Data-driven structural angle mining elucidates hidden design rules for hydrogen evolution single-atom electrocatalysts [0.03%]
数据驱动的结构角度挖掘阐明了氢进化单原子电催化剂的隐藏设计规则
Bingqing Ge,Yang Chen,Yidi Wu et al.
Bingqing Ge et al.
Structural distortions in modified two-dimensional transition metal dichalcogenides (MX2) influence electrocatalytic activity, yet quantitative and predictive structure-property relationships remain underdeveloped. To bridge this gap, we pe...
1-Deazainosine-impact on RNA structure and role in exploring ribozyme catalysis [0.03%]
1-脱aza肌苷-对RNA结构的影响及其在探索核酶催化中的作用
Christoph Mitteregger,Raphael Bereiter,Antoine Schramm et al.
Christoph Mitteregger et al.
Synthetic RNAs bearing deazapurine nucleobases are powerful probes for dissecting RNA-catalyzed reactions by atomic mutagenesis. Here we systematically characterize RNA containing 1-deazainosine (c1I) and compare it with inosine (I). We fir...
Diastereoselective synthesis of spiro[2. n]alkanes via intramolecular carbolithiation [0.03%]
intramolecular carbolithiation合成螺[2. n]烷烃的非对映选择性合成
Charlotte S Teschers,Cyriac Barra,Maximilian Scherübl et al.
Charlotte S Teschers et al.
Spirocycles are appealing motifs for drug design owing to their inherently rigid three-dimensional structure, but synthetic strategies to construct highly substituted spiroalkanes remain scarce. We report a highly diastereoselective protoco...
Changcheng Wei,Shaolei Gao,Liang Qi et al.
Changcheng Wei et al.
The coupling conversion of CO/CO2 (CO x ), sourced from coal, natural gas, biomass, and other carbon sources, with substrates of alcohols, ethers, olefins and alkanes to produce valuable chemicals represents an attractive catalytic route fo...
Boosting peptide half-life: enabling efficient generation of Fc-peptide conjugates [0.03%]
延长肽的半衰期：生成Fc-肽缀合物的有效方法
Mahri Park,Friederike M Dannheim,Monika A Papworth et al.
Mahri Park et al.
Therapeutic peptides constitute a valuable class of drug candidates due to their ability to modulate targets which are often considered 'undruggable' by traditional small molecule drugs. Nevertheless, many peptides suffer from extremely sho...
Surface engineering and local electron structure modulation to accelerate electroreduction of low-concentration nitrate [0.03%]
表面工程和局部电子结构调控促进低浓度硝酸盐电还原反应
Zhifeng Gao,Jianxing Liang,Mingdi Sun et al.
Zhifeng Gao et al.
Electroreduction of low-concentration nitrate is constrained due to the competitive hydrogen evolution side reaction and sluggish reaction dynamics. Herein, we present a NiFe-layered double hydroxide featuring hydrophobicity and oxygen vaca...
Identifying the impact of chemical functional groups on ionic liquid conductivity [0.03%]
识别官能团对离子液体电导率的影响
J E Umaña,N A Zawicki,Matthew A Gebbie et al.
J E Umaña et al.
Ionic liquids are non-flammable, electrochemically stable electrolytes with promise as next-generation battery electrolytes. However, strong ion correlations and deviations from classical ion transport prevent the predictive design of appli...
Pulsed electrolysis enables unexpected lactonization of bicyclobutane carboxylic acids [0.03%]
脉冲电解使 bicyclobutane 羧酸意外发生酯化反应
Anton S Makarov,Liang Yi,Bholanath Maity et al.
Anton S Makarov et al.
Anodic oxidation of bicyclobutane carboxylic acids leads to unexpected lactonization and provides access to substituted benzene bioisosteres from highly strained precursors. High selectivity was achieved under pulsed electrolysis. Mechanist...
Deep docking, part 2: an amplified DDU platform for ultra-large virtual screening [0.03%]
深度对接（二）：用于超大规模虚拟筛选的放大DDU平台
Mohit Pandey,Tanvir Sajed,Ivan Semenov et al.
Mohit Pandey et al.
The exponential growth of accessible chemical space represents a significant computational challenge for structure-based virtual screening. Hence, active-learning and machine-learning approaches, such as Deep Docking, have been introduced t...
Colour by design: tuning the solid-state emission of coronene bisimide by tailored matrices [0.03%]
设计调色：利用定制基质调节冠状双酰亚胺的固态发射光谱
Simon Soldner,Ömer E Öçal,Kazutaka Shoyama et al.
Simon Soldner et al.
A photofunctional coronene bisimide (CBI) has been equipped with two bulky terphenyl imide substituents that control self-assembly, restricting it to the formation of well-defined dimers with a remarkably high association constant of K = 3....