Identification and Preliminary Validation of Radiation Response Protein(s) in Human Blood for a High-throughput Molecular Biodosimetry Technology for the Future [0.03%]
人血液辐射响应蛋白的鉴定与初步验证——未来高通量分子生物剂量检测技术研究
Saibadaiahun Nongrum,S Thangminlal Vaiphei,Joshua Keppen et al.
Saibadaiahun Nongrum et al.
The absence of a rapid and high-throughput technology for radiation biodosimetry has been a great obstacle in our full preparedness to cope with large-scale radiological incidents. The existing cytogenetic technologies have limitations, pri...
Effects of Valproic Acid on Radiation-Induced Chromosomal Aberrations in Human Lymphocytes [0.03%]
丙戊酸钠对辐射诱导的人淋巴细胞染色体损伤的影响
María Vittoria Di Tomaso,Eric Gregoire,Wilner Martínez-López
María Vittoria Di Tomaso
One of the most widely employed histone deacetylases inhibitors in the clinic is the valproic acid (VA), proving to have a good tolerance and low side effects on human health. VA induces changes in chromatin structure making DNA more suscep...
Optimizing the Microscopy Time Schedule for Chromosomal Dosimetry of High-dose and Partial-body Irradiations [0.03%]
高剂量和部分身体照射的染色体剂量学显微时间表优化
Volodymyr A Vinnikov
Volodymyr A Vinnikov
The methodology of cytogenetic triage can be improved by optimizing a schedule of microscopy for different exposure scenarios. Chromosome aberrations were quantified by microscopy in human blood lymphocytes irradiated in vitro to ~2, 4, and...
Retrospective Biological Dosimetry at Low and High Doses of Radiation and Radioiodine Impact on Individual Susceptibility to Ionizing Radiation [0.03%]
低剂量和高剂量辐射及放射性碘的回顾性生物学剂量测定及个体对离子辐射的敏感性
Antonina Cebulska-Wasilewska,Mateusz Krzysiek,Grażyna Krajewska et al.
Antonina Cebulska-Wasilewska et al.
Iodine-131 (I-131) is often used in thyroid diagnostics and therapy. External and internal exposure to radioiodine can lead to molecular and cellular damage in peripheral blood lymphocytes. The aim of this study was to explore the influence...
Assessment of Correlation between Chromosomal Radiosensitivity of Peripheral Blood Lymphocytes after In vitro Irradiation and Normal Tissue Side Effects for Cancer Patients Undergoing Radiotherapy [0.03%]
外周血淋巴细胞体外辐射染色体放射敏感性与肿瘤患者放疗正常组织损伤的相关性研究
Kamilė Guogytė,Aista Plieskienė,Rima Ladygienė et al.
Kamilė Guogytė et al.
Patients receiving identical radiation treatments experience different effects, from undetectable to severe, on normal tissues. A crucial factor of radiotherapy related side effects is individual radiosensitivity. It is difficult to spare s...
Biodosimetry of Persons Chronically Exposed to Low and Therapeutic Doses of Ionizing Radiation [0.03%]
慢性接触低剂量和治疗剂量电离辐射人群的生物剂量学研究进展
Alla Zedginidze,Ema Namchevadze,George Ormocadze et al.
Alla Zedginidze et al.
Dynamic changes of the chromosomal aberrations and the DNA damage were analyzed in individuals exposed to low and therapeutic doses of radiation. The investigation included 37 persons living in areas where the radioactive sources were disco...
Strong Correlation among Three Biodosimetry Techniques Following Exposures to Ionizing Radiation [0.03%]
三种生物剂量学方法检测离子辐射照射后的相关性分析
Chang-Mo Kang,Hyun Jin Yun,Hanna Kim et al.
Chang-Mo Kang et al.
Three in vitro dose calibration curves for biodosimetry such as dicentric chromosome assay, fluorescence in situ hybridization (FISH) assay for translocation, and micronuclei (MNs) in binucleated cell assay were established after exposure t...
Study on γH2AX Expression of Lymphocytes as a Biomarker In Radiation Biodosimetry [0.03%]
辐射生物剂量学中淋巴细胞γH2AX表达作为生物标志物的研究
Yan Pan,Gang Gao,Jian Lei Ruan et al.
Yan Pan et al.
Flow cytometry analysis was used to detect the changes of γH2AX protein expression in human peripheral blood lymphocytes. In the dose-effect study, the expression of γH2AX was detected 1 h after irradiation with 60Co γ-rays at doses of 0...
Construction of Calibration Curve for Premature Chromosome Condensation Assay for Dose Assessment [0.03%]
剂量评估的早熟染色体凝集法标曲绘制研究
Elizaveta G Neronova
Elizaveta G Neronova
Cytogenetic dosimetry plays an important role in the triage and medical management of affected people in radiological incidents/accidents. Cytogenetic biodosimetry uses different methods to estimate the absorbed dose in the exposed individu...
Establishment of Dose-response Curves for Dicentrics and Premature Chromosome Condensation for Radiological Emergency Preparedness in Thailand [0.03%]
泰国辐射应急准备工作的辐射剂量-反应关系的确立——染色体畸变和早熟染色体制备分析法的研究
Benchawan Rungsimaphorn,Budsaba Rerkamnuaychoke,Wanwisa Sudprasert
Benchawan Rungsimaphorn
The in vitro dose calibration curves using conventional biological dosimetry - dicentric chromosome assay (DCA) and premature chromosome condensation (PCC) assay - were performed for the first time in Thailand for reconstruction of radiatio...