Cellular Senescence - its role in cancer and the response to ionizing radiation [0.03%]
细胞衰老及其在癌症和电离辐射反应中的作用
Rebecca J Sabin,Rhona M Anderson
Rebecca J Sabin
Cellular senescence is a normal biological process that is initiated in response to a range of intrinsic and extrinsic factors that functions to remove irreparable damage and therefore potentially harmful cells, from the proliferative pool....
Assessment of genome integrity with array CGH in cattle transgenic cell lines produced by homologous recombination and somatic cell cloning [0.03%]
同源重组和体细胞克隆产生的牛转基因细胞系的阵列CGH基因组完整性评估
George E Liu,Yali Hou,James M Robl et al.
George E Liu et al.
Background: Transgenic cattle carrying multiple genomic modifications have been produced by serial rounds of somatic cell chromatin transfer (cloning) of sequentially genetically targeted somatic cells. However, cloning e...
Aurora Ruiz-Herrera,Alexandra Smirnova,Lela Khoriauli et al.
Aurora Ruiz-Herrera et al.
Background: In mammalian cells gene amplification is a common manifestation of genome instability promoted by DNA double-strand breaks (DSBs). The repair of DSBs mainly occurs through two mechanisms: non-homologous end-jo...
Fanconi anemia protein FANCD2 inhibits TRF1 polyADP-ribosylation through tankyrase1-dependent manner [0.03%]
Fanconi贫血症蛋白FANCD2通过tankyrase1依赖性方式抑制TRF1的聚ADP-核糖化反应
Alex Lyakhovich,Maria Jose Ramirez,Andres Castellanos et al.
Alex Lyakhovich et al.
Background: Fanconi anemia (FA) is a rare autosomal recessive syndrome characterized by developmental abnormalities, progressive bone marrow failure, and predisposition to cancer. The key FA protein FANCD2 crosstalks with...
Evaluation of the efficacy of radiation-modifying compounds using γH2AX as a molecular marker of DNA double-strand breaks [0.03%]
基于γH2AX的DNA双链断裂分子标志物筛选辐射改性化合物效力评估模型
Li-Jeen Mah,Christian Orlowski,Katherine Ververis et al.
Li-Jeen Mah et al.
Radiation therapy is a widely used therapeutic approach for cancer. To improve the efficacy of radiotherapy there is an intense interest in combining this modality with two broad classes of compounds, radiosensitizers and radioprotectors. T...
Single- and double-stranded DNA binding proteins act in concert to conserve a telomeric DNA core sequence [0.03%]
单链和双链DNA结合蛋白协同作用以保持端粒DNA核心序列的稳定性
Jenny Rhodin Edsö,Cecilia Gustafsson,Marita Cohn
Jenny Rhodin Edsö
Background: Telomeres are protective cap structures at the ends of the linear eukaryotic chromosomes, which provide stability to the genome by shielding from degradation and chromosome fusions. The cap consists of telomer...
ATM mediated phosphorylation of CHD4 contributes to genome maintenance [0.03%]
ATM介导的CHD4磷酸化在基因组维持中的作用
Aaron J Urquhart,Magtouf Gatei,Derek J Richard et al.
Aaron J Urquhart et al.
Background: In order to maintain cellular viability and genetic integrity cells must respond quickly following the induction of cytotoxic double strand DNA breaks (DSB). This response requires a number of processes includ...
Hydrogen peroxide induced genomic instability in nucleotide excision repair-deficient lymphoblastoid cells [0.03%]
羟基自由基诱导的核苷酸切除修复缺陷淋巴母细胞系中的基因组不稳定性
Kalpana Gopalakrishnan,Grace Kah Mun Low,Aloysius Poh Leong Ting et al.
Kalpana Gopalakrishnan et al.
Background: The Nucleotide Excision Repair (NER) pathway specialises in UV-induced DNA damage repair. Inherited defects in the NER can predispose individuals to Xeroderma Pigmentosum (XP). UV-induced DNA damage cannot acc...
Toshiyuki Bohgaki,Miyuki Bohgaki,Razqallah Hakem
Toshiyuki Bohgaki
DNA double-strand breaks are among the most serious types of DNA damage and their signaling and repair is critical for all cells and organisms. The repair of both induced and programmed DNA breaks is fundamental as demonstrated by the many ...
Time to bloom [0.03%]
花开时节
Shweta Tikoo,Sagar Sengupta
Shweta Tikoo
Bloom Syndrome (BS) is an autosomal recessive disorder due to mutation in Bloom helicase (referred in literature either as BLM helicase or BLM). Patients with BS are predisposed to almost all forms of cancer. BS patients are even today diag...