Biomaterials-based engineering of the bone microenvironment for osteoporosis therapy [0.03%]
用于骨质疏松治疗的基于生物材料的骨微环境工程
Anoop Puthiyoth Dayanandan,Nityanand Prakash,Yoshie Arai et al.
Anoop Puthiyoth Dayanandan et al.
Osteoporosis is a progressive skeletal disorder marked by an imbalance between bone resorption and formation, resulting in compromised microarchitecture and increased fracture risk. However, conventional pharmacological therapies have syste...
Noncoding RNAs in chronic wound healing: Mechanisms, exosome therapeutics, and translational frontiers [0.03%]
非编码RNA在慢性伤口愈合中的作用机制、外泌体治疗和转化前沿
Lingjing Yang,Yehui Lv
Lingjing Yang
Chronic wounds have become major clinical problems due to dysregulated inflammation, impaired angiogenesis, and abnormal extracellular matrix (ECM) remodeling. Noncoding RNA (ncRNA), including microRNA (miRNA), long noncoding RNA (lncRNA), ...
Comprehensive evaluation of cryopreserved aortic homografts: Long-term mechanical and histological preservation across human and porcine models [0.03%]
异种和同种主动脉导管保存的全面评估：人类与猪模型长期机械强度和组织学评价的对比研究
Hsien-Chi Liao,Kuan-Chuan Tsou,Wan-Ting Hung et al.
Hsien-Chi Liao et al.
This study aimed to examine the histological and mechanical effects of cryopreservation on human aortic tissues, focussing on storage duration and conditions. Assessments included smooth muscle cell integrity, elastic fibre preservation, an...
Cell surface engineering for inhibition of breast cancer cell motility through modulation of mechanotransduction and focal adhesion dynamics [0.03%]
通过调节机械转导和粘着斑动力学抑制乳腺癌细胞运动的细胞表面工程
Juyeon Kim,Gyo Jeong Gu,Sung Sik Hur et al.
Juyeon Kim et al.
Metastasis is a leading cause of mortality in breast cancer and is critically influenced by cell-extracellular matrix (ECM) interactions, mechanical forces, and cellular motility. In this study, we present a cell surface engineering approac...
IPSC-derived organoid-sourced skin cells enable functional 3D skin modeling of recessive dystrophic epidermolysis bullosa [0.03%]
基于IPSC衍生的器官体皮肤细胞可实现交界型大疱性表皮松解症的三维皮肤建模
Laura Garriga-Cerda,Alberto Pappalardo,Charlotte Y Lee et al.
Laura Garriga-Cerda et al.
Recessive dystrophic epidermolysis bullosa (RDEB) is a severe inherited skin disorder caused by mutations in COL7A1. Patient-derived induced pluripotent stem cells (iPSCs) enable the personalized study of RDEB pathogenesis and potential the...
Mesenchymal stem cells delivered via a bioactive disordered peptide-hydrogel platform modulate early inflammation and enhance skeletal repair in a polytrauma model [0.03%]
一种生物活性无序多肽水凝胶平台递送间充质干细胞可调节复合伤模型早期炎症并促进骨修复
Augustine Mark Saiz,Maryam Rahmati,Tony Daniel Baldini et al.
Augustine Mark Saiz et al.
Over 30% of polytrauma patients with bone fractures suffer from impaired healing and nonunion due to persistent systemic inflammation. Existing biologic strategies for bone repair primarily focus on osteogenesis but are not designed to modu...
Microfluidic organ-on-a-chip for modeling coronary artery disease: Recent applications, limitations and potential [0.03%]
血管芯片在冠状动脉疾病模型中的应用、局限及前景展望研究
Yanke Wang,Andong Liu,Xuting Zhang et al.
Yanke Wang et al.
Coronary artery disease (CAD) encompasses a spectrum of pathologies driven by atherosclerosis, trauma, inflammation, or other etiologies that compromise coronary morphology and function, ultimately leading to myocardial ischemia and infarct...
Asymmetric biphasic electric stimulation supports cardiac maturation and functionality [0.03%]
不对称双相电刺激支持心脏成熟和功能研究
Antonio Sileo,Stefano Gabetti,Alp Can Gülan et al.
Antonio Sileo et al.
Two-dimensional (2D) cardiac models are widely used for cardiotoxicity screening but often lack structural and functional maturity of adult native tissue. Electrical stimulation (ES) enhances in vitro maturation, yet conventional waveforms ...
Controlled spatial and temporal release of neurotrophic growth factor from genetically modified tissue engineering living scaffolds [0.03%]
遗传修饰的组织工程活性支架控制空间和时间释放神经营养生长因子
Hannah H Lee,Sam E Lien,Viviana Alpizar Vargas et al.
Hannah H Lee et al.
Peripheral nerve injuries (PNIs) affect thousands of patients yearly, often resulting in loss of function, sensation, and chronic pain. In critical-size defects, advanced surgical repair strategies often fail to restore full function. A key...
CRISPRa genome-wide screen identifies novel gene targets for osteogenic cell engineering [0.03%]
利用 CRISPRa 全基因组筛选识别成骨细胞工程新靶标基因
Jacob D Weston,Hunter Levis,Brandon Lawrence et al.
Jacob D Weston et al.
Bone tissue regeneration and fracture healing remain a significant challenge for physicians, with nonunion failures occurring in an estimated 5%-10% of bone-healing treatments. The autologous bone graft has long been the gold standard of tr...