kim,SangJoon Lee
SeongBeom Kim
Vimentin trogocytosis as a novel mechanism of NK cell exhaustion by circulating tumor cells [0.03%]
循环肿瘤细胞通过波形蛋白trogocytosis诱导NK细胞衰竭的新机制
Hyo-Jeong Cha,Changwan Hong
Hyo-Jeong Cha
TGF-β and IL-2 differentially shape T follicular regulatory cell differentiation and stability in vitro [0.03%]
TGF-β和IL-2体外区别地调节Tfr细胞的分化及稳定性
Luisa Bach,Yinshui Chang,Olin Arteaga Transito et al.
Luisa Bach et al.
T follicular helper (Tfh) cells and T follicular regulatory (Tfr) cells play critical roles in regulating the activity of the germinal center (GC), which is essential for the generation of high-affinity antibodies. In the GC, Tfh cells help...
Sympathetic immunomodulation suppresses liver metastasis by maintaining the balance between norepinephrine concentration and the α2a/β2-AR ratio [0.03%]
肾上腺素浓度与α2a/β2-AR比例的平衡调控协同免疫调节抑制肝转移
Lulu Gao,Jian Li,Borui Li et al.
Lulu Gao et al.
The sympathetic nervous system (SNS) plays a crucial role in chronic liver diseases, but its function, particularly in terms of the underlying mechanisms of liver metastasis, remains unclear. Here, we reported that hepatic sympathetic nerve...
Acquisition of Vimentin by trogocytosis inhibits the NK cell-mediated immune response against circulating tumour cells (CTCs) [0.03%]
通过吞饮获得波形蛋白抑制NK细胞介导的循环肿瘤细胞免疫反应
Lu Zhao,Ran Li,Xiao-Yan Meng et al.
Lu Zhao et al.
Natural killer (NK) cells frequently exhibit an exhausted state, which facilitates immune escape of circulating tumor cells (CTCs). However, the underlying mechanisms of NK cell dysfunction remain elusive. In this study, we identified a nov...
Fibroblast-derived CCL2 orchestrates immune responses and defends against Staphylococcus aureus skin infection [0.03%]
成纤维细胞衍生的CCL2调控免疫反应并防御金黄色葡萄球菌皮肤感染
Tatsuya Dokoshi,Marta Palomo-Irigoyen,Kazuki Dai et al.
Tatsuya Dokoshi et al.
Host defense against invasive bacterial infections of the skin is essential for survival. It involves a complex yet incompletely understood process of microbial recognition followed by innate and adaptive systems for communication between r...
A cholinergic checkpoint controls autoantibody selection via somatic hypermutation in lupus germinal centers [0.03%]
胆碱能检查点通过狼疮生发中心中的体细胞超突变控制自身抗体的选择性
Jin Li,Yimei Lai,Huijin Zou et al.
Jin Li et al.
Systemic lupus erythematosus (SLE) pathogenesis involves the dysregulated production of mutated, high-affinity autoantibodies, a process primarily orchestrated within germinal centers (GCs). However, the precise regulatory mechanisms govern...
Microglia and neuroinflammation: function, heterogeneity, and crosstalk [0.03%]
小胶质细胞与神经炎症：功能、异质性和串扰
Shuai Zong,Xiaolin Cui,Shuang Wu et al.
Shuai Zong et al.
Microglia, the resident innate immune cells of the central nervous system (CNS), are indispensable for maintaining brain homeostasis, conducting immune surveillance, and responding to injury. Recent single-cell sequencing studies have revea...