Alexander J Rago,Priyanka Raghavan,Lisandra Santiago-Capeles et al.
Alexander J Rago et al.
Transaminases can be strategically used in medicinal chemistry for the synthesis of chiral amine building blocks in a straightforward manner that alleviates the need for chiral preparative separations. However, selection of the commercial t...
James P Smith,Connor M Ellis,Anna M Duncan et al.
James P Smith et al.
Stimuli-responsive MRI agents enable disease-specific imaging by selectively modulating generated contrast in pathological microenvironments. To date, these moieties have been largely limited to those that respond to one specific (potential...
AgBF4-catalyzed insertion of unactivated alkynes into C-F bonds of acyl fluorides [0.03%]
氨基硼酸四氟化物催化未活化的炔烃对酰基氟化合物C-F键的插入反应
Tomoya Emmei,Mamoru Tobisu
Tomoya Emmei
We report an AgBF4-catalyzed intermolecular C-F insertion of unactivated alkynes into acyl fluorides, providing a general route to monofluoroalkenes. This transformation enables both C-F bond cleavage and reformation without activated coupl...
pH-activatable brominated pentamethine cyanine dyes for imaging-guided photodynamic immunotherapy of tumors [0.03%]
用于肿瘤光免疫治疗的pH激活型茋联五甲基氰 inequalities_dyes
Wangna Tang,Yanbing Cao,Ran Wang et al.
Wangna Tang et al.
Photodynamic therapy (PDT) has emerged as a minimally invasive antitumor strategy, yet conventional photosensitizers often suffer from off-target phototoxicity under physiological conditions. This study presents a novel pH-activatable bromi...
Direct visualization of inner-sphere electrocatalytic reactions as they occur at detachable electrochemical interfaces [0.03%]
直接可视化可分离电化学界面处发生的内球电催化反应
Xiangbiao Zeng,Peimeng Qiu,Xi Cui et al.
Xiangbiao Zeng et al.
Molecular-level observation of inner-sphere electrocatalytic reactions has remained a longstanding challenge. Although recent advances in in situ and operando mass spectrometry enable probing of complex electrochemical processes, intrinsic ...
Jingwen Yang,Lisa I Pilkington,Jadranka Travas-Sejdic
Jingwen Yang
Chronic and non-healing wounds, characterised by persistent inflammation, recurrent infections and impaired angiogenesis, remain a significant clinical and socioeconomic burden. Conductive polymers (CPs) have emerged as promising materials ...
Artificial intelligence-assisted phenotyping of drug-resistant bacteria using a monosaccharide-based fluorescent sensor array [0.03%]
基于单糖的荧光传感器阵列辅助人工智能表型分析耐药菌
Zhuo-Fan Zhang,Wen-Zhen Gui,Yi-Fan Tang et al.
Zhuo-Fan Zhang et al.
Chemical tools capable of effectively phenotyping drug-resistant bacteria can help improve therapeutic efficacy toward bacterial infections. While conventional techniques rely on labor-intensive procedures for the determination of bacterial...
Co-templating of polyoxoniobates and silicate/germanate trimer-rings in crystals and inorganic gels [0.03%]
聚氧铌酸盐与硅酸盐/锗酸盐三联体环的共模组装：晶体和无机凝胶中的反应性及其相互作用力
Makenzie T Nord,Andrew P Porter,Detcho J N Aboa et al.
Makenzie T Nord et al.
Polyoxometalate (POM) supramolecular gels are a growing family of materials, both for understanding fundamental self-assembly and fabricating flexible monolithic materials that retain the function of metal oxides. Here, we exploited the pH-...
Naoki Shida,Takuma Maekawa,Yuki Yasuno et al.
Naoki Shida et al.
Electrolytes are indispensable in electrosynthesis, yet their function is generally confined to ionic conduction. Here we show that specific association of electrolyte anions provides a powerful means to regulate the reactivity of electroge...
Reflection on "Site-specific PEGylation of proteins by a Staudinger-phosphite reaction": from protein modification to ADCs in the clinic [0.03%]
“定点蛋白聚乙二醇修饰的斯陶丁格-膦酸酯反应”述评：从蛋白质修饰到临床ADC药物
Karl T Schuppe,Christian P R Hackenberger
Karl T Schuppe
Chemoselective or bioorthogonal modification reactions resulted in several breakthrough studies that enabled the incorporation of functional modules into proteins and antibodies for basic and translational research. In 2010, we published a ...