Cold-stimulated browning graft fat enhances burn wound recovery through accelerating DAMP-ADSC activation [0.03%]
冷刺激诱导褐色化的移植脂肪通过加速DAMP-ADSC激活促进烧伤创面的愈合
Wenhui Ma,Zhenyu Quan,Li Jiang et al.
Wenhui Ma et al.
Suboptimal skin regeneration in patients with severe burns leads to significant trauma. Due to their favorable biological properties, fat grafts have been widely used in wound repair. The present study aimed to investigate the regenerative ...
Genetically modified bone marrow cells halt mitral cell loss by modulating inflammation and protecting against DNA damage [0.03%]
基因改造骨髓细胞通过调节炎症和保护DNA免受损伤来阻止双光子细胞的丢失
David Díaz,Eva María Baranda-Alonso,Laura Pérez-Revuelta et al.
David Díaz et al.
Cell therapy is a promising strategy for tackling neurodegenerative diseases. The most outstanding results with this approach usually involve neuroprotection of damaged neurons at risk of death, but only with limited success. Current therap...
Fibro-adipogenic progenitors enhance functional and structural properties of human 3D tissue engineered skeletal muscles [0.03%]
成纤维脂肪前体细胞增强人类三维工程化骨骼肌的功能和结构属性
Roy Augustinus,Lotte A de Ridder,Dongxu Zheng et al.
Roy Augustinus et al.
Human skeletal muscle models often lack important supportive cell types. Here we developed a co-culture three-dimensional tissue engineered skeletal muscle (3D-TESM) model by combining myogenic progenitors (MPs) with genetically-matched imm...
Engineering a skeletal muscle model to study extracellular vesicle dynamics [0.03%]
工程化构建骨骼肌模型研究细胞外囊泡动态过程
María Fernández-Rhodes,Rowan Rimington,Jacob Fleming et al.
María Fernández-Rhodes et al.
Skeletal muscle (SM) functions both mechanically and as a secretory organ, releasing myokines and extracellular vesicles (EVs) involved in myogenic regulation and inter-tissue communication. While 3D bioengineered SM models are widely used ...
Early vascularization as a key feature of muscle-in-vein grafts for peripheral nerve repair [0.03%]
早期血管化作为肌静脉移植物修复周围神经的关键特征
Federica Zen,Giulio Ferrero,Alessandro Crosio et al.
Federica Zen et al.
Peripheral nerve injuries significantly impair quality of life due to limited regenerative capacity, which is affected by factors such as neuroma formation, injury severity, scarring, and comorbidities. The Muscle-in-Vein (MIV) repair techn...
3D bioprinting of skin equivalents: Towards functional wound healing models [0.03%]
皮肤等效物的三维生物打印：功能性伤口愈合模型的研究进展
Adrian Perez-Barreto,Roxana Moscalu,Carlo Tremolada et al.
Adrian Perez-Barreto et al.
Developing physiologically relevant human skin models remains a critical challenge in regenerative medicine and disease modelling, particularly for chronic wounds that involve persistent inflammation and vascular dysfunction. Recent advance...
Adipose mesenchymal stem cell-derived nanovesicles as a therapeutic strategy for oral mucosal regeneration after chemotherapy in a rat model [0.03%]
化疗大鼠模型中脂肪间充质干细胞衍生的纳米囊泡在口腔粘膜再生中的治疗策略研究
Hyeop Oh,Deogil Kim,Sun Jun Lee et al.
Hyeop Oh et al.
Chemotherapy-induced oral mucositis (CIOM) is a debilitating complication with limited therapeutic options. Mesenchymal stem cells (MSCs) promote tissue repair through paracrine signaling, and stem cell-derived nanovesicles (SC-NVs) have em...
Dual-sprayable, multi-functional hydrogel for effective prevention of peritoneal adhesions [0.03%]
一种用于有效预防腹腔粘连的双重喷涂多功能水凝胶
Hyunjung Kim,Wonmoon Song,M Nivedhitha Sundaram et al.
Hyunjung Kim et al.
Over 90% of patients experience peritoneal adhesions after abdominal surgery, necessitating the use of anti-adhesion barriers. To effectively prevent tissue adhesions, strategies that combine physical and chemical blocking are essential. A ...
Safety and efficacy of bio-engineered, autologous dermo-epidermal skin grafts in reconstructive surgery: 1-year results of a prospective, randomized, intra-patient controlled, multicenter phase II clinical trial [0.03%]
生物工程自体真皮表皮移植物在重建手术中的安全性和有效性：一项前瞻性随机患者内对照多中心II期临床试验的1年结果
Frederique M Kemme,Anouk Pijpe,Matthea M Stoop et al.
Frederique M Kemme et al.
Extensive full-thickness defects remain challenging to reconstruct, as various techniques used, such as split-thickness skin grafts, often result in donor site morbidity and functional and cosmetic scar sequelae. This study evaluated the sa...
Evaluating the electrical stimulation of bone cells based on an induced transmembrane potential model and intracellular calcium levels [0.03%]
基于诱导跨膜电位模型和细胞内钙离子水平的骨细胞电刺激评价
Meike Bielfeldt,Lam Vien Che,Kai Budde-Sagert et al.
Meike Bielfeldt et al.
Electrical stimulation holds promise for enhancing bone healing; however, it has not yet seen widespread clinical adoption. A significant obstacle is the limited understanding of the biological mechanisms involved and the electric field par...