Regeneration of bone- and tendon/ligament-like tissues induced by gene transfer of bone morphogenetic protein-12 in a rat bone defect [0.03%]
基因转染骨形态发生蛋白-12诱导大鼠骨缺损再生形成骨和肌腱/韧带样组织
Shinji Kuroda,Nobuhiro Goto,Michiko Suzuki et al.
Shinji Kuroda et al.
Members of the bone morphogenetic protein (BMP) family have diverse physiological roles. For instance, BMP-2 stimulates osteogenesis, while BMP-12 induces the formation of tendon/ligament-like tissues. Here, we designed a study to determine...
Augmentation of bone tunnel healing in anterior cruciate ligament grafts: application of calcium phosphates and other materials [0.03%]
前交叉韧带移植骨隧道愈合的增强：含钙磷酸盐及其他材料的应用
F R Baxter,J S Bach,F Detrez et al.
F R Baxter et al.
Bone tunnel healing is an important consideration after anterior cruciate ligament (ACL) replacement surgery. Recently, a variety of materials have been proposed for improving this healing process, including autologous bone tissue, cells, a...
Jung Keun Hyun,Hae-Won Kim
Jung Keun Hyun
Spinal cord injury (SCI) is one of the major disabilities dealt with in clinical rehabilitation settings and is multifactorial in that the patients suffer from motor and sensory impairments as well as many other complications throughout the...
In vitro biocompatibility and mechanical performance of titanium doped high calcium oxide metaphosphate-based glasses [0.03%]
掺钛高钙氧化磷基玻璃的体外生物相容性和机械性能
Ensanya A Abou Neel,Wojciech Chrzanowski,George Georgiou et al.
Ensanya A Abou Neel et al.
This study challenged to produce phosphate-based glasses (PBG) for the treatment of osseous defects. The glasses contained, among other components, 40 mol% CaO and 1-5 mol% TiO(2). The mechanical performance and in vitro biocompatibility us...
Fate of bone marrow-derived stromal cells after intraperitoneal infusion or implantation into femoral bone defects in the host animal [0.03%]
骨髓基质细胞经腹腔注射或植入宿主股骨缺损中的命运考察
Timothy Wilson,Christoffer Stark,Johanna Holmbom et al.
Timothy Wilson et al.
The fate of intraperitoneally injected or implanted male rat bone marrow-derived stromal cells inside female sibling host animals was traced using Y-chromosome-sensitive PCR. When injected intraperitoneally, Y-chromosome-positive cells were...
Fibroblast growth factors: biology, function, and application for tissue regeneration [0.03%]
纤维生长因子：生物学、功能及其在组织再生中的应用
Ye-Rang Yun,Jong Eun Won,Eunyi Jeon et al.
Ye-Rang Yun et al.
Fibroblast growth factors (FGFs) that signal through FGF receptors (FGFRs) regulate a broad spectrum of biological functions, including cellular proliferation, survival, migration, and differentiation. The FGF signal pathways are the RAS/MA...
Gabrielle Farrar,Justin Barone,Abby Morgan
Gabrielle Farrar
Cell differentiation on glutaraldehyde cross-linked ovalbumin scaffolds was the main focus of this research. Salt leaching and freeze drying were used to create a three-dimensional porous structure. Average pore size was 147.84 ± 40.36 μm...
Laura E McNamara,Rebecca J McMurray,Manus J P Biggs et al.
Laura E McNamara et al.
Stem cells have the capacity to differentiate into various lineages, and the ability to reliably direct stem cell fate determination would have tremendous potential for basic research and clinical therapy. Nanotopography provides a useful t...
Insulin resistance compromises midbrain organoid neuronal activity and metabolic efficiency predisposing to Parkinson's disease pathology [0.03%]
胰岛素抵抗损害中脑类器官神经元活性和代谢效率，使其易患帕金森病病理改变
Growing evidence indicates that type 2 diabetes (T2D) is associated with an increased risk of developing Parkinson's disease (PD) through shared disease mechanisms. Studies show that insulin resistance, which is the driving pathophysiologic...
Developing human upper, lower, and deep lung airway models: Combining different scaffolds and developing complex co-cultures [0.03%]
人类上下呼吸道及肺泡组织工程模型的构建：结合不同支架材料及建立复杂共培养细胞系
Advanced in vitro models are crucial for studying human airway biology. Our objective was the development and optimization of 3D in vitro models representing diverse airway regions, including deep lung alveolar region. This initiative was a...