Cell-free osteoarthritis treatment with dual-engineered chondrocyte-targeted extracellular vesicles derived from mechanical loading primed mesenchymal stem cells [0.03%]
经机械加载预处理的间充质干细胞衍生的双基因工程软骨细胞靶向外泌体的无细胞骨关节炎治疗
Peng Wang,Haiyue Zhao,Wei Chen et al.
Peng Wang et al.
Osteoarthritis (OA) is an age-related chronic inflammatory disease, predominantly characterized by chondrocyte senescence and extracellular matrix (ECM) degradation. Although mesenchymal stem cells (MSCs) derived extracellular vesicles (EVs...
Dissolving microneedle patch loaded with adipokines-enriched adipose extract relieves atopic dermatitis in mouse via modulating immune disorders, microbiota imbalance, and skin barrier defects [0.03%]
载有丰富脂肪细胞因子的溶解型微针贴片可通过调节免疫紊乱、菌群失调和皮肤屏障缺陷缓解小鼠特应性皮炎
Jingyan Guan,Kaiqi Chen,Feng Lu et al.
Jingyan Guan et al.
Atopic dermatitis (AD) is a chronic relapsing dermatosis that demands new therapies. This research group previously developed a physically extracted adipose-derived extracellular matrix named adipose collagen fragments (ACF), which was dete...
Advances in tissue engineering of peripheral nerve and tissue innervation - a systematic review [0.03%]
周围神经组织工程和组织神经化研究进展-系统性综述
Jayson Sueters,Rowan van Heiningen,Ralph de Vries et al.
Jayson Sueters et al.
Although various options are available to treat injured organs and peripheral nerves, none is without limitations. Auto- and allografts are the first choice of treatment, but tissue survival or functionality is not guaranteed due to often l...
Construction of functional tissue-engineered microvasculatures using circulating fibrocytes as mural cells [0.03%]
以循环纤维细胞作为周细胞的功能性组织工程微血管构建研究
Xiaolin Wang,Hong Tan,Harsha P Gunawardena et al.
Xiaolin Wang et al.
Mural cells are essential for maintaining the proper functions of microvasculatures. However, a key challenge of microvascular tissue engineering is identifying a cellular source for mural cells. We showed that in vitro, circulating fibrocy...
Therapeutic potential and mechanisms of umbilical cord mesenchymal stem cells differentiating into tendon cells and promotion of rotator cuff tendon-bone healing [0.03%]
脐带间充质干细胞向腱细胞分化促进肩袖肌腱-骨愈合的治疗潜力及机制研究
Youliang Shen,Yuelei Wang,Yidan Xu et al.
Youliang Shen et al.
Rotator cuff tendon injuries often lead to shoulder pain and dysfunction. Traditional treatments such as surgery and physical therapy can provide temporary relief, but it is difficult to achieve complete healing of the tendon, mainly becaus...
Bioengineering strategies targeting angiogenesis: Innovative solutions for osteonecrosis of the femoral head [0.03%]
靶向血管生成的生物工程技术：股骨头坏死的创新解决方案
Weihong Zhu,Zhenmu Xu,Ding Zhou et al.
Weihong Zhu et al.
Osteonecrosis of the femoral head (ONFH) is a prevalent orthopedic disorder characterized primarily by compromised blood supply. This vascular deficit results in cell apoptosis, trabecular bone loss, and structural collapse of the femoral h...
Oxygenation and function of endocrine bioartificial pancreatic tissue constructs under flow for preclinical optimization [0.03%]
流动下内分泌生物人工胰腺组织构建体的氧合及功能的临床前优化研究
Brenden N Moeun,Florent Lemaire,Alexandra M Smink et al.
Brenden N Moeun et al.
Islet transplantation and more recently stem cell-derived islets were shown to successfully re-establish glycemic control in people with type 1 diabetes under immunosuppression. These results were achieved through intraportal infusion which...
Innovative bioinks for 3D bioprinting: Exploring technological potential and regulatory challenges [0.03%]
用于3D生物打印的创新性生物墨水：探究技术潜力与监管挑战
Vidhi Mathur,Prachi Agarwal,Meghana Kasturi et al.
Vidhi Mathur et al.
The field of three dimensional (3D) bioprinting has witnessed significant advancements, with bioinks playing a crucial role in enabling the fabrication of complex tissue constructs. This review explores the innovative bioinks that are curre...
Advanced 3D bioprinted liver models with human-induced hepatocytes for personalized toxicity screening [0.03%]
用于个性化毒理筛选的高级3D生物打印人源诱导肝细胞肝脏模型
Yue Ma,Runbang He,Bo Deng et al.
Yue Ma et al.
The development of advanced in vitro models for assessing liver toxicity and drug responses is crucial for personalized medicine and preclinical drug development. 3D bioprinting technology provides opportunities to create human liver models...
3D bioprinting of the airways and lungs for applications in tissue engineering and in vitro models [0.03%]
用于组织工程和体外模型的气道和肺的3D生物打印技术
Yanning Zhang,Yujian Liu,Chen Shu et al.
Yanning Zhang et al.
Tissue engineering and in vitro modeling of the airways and lungs in the respiratory system are of substantial research and clinical importance. In vitro airway and lung models aim to improve treatment options for airway and lung repair and...