Danielle L Daee,Kyungjae Myung
Danielle L Daee
Interstrand crosslinks covalently link complementary DNA strands, block replication and transcription, and can trigger cell death. In eukaryotic systems several pathways, including the Fanconi Anemia pathway, are involved in repairing inter...
Dysfunctional telomeres in primary cells from Fanconi anemia FANCD2 patients [0.03%]
芳尼科贫血病FANCD2患者原代细胞的染色体端粒功能异常
Ivana Joksic,Dragana Vujic,Marija Guc-Scekic et al.
Ivana Joksic et al.
Background: Fanconi anemia (FA) is characterized by sensitivity to DNA cross-linking agents, mild cellular, and marked clinical radio sensitivity. In this study we investigated telomeric abnormalities of non-immortalized ...
Stable expression of promyelocytic leukaemia (PML) protein in telomerase positive MCF7 cells results in alternative lengthening of telomeres phenotype [0.03%]
端粒酶阳性MCF7细胞中促髓细胞性白血病（PML）蛋白的稳定表达导致染色体末端选择性延长表型出现
Jacklyn W Y Yong,Xiujun Yeo,Md Matiullah Khan et al.
Jacklyn W Y Yong et al.
Background: Cancer cells can employ telomerase or the alternative lengthening of telomeres (ALT) pathway for telomere maintenance. Cancer cells that use the ALT pathway exhibit distinct phenotypes such as heterogeneous te...
Processing of DNA double strand breaks by alternative non-homologous end-joining in hyperacetylated chromatin [0.03%]
组蛋白高乙酰化染色质中通过替代非同源末端连接修复DNA双链断裂
Vasilissa Manova,Satyendra K Singh,George Iliakis
Vasilissa Manova
Background: Mammalian cells employ at least two subpathways of non-homologous end-joining for the repair of ionizing radiation induced DNA double strand breaks: The canonical DNA-PK-dependent form of non-homologous end-jo...
Deficient expression of DNA repair enzymes in early progression to sporadic colon cancer [0.03%]
DNA修复酶在散发性结肠癌早期进展中的表达缺陷
Alexander Facista,Huy Nguyen,Cristy Lewis et al.
Alexander Facista et al.
Background: Cancers often arise within an area of cells (e.g. an epithelial patch) that is predisposed to the development of cancer, i.e. a "field of cancerization" or "field defect." Sporadic colon cancer is characterize...
Differential regulation of intracellular factors mediating cell cycle, DNA repair and inflammation following exposure to silver nanoparticles in human cells [0.03%]
银纳米颗粒通过调节细胞周期、DNA修复和炎症相关介质的表达来诱导人类细胞生长抑制及凋亡的区别性机制研究
Pv Asharani,Swaminathan Sethu,Hui Kheng Lim et al.
Pv Asharani et al.
Background: Investigating the cellular and molecular signatures in eukaryotic cells following exposure to nanoparticles will further our understanding on the mechanisms mediating nanoparticle induced effects. This study i...
Development and validation of 'AutoRIF': software for the automated analysis of radiation-induced foci [0.03%]
“AutoRIF”软件的开发与验证：“AutoRIF”是一款用于辐射诱导焦点自动分析的软件
Andrew McVean,Simon Kent,Alexei Bakanov et al.
Andrew McVean et al.
Background: The quantification of radiation-induced foci (RIF) to investigate the induction and subsequent repair of DNA double strands breaks is now commonplace. Over the last decade systems specific for the automatic qu...
Tyson A Clark,Kristi E Spittle,Stephen W Turner et al.
Tyson A Clark et al.
Products of various forms of DNA damage have been implicated in a variety of important biological processes, such as aging, neurodegenerative diseases, and cancer. Therefore, there exists great interest to develop methods for interrogating ...
Effects of BRCA2 deficiency on telomere recombination in non-ALT and ALT cells [0.03%]
BRCA2缺陷对非ALT和ALT细胞端粒重组的影响
Ester Sapir,Yaghoub Gozaly-Chianea,Suliman Al-Wahiby et al.
Ester Sapir et al.
Background: Recent studies suggest that BRCA2 affects telomere maintenance. Interestingly, anti cancer treatments that involve BRCA2 and telomerase individually are currently being explored. In the light of the above rece...
Differential genetic interactions between Sgs1, DNA-damage checkpoint components and DNA repair factors in the maintenance of chromosome stability [0.03%]
Sgs1、DNA损伤检查点组分和DNA修复因子在染色体稳定维持过程中的差别性基因互作关系
Lillian Doerfler,Lorena Harris,Emilie Viebranz et al.
Lillian Doerfler et al.
Background: Genome instability is associated with human cancers and chromosome breakage syndromes, including Bloom's syndrome, caused by inactivation of BLM helicase. Numerous mutations that lead to genome instability are...