Harnessing bone marrow mesenchymal stem cell-derived extracellular vesicles and biomimetic peptide WKYMVm in self-healing hydrogel for enhanced bone repair in femoral defects [0.03%]
利用骨髓间充质干细胞来源的外泌体和类天然多肽WKYMVM促进股骨缺损处自修复水凝胶的骨组织再生修复功能
Keyu Luo,Yufei Jin,Baiyi Liu et al.
Keyu Luo et al.
Skeletal disorders pose significant challenges to health and quality of life, underscoring the critical need for innovative bone repair methods. Recent studies have spotlighted the promising role of extracellular vesicles (EVs) derived from...
Intranasal delivery of macrophage cell membrane cloaked biomimetic drug-nanoparticle system attenuates acute lung injury [0.03%]
鼻内递送巨噬细胞膜仿生药物-纳米颗粒系统治疗急性肺损伤
Yue Zhao,Xin Shen,Yinqiang Fan et al.
Yue Zhao et al.
Acute lung injury (ALI)/acute respiratory distress syndrome (ARDS), a life-threatening disease, is typically induced by uncontrolled inflammatory responses and excessive production of reactive oxygen species (ROS). Astaxanthin (Ast) is know...
Bioinspired synthetic peptide-based biomaterials regenerate bone through biomimicking of extracellular matrix [0.03%]
仿生合成肽基生物材料通过模拟细胞外基质进行骨再生
Sareh Azadi,Mohammad Ali Yazdanpanah,Ali Afshari et al.
Sareh Azadi et al.
There have been remarkable advancements in regenerative medicine for bone regeneration, tackling the worldwide health concern of tissue loss. Tissue engineering uses the body's natural capabilities and applies biomaterials and bioactive mol...
Animal-derived free hydrolysate in animal cell culture: Current research and application advances [0.03%]
动物源性フリー低分子分解物を含む動物細胞培養の最新研究動向と応用展開
Guanghan Fan,Ying Li,Qinghua Ye et al.
Guanghan Fan et al.
Fetal bovine serum (FBS) plays a crucial role in the composition of animal cell culture medium. However, conventional serum-based medium face numerous challenges. The use of animal-derived free hydrolysate (ADFH) has garnered significant at...
Meta-analysis of proteomics data from osteoblasts, bone, and blood: Insights into druggable targets, active factors, and potential biomarkers for bone biomaterial design [0.03%]
基于破骨细胞、骨骼和血液的蛋白质组学数据的meta分析：药物作用靶点、活性因子及骨生物材料设计潜在生物标志物的新见解
Johannes R Schmidt,Klaudia Adamowicz,Lis Arend et al.
Johannes R Schmidt et al.
Non-healing bone defects are a pressing public health concern accounting for one main cause for decreased life expectancy and quality. An aging population accompanied with increasing incidence of comorbidities, foreshadows a worsening of th...
Decellularized extracellular matrix for organoid and engineered organ culture [0.03%]
用于类器官和工程器官培养的脱细胞细胞外基质
Xiaoxu Guo,Boxun Liu,Yi Zhang et al.
Xiaoxu Guo et al.
The repair and regeneration of tissues and organs using engineered biomaterials has attracted great interest in tissue engineering and regenerative medicine. Recent advances in organoids and engineered organs technologies have enabled scien...
Synthetic injectable and porous hydrogels for the formation of skeletal muscle fibers: Novel perspectives for the acellular repair of substantial volumetric muscle loss [0.03%]
用于形成骨骼肌纤维的合成可注射和多孔水凝胶：实质体积型肌肉损失无细胞修复的新视角
Louise Griveau,Marion Bouvet,Emilie Christin et al.
Louise Griveau et al.
In severe skeletal muscle damage, muscle tissue regeneration process has to face the loss of resident muscle stem cells (MuSCs) and the lack of connective tissue necessary to guide the regeneration process. Biocompatible and standardized 3D...
Advancing skin model development: A focus on a self-assembled, induced pluripotent stem cell-derived, xeno-free approach [0.03%]
推进皮肤模型开发：专注于自组装、诱导多能干细胞系来源、无异种细胞的方法
Marla Dubau,Tarada Tripetchr,Lava Mahmoud et al.
Marla Dubau et al.
The demand for skin models as alternatives to animal testing has grown due to ethical concerns and the need for accurate substance evaluation. These alternatives, known as New Approach Methodologies (NAMs), are increasingly used for regulat...
Targeting ROS in osteoclasts within the OA environment: A novel therapeutic strategy for osteoarthritis management [0.03%]
靶向骨关节炎环境中的破骨细胞ROS：骨关节炎管理的新治疗策略
Seungho Jeon,Tae Min Kim,Gitae Kwon et al.
Seungho Jeon et al.
This study investigated the therapeutic potential of a manganese dioxide-polymer dot (MnO2-PD)-incorporated hydrogel, designated as M-PD hydrogel, for modulating reactive oxygen species (ROS) within the osteoarthritis (OA) environment. Our ...
Unlocking the regenerative key: Targeting stem cell factors for bone renewal [0.03%]
解锁再生的关键：靶向干细胞因子促进骨更新
Gul Karima,Hwan D Kim
Gul Karima
Stem cell factors (SCFs) are pivotal factors existing in both soluble and membrane-bound forms, expressed by endothelial cells (ECs) and fibroblasts throughout the body. These factors enhance cell growth, viability, and migration in multipo...