Nicola Tambasco,Simone Simoni,Erica Marsili et al.
Nicola Tambasco et al.
In Parkinson's disease, one of the most troublesome dilemmas is the treatment of levodopa-induced dyskinesia. After a few years, chronic treatment with levodopa is associated with the development of dyskinesias. Strategies to delay or to re...
The anticholinesterase phenserine and its enantiomer posiphen as 5'untranslated-region-directed translation blockers of the Parkinson's alpha synuclein expression [0.03%]
抗胆碱酯酶药物phenserine及其对映异构体posiphen通过抑制5'-非翻译区起始翻译来减少帕金森病α突触核蛋白的表达
Sohan Mikkilineni,Ippolita Cantuti-Castelvetri,Catherine M Cahill et al.
Sohan Mikkilineni et al.
There is compelling support for limiting expression of alpha-synuclein (α-syn) in the brains of Parkinson's disease (PD) patients. An increase of SNCA gene copy number can genetically cause familial PD where increased dose of this pathogen...
Psychosis assessment in early-stage Parkinson's disease: comparing Parkinson's psychosis questionnaire with the brief psychiatric rating scale in a portuguese sample [0.03%]
早期帕金森病的精神病评估：在葡萄牙样本中比较帕金森氏精神病问卷与简明精神状态评价量表
I Cargaleiro,M Serra,J Alves da Silva et al.
I Cargaleiro et al.
Psychotic symptoms in Parkinson's disease (PD) are frequent, disabling, and an important prognostic factor. Thus, screening instruments for detecting psychosis in PD are needed. For this purpose, we applied the Parkinson's Psychosis Questio...
Iciar Aviles-Olmos,Zinovia Kefalopoulou,Thomas Foltynie
Iciar Aviles-Olmos
L-dopa is the most effective, currently available treatment for Parkinson's disease (PD), but it leads to the development of involuntary movements known as L-dopa-induced dyskinesia (LID) in the majority of patients after long-term use. Bot...
The prevalence of fatigue following deep brain stimulation surgery in Parkinson's disease and association with quality of life [0.03%]
帕金森病深部脑刺激术后疲劳的患病率及其与生活质量的关系
Benzi M Kluger,Veronica Parra,Charles Jacobson et al.
Benzi M Kluger et al.
Fatigue is a common and disabling nonmotor symptom seen in Parkinson's disease (PD). While deep brain stimulation surgery (DBS) improves motor symptoms, it has also been associated with non-motor side effects. To date no study has utilized ...
The emerging role of proteolysis in mitochondrial quality control and the etiology of Parkinson's disease [0.03%]
蛋白酶体在线粒体质量控制及帕金森病发病机制中的作用
Riya Shanbhag,Guang Shi,Jarungjit Rujiviphat et al.
Riya Shanbhag et al.
Mitochondria are highly dynamic organelles that are important for many diverse cellular processes, such as energy metabolism, calcium buffering, and apoptosis. Mitochondrial biology and dysfunction have recently been linked to different typ...
A possible novel anti-inflammatory mechanism for the pharmacological prolyl hydroxylase inhibitor 3,4-dihydroxybenzoate: implications for use as a therapeutic for Parkinson's disease [0.03%]
3,4-二羟基苯甲酸作为药理学脯氨酰羟化酶抑制剂的可能性新抗炎机制及其作为帕金森病治疗药物的潜在用途
Shankar J Chinta,Subramanian Rajagopalan,Abirami Ganesan et al.
Shankar J Chinta et al.
Parkinson's disease (PD) is an age-related neurodegenerative disorder characterized in part by the preferential loss of nigrostriatal dopaminergic neurons. Although the precise etiology of PD is unknown, accumulating evidence suggests that ...
Corticostriatal Plastic Changes in Experimental L-DOPA-Induced Dyskinesia [0.03%]
左旋多巴诱发的运动障碍模型中的皮质纹状体可塑性改变
Veronica Ghiglieri,Vincenza Bagetta,Valentina Pendolino et al.
Veronica Ghiglieri et al.
In Parkinson's disease (PD), alteration of dopamine- (DA-) dependent striatal functions and pulsatile stimulation of DA receptors caused by the discontinuous administration of levodopa (L-DOPA) lead to a complex cascade of events affecting ...
Patterns of Cell Activity in the Subthalamic Region Associated with the Neuroprotective Action of Near-Infrared Light Treatment in MPTP-Treated Mice [0.03%]
近红外光治疗在MPDP诱导的小鼠中与神经保护作用相关的亚丘脑区域细胞活性模式
Victoria E Shaw,Cassandra Peoples,Sharon Spana et al.
Victoria E Shaw et al.
We have shown previously that near-infrared light (NIr) treatment or photobiomodulation neuroprotects dopaminergic cells in substantia nigra pars compacta (SNc) from degeneration induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP...
Magnolol Protects against MPTP/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson's Disease [0.03%]
magnolol通过抑制氧化应激保护帕金森病的体内和体外模型免受MPTP / MPP（+）诱导的毒性作用
Akiko Muroyama,Aya Fujita,Cheng Lv et al.
Akiko Muroyama et al.
The aim of this study is to investigate the role of magnolol in preventing 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP-) induced neurodegeneration in mice and 1-methyl-4-phenylpyridinium ion-(MPP(+)-) induced cytotoxicity to human ne...