A biomimetic tubuloid-on-a-chip for human renal fibrosis research and anti-fibrotic drug development [0.03%]
一种用于人类肾纤维化研究和抗纤维化药物开发的类器官芯片
Xinyu Zhang,Feili Yang,Cheng Han et al.
Xinyu Zhang et al.
Chronic kidney disease (CKD), driven largely by renal fibrosis, lacks effective therapies due to the limited predictive capacity of existing preclinical models. To address this, we developed a human tubuloid-on-a-chip model integrating tubu...
Integrating single-cell and spheroid strategies in tissue engineering: Comparative insights from pancreas, cartilage, heart and brain [0.03%]
组织工程技术中单细胞和球状体策略的整合：来自胰腺、软骨、心脏和大脑的比较见解
Shankar Shanmuga Sundaram,Michelle Min Shuen Tan,Quang Bach Le et al.
Shankar Shanmuga Sundaram et al.
Tissue engineering (TE) remains a cornerstone of regenerative medicine, aiming to bypass the limitation of organ transplantation through the fabrication of functional tissue substitutes. Traditionally, TE has followed two primary paradigms:...
Exploring the memory of the extracellular matrix using MASH-derived decellularized scaffolds [0.03%]
利用MASH脱细胞支架探索细胞外基质的记忆力
Gabriel Reis Pinto,Luana Diniz Guerra Braz,Yasmin Pestana et al.
Gabriel Reis Pinto et al.
Emerging evidence suggests that the extracellular matrix (ECM) possesses a "memory" that can influence cell physiology and recellularization outcomes. Understanding this memory is essential to allow the use of bioengineered organs derived f...
Synergistic Wnt/BMP Co-activation accelerates osteogenic differentiation of human pluripotent stem cells via paraxial mesoderm induction [0.03%]
Wnt/BMP协同激活通过旁中胚层诱导加速人多能干细胞成骨分化
Hongsik Kim,Sujin Kim,A-Hyeon Kim et al.
Hongsik Kim et al.
Bone healing is a complex and well-organized process, regulated by various factors ranging from growth factors to hormones, cytokines, mechanical stimuli, and aging. Recently, numerous techniques have been devised to efficiently induce the ...
Tissue-engineered blood vessels for clinical translation: Design logic, representative advances and persistent barriers [0.03%]
组织工程血管的临床转化：设计原理、代表性进展与持续障碍
Junjie Chen,Jiayang He,Dujiang Yang et al.
Junjie Chen et al.
Tissue-engineered blood vessels are promising alternatives for small-diameter vascular reconstruction, but clinical translation remains limited by thrombosis, compliance mismatch, delayed endothelialization and unstable host remodeling. Thi...
Mechanism-guided biomaterial strategies for intervertebral disc degeneration: Pathological heterogeneity, functional classification, and translational perspectives [0.03%]
机制指导的生物材料策略在椎间盘退变中的应用：病理异质性、功能分类和转化前景
Jianpeng Chen,Wenhao Deng,Shiran Zhou et al.
Jianpeng Chen et al.
Intervertebral disc degeneration (IVDD) is a multifactorial and clinically heterogeneous condition involving disturbances in oxidative balance, mitochondrial homeostasis, inflammatory signaling, susceptibility to regulated cell death, extra...
Engineering next-generation organoids: A review on bioprinting strategies, bioink innovations, and frontier applications [0.03%]
工程下一代类器官：生物打印策略、生物墨水创新及前沿应用综述
Defeng Sun,Xuemei Fan,Hua Sun et al.
Defeng Sun et al.
While organoids hold immense promise as in vitro three-dimensional (3D) models, their translational utility is fundamentally constrained by passive diffusion limits (>800 μm), which inevitably trigger necrotic core formation and stochastic...
Mechanical regulation of mesenchymal stem cell osteogenesis, bone matrix homoeostasis, and skeletal pathology [0.03%]
机械调控间充质干细胞成骨、骨基质稳态及骨骼病理学
Udipt R Das,Hussain Jaffery,Penelope M Tsimbouri et al.
Udipt R Das et al.
Osteogenesis is the process by which mesenchymal stem/stromal cells (MSCs) differentiate into mature osteoblasts, forming a mineralised bone matrix. This process is regulated by soluble factors, mechanical stimuli, and the extracellular mat...
Chondrocyte metabolic transition from proliferation to quiescence revealed by FLIM in postnatal mouse knee joints [0.03%]
基于小鼠膝关节的FLIM技术揭示软骨细胞代谢从增殖到静止状态的转变
Nadezda Ignatyeva,Boris Yakimov,Anastasiia D Kurenkova et al.
Nadezda Ignatyeva et al.
Adult articular cartilage chondrocytes have a limited capacity to divide compared to juvenile cells, but the mechanisms behind this decline remain unclear. This study investigates metabolic changes associated with the cessation of chondrocy...
Cell-free therapy for alopecia via the secretome of hiPSC-derived dermal papilla cells [0.03%]
利用hiPSC来源的毛乳头细胞分泌组进行脱发的体外细胞治疗
Hyesoo Hwangbo,Aoyang Pu,Wanyu Tan et al.
Hyesoo Hwangbo et al.
Alopecia is highly prevalent and debilitating, yet current drugs provide limited, reversible benefit with notable side effects. We established a rapid protocol to generate human induced pluripotent stem cell-derived dermal papilla cells (hi...