Inhibition of poly (ADP-Ribose) polymerase-1 in telomerase deficient mouse embryonic fibroblasts increases arsenite-induced genome instability [0.03%]
缺端粒酶的小鼠胚胎纤维细胞中抑制多（ADP-核糖）聚合酶-1增加砷诱导的基因组不稳定性
Resham L Gurung,Lakshmidevi Balakrishnan,Rabindra N Bhattacharjee et al.
Resham L Gurung et al.
Background: The telomerase enzyme is a viable target for anti-cancer therapy given the innate differences in telomerase activity between tumour cells and normal somatic cells. However, the time lag between telomerase inhi...
Localization of an hTERT repressor region on human chromosome 3p21.3 using chromosome engineering [0.03%]
利用染色体工程在人类染色体3p21.3上定位hTERT抑制区域
Satoshi Abe,Hiromi Tanaka,Tomomi Notsu et al.
Satoshi Abe et al.
Telomerase is a ribonucleoprotein enzyme that synthesizes telomeric DNA. The reactivation of telomerase activity by aberrant upregulation/expression of its catalytic subunit hTERT is a major pathway in human tumorigenesis. However, regulato...
Razqallah Hakem,M Prakash Hande,John Petrini et al.
Razqallah Hakem et al.