Rachel Denyer,Michael R Douglas
Rachel Denyer
Current pharmacological and surgical treatments for Parkinson's disease offer symptomatic improvements to those suffering from this incurable degenerative neurological disorder, but none of these has convincingly shown effects on disease pr...
Antonio L Teixeira,Leonardo F Fontenelle,Edward C Lauterbach et al.
Antonio L Teixeira et al.
Dementia in Parkinson's Disease Correlates with α-Synuclein Pathology but Not with Cortical Astrogliosis [0.03%]
帕金森病痴呆与α-突触核蛋白病理改变相关但不伴皮质星形胶质细胞增生
Simone A van den Berge,Josta T Kevenaar,Jacqueline A Sluijs et al.
Simone A van den Berge et al.
Dementia is a common feature in Parkinson's disease (PD) and is considered to be the result of limbic and cortical Lewy bodies and/or Alzheimer changes. Astrogliosis may also affect the development of dementia, since it correlates well with...
Metacognitive Performance, the Tip-of-Tongue Experience, Is Not Disrupted in Parkinsonian Patients [0.03%]
帕金森病患者元认知表现并未受损
Justin D Oh-Lee,Sarah M Szymkowicz,Stefanie L Smith et al.
Justin D Oh-Lee et al.
The present study investigated whether a form of metamemory, the tip-of-tongue phenomenon (TOT), was affected in patients with Parkinson's disease (PD). The PD patient (n = 22), age-matched elderly control (n = 22), and college student cont...
Brendan J Kelley,Andrew P Duker,Peter Chiu
Brendan J Kelley
The dopamine agonists ropinirole and pramipexole exhibit highly specific affinity for the cerebral dopamine D3 receptor. Use of these medications in Parkinson's disease has been complicated by the emergence of pathologic behavioral patterns...
Gammon M Earhart,Terry Ellis,Alice Nieuwboer et al.
Gammon M Earhart et al.
Neuroinflammation in Parkinson's Disease and Related Disorders: A Lesson from Genetically Manipulated Mouse Models of α-Synucleinopathies [0.03%]
遗传操作的α-突触核蛋白病小鼠模型在帕金森病及相关疾病中的神经炎症研究给我们的启示
Kazunari Sekiyama,Shuei Sugama,Masayo Fujita et al.
Kazunari Sekiyama et al.
Neuroinflammation in Parkinson's disease (PD) is a chronic process that is associated with alteration of glial cells, including astrocytes and microglia. However, the precise mechanisms remain obscure. To better understand neuroinflammation...
Ryan M Welchko,Xavier T Lévêque,Gary L Dunbar
Ryan M Welchko
Parkinson's disease (PD) is a neurodegenerative disease characterized by a specific loss of dopaminergic neurons. Although the vast majority of PD cases are idiopathic in nature, there is a subset that contains genetic links. Of the genes t...
Pascal F Durrenberger,Edna Grünblatt,Francesca S Fernando et al.
Pascal F Durrenberger et al.
The aetiology of Parkinson's disease (PD) is yet to be fully understood but it is becoming more and more evident that neuronal cell death may be multifactorial in essence. The main focus of PD research is to better understand substantia nig...
Irena Rektorova,Dag Aarsland,K Ray Chaudhuri et al.
Irena Rektorova et al.