Extracellular vesicles: From large-scale production and engineering to clinical applications [0.03%]
extracellular vesicles：从大规模生产和工程应用到临床应用
Yuxuan Wang,Jiali Xiong,Kun Ouyang et al.
Yuxuan Wang et al.
Extracellular vesicles (EVs) have emerged as a promising strategy for treating a wide spectrum of pathologies, as they can deliver their cargo to recipient cells and regulate the signaling pathway of these cells to modulate their fate. Desp...
Development of human salivary gland cell lines for modeling radiation-induced damage in three-dimensional spheroid cultures [0.03%]
人腮腺细胞系的发育及其在三维球形培养中的放射损伤建模
Sangeeth Pillai,Jose G Munguia-Lopez,Younan Liu et al.
Sangeeth Pillai et al.
No permanent cure exists for salivary gland (SG) damage and consequent xerostomia (dry mouth) in patients undergoing radiotherapy for head and neck cancers. The lack of commercially available healthy human SG-derived cell lines has hindered...
Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systems [0.03%]
工程梯度生长因子以在芯片器官系统中驱动时空组织图案化
Timothy Hopkins,Swati Midha,Simon Grossemy et al.
Timothy Hopkins et al.
Spatial heterogeneity plays a key role in the development and function of human tissues and therefore needs to be incorporated within in vitro models to maximise physiological relevance and predictive power. Here, we developed and optimised...
Strategies to overcome the limitations of current organoid technology - engineered organoids [0.03%]
克服当前类器官技术限制的策略-工程化类器官
Xulong Fan,Kun Hou,Gaojian Liu et al.
Xulong Fan et al.
Organoids, as 3D in vitro models derived from stem cells, have unparalleled advantages over traditional cell and animal models for studying organogenesis, disease mechanisms, drug screening, and personalized diagnosis and treatment. Despite...
Construction of artificial lung tissue structure with 3D-inkjet bioprinting core for pulmonary disease evaluation [0.03%]
基于3D喷墨生物打印核心的仿生人工肺组织构建及应用研究
Weimin Wan,Xi Wang,Rongtao Zhang et al.
Weimin Wan et al.
By integrating 3D-inkjet bioprinting technology, differentiated human cells can be assembled into artificial lung tissue structure to achieve a rapid, efficient, and reproducible disease model construction process. Here, we developed a nove...
From in vivo models to in vitro bioengineered neuromuscular junctions for the study of Charcot-Marie-Tooth disease [0.03%]
从活体模型到体外生物工程神经肌肉接头用于Charcot-Marie-Tooth疾病的研宄
Camille Scherrer,Camille Loret,Nicolas Védrenne et al.
Camille Scherrer et al.
Peripheral neuropathies are disorders affecting the peripheral nervous system. Among them, Charcot-Marie-Tooth disease is an inherited sensorimotor neuropathy for which no effective treatment exists yet. Research on Charcot-Marie-Tooth dise...
Bioactivated scaffolds promote angiogenesis and lymphangiogenesis for dermal regeneration in vivo [0.03%]
生物激活支架促进血管生成和淋巴管生成以实现皮肤再生
Benedikt Fuchs,Sinan Mert,Daniel Hofmann et al.
Benedikt Fuchs et al.
Chronic wounds represent an unresolved medical challenge with significant impact for patients' quality of life and global healthcare. Diverse in origin, ischemic-hypoxic and inflammatory conditions play central roles as pathological feature...
Gum-on-a-Chip Exploring Host-Microbe Interactions: Periodontal Disease Modeling and Drug Discovery [0.03%]
芯片上的牙龈组织：建模牙周病和药物发现以探索宿主-微生物相互作用
Qin Hu,Aneesha Acharya,Ho Cheung Shum et al.
Qin Hu et al.
Periodontal disease is a pervasive and serious health issue, affecting millions globally and leading to severe oral and systemic health complications. This underscores the urgent need to thoroughly understand the complex host-microbe intera...
Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia [0.03%]
高表达H19的工程化内皮祖细胞移植促进动脉再内皮化并抑制新生内膜增生
Yanchen Ye,Lin Huang,Kangjie Wang et al.
Yanchen Ye et al.
Endothelial injury is a key factor initiating in-stent restenosis (ISR) following peripheral artery stent implantation. Genetically modified endothelial progenitor cells (EPCs) can promote reendothelialization of injured arteries and inhibi...
In vitro and ex vivo models of the oral mucosa as platforms for the validation of novel drug delivery systems [0.03%]
体外和活体内口腔粘膜模型作为新型药物递送系统验证平台的研究
Robyn A Macartney,Abijit Das,Atina G Imaniyyah et al.
Robyn A Macartney et al.
The benefit of complex 3D models to facilitate the robust testing of new drugs and drug delivery systems during the developmental stages of pharmaceutical manufacturing has recently become distinguished within the field. Recognition of this...