Is freezing of gait in Parkinson's disease a result of multiple gait impairments? Implications for treatment [0.03%]
帕金森病的步态冻结是多种步行障碍的结果吗？对治疗的意义
Meir Plotnik,Nir Giladi,Jeffrey M Hausdorff
Meir Plotnik
Several gait impairments have been associated with freezing of gait (FOG) in patients with Parkinson's disease (PD). These include deteriorations in rhythm control, gait symmetry, bilateral coordination of gait, dynamic postural control and...
The neuroprotective disease-modifying potential of psychotropics in Parkinson's disease [0.03%]
精神活性药物对帕金森病的神经保护和疾病修饰潜力
Edward C Lauterbach,Leonardo F Fontenelle,Antonio L Teixeira
Edward C Lauterbach
Neuroprotective treatments in Parkinson's disease (PD) have remained elusive. Psychotropics are commonly prescribed in PD without regard to their pathobiological effects. The authors investigated the effects of psychotropics on pathobiologi...
Critical aspects of clinical trial design for novel cell and gene therapies [0.03%]
新型细胞和基因疗法临床试验设计的关键方面
Zinovia Kefalopoulou,Iciar Aviles-Olmos,Thomas Foltynie
Zinovia Kefalopoulou
Neural cell transplantation and gene therapy have attracted considerable interest as promising therapeutic alternatives for patients with Parkinson's disease (PD). Preclinical and open-label studies have suggested that grafted fetal neural ...
Carlos Barcia,Stéphane Hunot,Gilles J Guillemin et al.
Carlos Barcia et al.
Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS: A Pilot Study [0.03%]
单侧脑深部刺激对帕金森病非运动症状的影响：一项初步研究
Nelson Hwynn,Ihtsham Ul Haq,Irene A Malaty et al.
Nelson Hwynn et al.
Parkinson's disease (PD) management has traditionally focused largely on motor symptoms. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are effective treatments for motor symptoms. Nonmotor ...
Yuzuru Imai,Katerina Venderova,David S Park et al.
Yuzuru Imai et al.
Bruce Murdoch,Tara Whitehill,Miet de Letter et al.
Bruce Murdoch et al.
Yelena Bogdanova,Alice Cronin-Golomb
Yelena Bogdanova
Parkinson's disease (PD) is associated with various nonmotor symptoms including neuropsychiatric and cognitive dysfunction. We examined the relation between apathy, anxiety, side of onset of motor symptoms, and cognition in PD. We hypothesi...
Robyn M Lamont,Meg E Morris,Marjorie H Woollacott et al.
Robyn M Lamont et al.
People with Parkinson's disease often have walking difficulty, and this is likely to be exacerbated while walking in places in the community, where people are likely to face greater and more varied challenges. This study aims to understand ...
Exercise and motor training in people with Parkinson's disease: a systematic review of participant characteristics, intervention delivery, retention rates, adherence, and adverse events in clinical trials [0.03%]
帕金森病患者运动和功能训练的临床试验系统评价：参与者的特征、干预措施的交付、保留率、依从性和不良事件
Natalie E Allen,Catherine Sherrington,Gayanthi D Suriyarachchi et al.
Natalie E Allen et al.
There is research evidence that exercise and motor training are beneficial for people with Parkinson's disease (PD), and clinicians seek to implement optimal programs. This paper summarizes important factors about the nature and reporting o...