Confirmatory factor analysis of the motor unified Parkinson's disease rating scale [0.03%]
帕金森病综合评价量表的验证性因素分析
Stefanie D Vassar,Yvette M Bordelon,Ron D Hays et al.
Stefanie D Vassar et al.
The motor examination section of the unified Parkinson's disease rating scale (UPDRS) is widely used in research but few studies have examined whether subscales exist that tap relatively distinct motor abnormalities. We analyzed data from 1...
Clinical features, pathophysiology, and treatment of levodopa-induced dyskinesias in Parkinson's disease [0.03%]
帕金森病左旋多巴诱导的异动症的临床特征、发病机制和治疗
J Guridi,R González-Redondo,J A Obeso
J Guridi
Dyskinetic disorders are characterized by excess of motor activity that may interfere with normal movement control. In patients with Parkinson's disease, the chronic levodopa treatment induces dyskinetic movements known as levodopa-induced ...
Ana María Sánchez-Pérez,Berta Claramonte-Clausell,Juan Vicente Sánchez-Andrés et al.
Ana María Sánchez-Pérez et al.
It is generally accepted that a correlation between neurodegenerative disease and protein aggregation in the brain exists; however, a causal relationship has not been elucidated. In neurons, failure of autophagy may result in the accumulati...
N-Acetyl Cysteine Protects against Methamphetamine-Induced Dopaminergic Neurodegeneration via Modulation of Redox Status and Autophagy in Dopaminergic Cells [0.03%]
N-乙酰半胱氨酸通过调节氧化还原状态和自噬作用保护多巴胺能神经元免受麻精药品诱导的神经退行性病变损伤
Prashanth Chandramani Shivalingappa,Huajun Jin,Vellareddy Anantharam et al.
Prashanth Chandramani Shivalingappa et al.
Methamphetamine- (MA-) induced neurotoxicity is associated with mitochondrial dysfunction and enhanced oxidative stress. Our previous study demonstrated that MA induces autophagy in a dopaminergic neuronal cell model (N27 cells). The cellul...
17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) Is Neuroprotective and Reduces Motor Impairment and Neuroinflammation in a Murine MPTP Model of Parkinson's Disease [0.03%]
17α-乙炔-雄甾-5-烯-3β，7β，17β-三醇（HE3286）可保护神经元并减轻小鼠莫达菲尼帕模型中帕金森病的运动障碍和神经炎症
Ferdinando Nicoletti,Ingrid Philippens,Paolo Fagone et al.
Ferdinando Nicoletti et al.
17α-Ethynyl-androst-5-ene-3β,7β,17β-triol (HE3286) is a synthetic androstenetriol in Phase II clinical development for the treatment of inflammatory diseases. HE3286 was evaluated for blood-brain barrier (BBB) permeability in mice, and ...
Yuzuru Imai,Katerina Venderova,Kah-Leong Lim
Yuzuru Imai
David K Simon,Charleen T Chu,Russell H Swerdlow
David K Simon
Neuropsychiatric symptoms in Parkinson's disease with mild cognitive impairment and dementia [0.03%]
帕金森病伴轻度认知障碍和痴呆的精神症状
Iracema Leroi,Hiranmayi Pantula,Kathryn McDonald et al.
Iracema Leroi et al.
Neuropsychiatric symptoms commonly complicate Parkinson's disease (PD), however the presence of such symptoms in mild cognitive impairment (PD-MCI) specifically has not yet been well described. The objective of this study was to examine and...
Parkinson's disease: leucine-rich repeat kinase 2 and autophagy, intimate enemies [0.03%]
帕金森病：Leu-rich repeat激酶2与自噬——互为仇敌
José M Bravo-San Pedro,Rubén Gómez-Sánchez,Elisa Pizarro-Estrella et al.
José M Bravo-San Pedro et al.
Parkinson's disease is the second common neurodegenerative disorder, after Alzheimer's disease. It is a clinical syndrome characterized by loss of dopamine-generating cells in the substancia nigra, a region of the midbrain. The etiology of ...
Patricia Muñoz,Sandro Huenchuguala,Irmgard Paris et al.
Patricia Muñoz et al.
The molecular mechanisms involved in the neurodegenerative process of Parkinson's disease remain unclear. Currently, there is a general agreement that mitochondrial dysfunction, α-synuclein aggregation, oxidative stress, neuroinflammation,...