Emerging role of radiation induced bystander effects: Cell communications and carcinogenesis [0.03%]
辐射诱导旁观者效应的出现：细胞通讯与致癌作用
Rajamanickam Baskar
Rajamanickam Baskar
Ionizing radiation is an invaluable diagnostic and treatment tool used in various clinical applications. On the other hand, radiation is a known cytotoxic with a potential DNA damaging and carcinogenic effects. However, the biological effec...
Kristina Jansson,Anders Blomberg,Per Sunnerhagen et al.
Kristina Jansson et al.
Background: We have examined the phylogenetic pattern among eukaryotes of homologues of the E. coli 7,8-dihydro-8-oxoguanine (8-oxo-G) repair enzymes MutY, MutM, and MutT. ...
Nutriomes and nutrient arrays - the key to personalised nutrition for DNA damage prevention and cancer growth control [0.03%]
营养组分和营养素阵列——用于DNA损伤预防和癌症生长控制的个性化营养的关键因素
Michael F Fenech
Michael F Fenech
DNA damage at the base-sequence, epigenome and chromosome level is a fundamental cause of developmental and degenerative diseases. Multiple micronutrients and their interactions with the inherited and/or acquired genome determine DNA damage...
Image-based quantitative determination of DNA damage signal reveals a threshold for G2 checkpoint activation in response to ionizing radiation [0.03%]
基于图像的DNA损伤定量测定显示离子辐射诱发G2检查点激活存在阈值效应
Aya Ishikawa,Motohiro Yamauchi,Keiji Suzuki et al.
Aya Ishikawa et al.
Background: Proteins involved in the DNA damage response accumulate as microscopically-visible nuclear foci on the chromatin flanking DNA double-strand breaks (DSBs). As growth of ionizing radiation (IR)-induced foci ampl...
Low levels of ATM in breast cancer patients with clinical radiosensitivity [0.03%]
放射敏感乳腺癌患者的ATM蛋白低表达水平
Zhiming Fang,Sergei Kozlov,Michael J McKay et al.
Zhiming Fang et al.
Background and purpose: Adjuvant radiotherapy for cancer can result in severe adverse side effects for normal tissues. In this respect, individuals with anomalies of the ATM (ataxia telangiectasia) protein/gene are of par...
Radiation-induced DNA damage and repair in human gammadelta and alphabeta T-lymphocytes analysed by the alkaline comet assay [0.03%]
彗星实验分析人γδ和αβT淋巴细胞的放射诱导DNA损伤及修复
Halina Lisowska,Marta Deperas-Kaminska,Siamak Haghdoost et al.
Halina Lisowska et al.
It has been shown by a number of authors that the radiosensitivity of peripheral blood mononuclear cells (PBMC) is higher in cancer patients compared to healthy donors, which is interpreted as a sign of genomic instability. PBMC are compose...
UHRF1 is a genome caretaker that facilitates the DNA damage response to gamma-irradiation [0.03%]
UHRF1是一种基因组管家蛋白，可促进γ辐照引起的DNA损伤应对反应
Helena Mistry,Laura Tamblyn,Hussein Butt et al.
Helena Mistry et al.
Background: DNA double-strand breaks (DSBs) caused by ionizing radiation or by the stalling of DNA replication forks are among the most deleterious forms of DNA damage. The ability of cells to recognize and repair DSBs re...
Eukaryotic gene invasion by a bacterial mobile insertion sequence element IS2 during cloning into a plasmid vector [0.03%]
一类细菌可移动插入序列元件IS2在克隆到质粒载体时侵入真核基因
Alireza G Senejani,Joann B Sweasy
Alireza G Senejani
Escherichia coli (E. coli) are commonly used as hosts for DNA cloning and sequencing. Upon transformation of E. coli with recombined vector carrying a gene of interest, the bacteria multiply the gene of interest while maintaining the integr...
Requirement of ATM-dependent pathway for the repair of a subset of DNA double strand breaks created by restriction endonucleases [0.03%]
一小部分限制性内切酶诱导的DNA双链断裂的修复需要ATM依赖途径
Keiji Suzuki,Maiko Takahashi,Yasuyoshi Oka et al.
Keiji Suzuki et al.
Background: DNA double strand breaks induced by DNA damaging agents, such ionizing radiation, are repaired by multiple DNA repair pathways including non-homologous end-joining (NHEJ) repair and homologous recombination (H...
Hemad Yasaei,Predrag Slijepcevic
Hemad Yasaei
Background: Repair of DNA double strand breaks by non-homologous end joining (NHEJ) requires several proteins including Ku, DNA-PKcs, Artemis, XRCC4, Ligase IV and XLF. Two of these proteins, namely Ku and DNA-PKcs, are a...