GDF15 promotes osteogenic differentiation of human dental pulp stem cells by activating the TGF-β/SMAD signaling pathway [0.03%]
GDF15通过激活TGF-β/SMAD信号通路促进人牙髓干细胞成骨分化
Pingmeng Deng,Bin Yang,Chuling Huang et al.
Pingmeng Deng et al.
Mesenchymal stem cell-mediated bone tissue engineering strategies, including human dental pulp stem cells (hDPSCs), represent an effective therapeutic approach for bone defect repair, particularly in maxillofacial bone defects. Growth diffe...
From niche to organoid: Engineering bone tissues through microenvironmental insights [0.03%]
从特异走向类器官：通过微环境研究工程再造骨组织
Yan Xu,Lingchao Sheng,Minmin Zhu et al.
Yan Xu et al.
The construction of bone organoids represents a transformative approach in tissue engineering, offering unprecedented opportunities for studying bone biology, disease modeling, and regenerative medicine. The intricate understanding of the s...
In vitro models of muscle spindles: From traditional methods to 3D bioprinting strategies [0.03%]
肌梭的体外模型：从传统方法到3D生物打印策略
Yuannan Kang,Deepak M Kalaskar,Darren J Player
Yuannan Kang
Muscle spindles are key proprioceptive mechanoreceptors composed of intrafusal fibres that regulate kinaesthetic sensations and reflex actions. Traumatic injuries and neuromuscular diseases can severely impair the proprioceptive feedback, y...
Retraction: Estradiol-17β [E2] stimulates wound healing in a 3D in vitro tissue-engineered vaginal wound model [0.03%]
撤稿：雌二醇-17β[E2]通过3D体外组织工程阴道伤口模型促进创伤愈合
[This retracts the article DOI: 10.1177/20417314221149207.]. © The Author(s) 2025.
Advances in biomaterial-based composite spheroid for articular cartilage regeneration [0.03%]
基于生物材料的复合球体在关节软骨再生中的研究进展
Nopphadol Udomluck,Hansoo Park,Jae Young Lee
Nopphadol Udomluck
Articular cartilage plays a crucial role in reducing friction between bones and enabling movements; however, it is frequently degraded due to persistent joint stress, aging, and osteoarthritis. As its self-repair ability is limited, various...
Enhanced cell sheet engineering through combination of single cells and spheroids on liquid interface using perfluorocarbon [0.03%]
基于全氟碳液滴界面的单细胞和类器官球优化细胞片工程技术
Ji Hye Park,Ji-Seok Han,Eun-Jung Ann et al.
Ji Hye Park et al.
Cell sheet engineering provides a scaffold-free strategy for fabricating cohesive tissue constructs, but challenges remain in maintaining structural integrity and mimicking complex tissue architectures. This study demonstrated perfluorodeca...
Comprehensive characterization of cell and tissue responses toward high hydrostatic pressure treatment: Molecular feedback and structural integrity in bone graft processing [0.03%]
高压处理的细胞和组织反应的全面特征：骨移植处理中的分子反馈和结构完整性
Henrike Loeffler,Jan-Oliver Sass,Lorena Muelders et al.
Henrike Loeffler et al.
In the field of tissue reconstruction, the development and improvement of suitable bone grafts is of increasing importance. The implementation of bone banks enables the international distribution of suitable allografts that can be used for ...
Advances in hydrogels for capturing and neutralizing inflammatory cytokines [0.03%]
用于捕获和中和炎症细胞因子的水凝胶研究进展
Hongwei Qin,Ze Li,Sicheng Li et al.
Hongwei Qin et al.
Inflammatory cytokines play a crucial role in the inflammatory response, and their aberrant expression and overproduction are closely associated with the development of many diseases. However, traditional inflammation treatment strategies a...
Lack of biochemical signalling in GelMA leads to polarity reversion in intestinal organoids independent from mechanoreciprocity [0.03%]
缺乏生化信号导致胶原酶敏感明胶甲基丙烯酸酯培养中的肠类器官独立于机感受互惠的极性逆转
Lenie Vanhove,Thomas Van Gansbeke,Bert Devriendt et al.
Lenie Vanhove et al.
Xenogeneic tumour origin and batch-to-batch variability of Engelbreth-Holm-Swarm sarcoma tumour cell-derived hydrogels (Matrigel, Cultrex) limit the biomedical application of organoids in tissue engineering. The gelatin-methacryloyl (GelMA)...
Development of a reliable method for human triple-negative breast cancer organotypic culture: Improving imaging and genomic studies in 3D cultures [0.03%]
一种可靠的人类三阴性乳腺癌器官型培养方法的开发：改善三维培养中的影像和基因组研究
Mercedes Olvera-Valencia,Verónica Garcia-Castillo,Rosalío Ramos-Payan et al.
Mercedes Olvera-Valencia et al.
Triple-negative breast cancer (TNBC) is highly aggressive and lacks targeted therapies, posing a major challenge in oncology. Traditional two-dimensional (2D) cell cultures fail to capture the tumor microenvironment's complexity, whereas th...