Asymmetric biphasic electric stimulation supports cardiac maturation and functionality [0.03%]
不对称双相电刺激支持心脏成熟和功能研究
Antonio Sileo,Stefano Gabetti,Alp Can Gülan et al.
Antonio Sileo et al.
Two-dimensional (2D) cardiac models are widely used for cardiotoxicity screening but often lack structural and functional maturity of adult native tissue. Electrical stimulation (ES) enhances in vitro maturation, yet conventional waveforms ...
Controlled spatial and temporal release of neurotrophic growth factor from genetically modified tissue engineering living scaffolds [0.03%]
遗传修饰的组织工程活性支架控制空间和时间释放神经营养生长因子
Hannah H Lee,Sam E Lien,Viviana Alpizar Vargas et al.
Hannah H Lee et al.
Peripheral nerve injuries (PNIs) affect thousands of patients yearly, often resulting in loss of function, sensation, and chronic pain. In critical-size defects, advanced surgical repair strategies often fail to restore full function. A key...
CRISPRa genome-wide screen identifies novel gene targets for osteogenic cell engineering [0.03%]
利用 CRISPRa 全基因组筛选识别成骨细胞工程新靶标基因
Jacob D Weston,Hunter Levis,Brandon Lawrence et al.
Jacob D Weston et al.
Bone tissue regeneration and fracture healing remain a significant challenge for physicians, with nonunion failures occurring in an estimated 5%-10% of bone-healing treatments. The autologous bone graft has long been the gold standard of tr...
Differential stress responses of immunoisolated human islets embedded in pancreatic extracellular matrix under static and free-fall dynamic conditions [0.03%]
静态和自由落体动态条件下包埋在胰腺细胞外基质中的免疫隔离的人类胰岛的差异应力反应
Isaura Borges-Silva,Marluce da Cunha Mantovani,Minh Danh Anh Luu et al.
Isaura Borges-Silva et al.
Pancreatic islet transplantation offers great promise for the treatment of type 1 diabetes, yet the functional decline of islets after isolation remains a major obstacle. Increasing evidence highlights the endoplasmic reticulum (ER) as a cr...
Amelioration of intervertebral disc degeneration using engineered extracellular vesicle-delivered ZDHHC5 via inhibiting PANoptosis [0.03%]
通过抑制PANoptosis利用工程化外泌体递送ZDHHC5改善椎间盘退变
Tong Chen,Helong Zhang,Songtao Lv et al.
Tong Chen et al.
Intervertebral disc degeneration (IDD) is a common condition and a leading cause of chronic low back pain, affecting millions of individuals worldwide. Human Umbilical Cord Mesenchymal Stromal Cell (hUCMSC)-derived extracellular vesicles (E...
Stage-specific cardiotoxicity induced by bisphenol A using human pluripotent stem cell-derived 2D- and 3D-cardiomyocyte models [0.03%]
应用人多能干细胞来源的二维和三维心肌细胞模型研究双酚A诱导的心脏毒性效应及阶段特异性
Soon-Jung Park,Seong Woo Choi,Yun-Gwi Park et al.
Soon-Jung Park et al.
Bisphenol A (BPA), a widely used industrial chemical with endocrine-disrupting properties, raises developmental and cardiotoxicity concerns. We established a stage-specific cardiotoxicity platform using human pluripotent stem cell (hPSC)-de...
Human three-dimensional engineered muscle tissue characterization and intramyocellular lipid modeling [0.03%]
人三维工程肌肉组织特征和肌细胞内脂质建模
Tianxin Cao,Eric Finnemore,Jon Hill et al.
Tianxin Cao et al.
Three-dimensional engineered muscle tissues (EMTs) are transformative tools for modeling skeletal muscle physiology and pathology in vitro. Here, we perform a comprehensive comparison of EMTs derived from primary human myoblasts (hP-Myo) an...
Angiogenesis induction using organoid-tissue modules: A platform for modular vessel construction [0.03%]
类器官-组织模块诱导血管生成：模块化构建血管的平台
Jin Ju Park,Eunjeong Seo,HyeRan Gwak et al.
Jin Ju Park et al.
Angiogenesis is essential for successful tissue regeneration, particularly in clinical contexts such as ischemic injury, wound healing, and reconstructive therapies. However, the establishment of functional vasculature remains a major limit...
Blood mononuclear cells induce accelerated vascular remodeling under acute inflammation in vitro [0.03%]
急性炎症条件下血液单个核细胞体外诱导血管重构加速
Raghav Soni,Manabu Shirai,Tetsuji Yamaoka et al.
Raghav Soni et al.
The plasticity of blood mononuclear cells (MCs) and their role in vascular remodeling have been the focus of many studies; however, their in vitro differentiation efficiency remains poorly understood. Herein, we demonstrate that the inflamm...
Design of an artificial natural killer cell mimicking system to target tumour cells [0.03%]
一种针对肿瘤细胞的人工自然杀伤细胞模拟系统的设计
Vaishali Chugh,Vijaya Krishna Kanala,Dagmar Quandt et al.
Vaishali Chugh et al.
NK cell mimics are assemblies of a cell membrane and a template that replicate biomimetic features and physicochemical properties, respectively. To develop this targeted drug delivery system, gelatin microspheres (cG) were fabricated using ...