Role of LET and chromatin structure on chromosomal inversion in CHO10B2 cells [0.03%]
LET及染色质结构在CHO10B2细胞中诱发染色体倒位中的作用
Ian M Cartwright,Matthew D Genet,Akira Fujimori et al.
Ian M Cartwright et al.
Background: In this study we evaluated the effect of linear energy transfer (LET) and chromatin structure on the induction of chromosomal inversion. High LET radiation causes more complex DNA damage than low LET radiation...
Augustin Luna,Mirit I Aladjem,Kurt W Kohn
Augustin Luna
An intricate network regulates the activities of SIRT1 and PARP1 proteins and continues to be uncovered. Both SIRT1 and PARP1 share a common co-factor nicotinamide adenine dinucleotide (NAD+) and several common substrates, including regulat...
Kaisa R Luoto,Ramya Kumareswaran,Robert G Bristow
Kaisa R Luoto
Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity and lead to resistance to chemotherapy and radiotherapy. Hypo...
Aging phenotypes in cultured normal human mammary epithelial cells are correlated with decreased telomerase activity independent of telomere length [0.03%]
与端粒长度无关，培养的正常人类乳腺上皮细胞衰老表型与端粒酶活性下降相关
Klara Sputova,James C Garbe,Fanny A Pelissier et al.
Klara Sputova et al.
Background: Shortening of telomeres, which are essential for maintenance of genomic integrity, is a mechanism commonly associated with the aging process. Here we ascertained whether changes in telomere lengths or telomera...
Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression [0.03%]
组蛋白H4第16位赖氨酸乙酰化位点的基因组分布及其与基因表达的关系
Nobuo Horikoshi,Pankaj Kumar,Girdhar G Sharma et al.
Nobuo Horikoshi et al.
Background: Histone post-translational modifications are critical determinants of chromatin structure and function, impacting multiple biological processes including DNA transcription, replication, and repair. The post-tr...
The shape of the radiation dose response for DNA double-strand break induction and repair [0.03%]
辐射剂量反应与DNA双链断裂的诱导和修复形状的关系
Stephen Barnard,Simon Bouffler,Kai Rothkamm
Stephen Barnard
DNA double-strand breaks are among the most deleterious lesions induced by ionising radiation. A range of inter-connected cellular response mechanisms has evolved to enable their efficient repair and thus protect the cell from the harmful c...
Analysis of telomere length and function in radiosensitive mouse and human cells in response to DNA-PKcs inhibition [0.03%]
DNA-PKcs抑制条件下放射敏感的小鼠和人体细胞中端粒长度及功能的分析
Hemad Yasaei,Yaghoub Gozaly-Chianea,Predrag Slijepcevic
Hemad Yasaei
Background: Telomeres, the physical ends of chromosomes, play an important role in preserving genomic integrity. This protection is supported by telomere binding proteins collectively known as the shelterin complex. The s...
Resolution of complex ends by Nonhomologous end joining - better to be lucky than good? [0.03%]
非同源末端连接修复复杂末端：幸运重要还是强大内切酶选择性重要？
Natasha Tiffany Strande,Crystal Ann Waters,Dale A Ramsden
Natasha Tiffany Strande
The Nonhomologous end joining pathway is essential for efficient repair of chromosome double strand breaks. This pathway consequently plays a key role in cellular resistance to break-inducing exogenous agents, as well as in the developmenta...
Pathway choice in DNA double strand break repair: observations of a balancing act [0.03%]
DNA双链断裂修复中的通路选择：平衡行为的观察
Inger Brandsma,Dik C Gent
Inger Brandsma
Proper repair of DNA double strand breaks (DSBs) is vital for the preservation of genomic integrity. There are two main pathways that repair DSBs, Homologous recombination (HR) and Non-homologous end-joining (NHEJ). HR is restricted to the ...
Gamma-H2AX foci in cells exposed to a mixed beam of X-rays and alpha particles [0.03%]
细胞混合暴露于X射线和α粒子后产生的γ-H2AX焦点反应
Elina Staaf,Karl Brehwens,Siamak Haghdoost et al.
Elina Staaf et al.
Background: Little is known about the cellular effects of exposure to mixed beams of high and low linear energy transfer radiation. So far, the effects of combined exposures have mainly been assessed with clonogenic survi...