Elaine Harris
Elaine Harris
November 2025 saw the approval of a number of products which employ a variety of delivery technologies including Johnson and Johnson's DARZALEX FASPRO (with Haloyzyme's ENHAZE), Merck's KEYTRUDA QLEX, and Regeneron's EYLEA HD. It was also a...
Strategies to improve nasal administration of antiretroviral therapeutics for the treatment of NeuroAIDS [0.03%]
改善鼻内给药策略以增强抗逆转录病毒药物对神经艾滋病的治疗效果
Arya Bazargani,Kenneth Duong,Mohammad Hejazi et al.
Arya Bazargani et al.
HIV-associated neurocognitive disorders (HAND) persist in a significant proportion of HIV patients, despite combination antiretroviral therapy (cART), due to limited drug penetration across the blood-brain barrier (BBB) and the establishmen...
Kayla Baker,Cameron Macdonald,Todd Hoare
Kayla Baker
While ultrasound-based medical imaging is widely used in clinics, ultrasound-triggered drug delivery represents an emerging modality that takes advantage of the high tissue penetrability, general safety, and high clinical accessibility of u...
Intranasal spanlastics of coenzyme Q10-assisted midazolam nanoformulation for status epilepticus management [0.03%]
辅以辅酶Q10的咪达唑仑纳米药物经鼻给药治疗癫痫持续状态
Noorain Nadim,Ayub Ahmad Khan,Saba Khan et al.
Noorain Nadim et al.
Objective: To circumvent the blood-brain barrier (BBB), spanlastics was utilized as the drug delivery carrier. The present research focused on development and evaluation of spanlastics via intranasal route to overcome bio...
Designing and evaluation of mupirocin-bFGF co-loaded biodegradable antimicrobial gelatin-chitosan sponge for topical wound management in rat model [0.03%]
用于大鼠模型皮肤伤口局部管理的莫匹罗星-bFGF共载可降解抗菌明胶-壳聚糖海绵的设计与评价
Ishita Singha,Bani Kumar Jana,Rikynjai Kharbithai et al.
Ishita Singha et al.
Introduction: Wound dressings help to prevent the wound from being infected and allow gaseous exchange, along with absorbing excessive wound exudates. Open wounds are very prone to bacterial infection, mostly Staphylococc...
Xanthan gum regulates printability and antibiotic-release capacity of composite carboxymethyl cellulose hydrogels [0.03%]
黄原胶调节复合羧甲基纤维素水凝胶的打印性能和抗生素释放能力
Dmitry Labutin,Ekaterina Gordina,Mikhail Bozhokin et al.
Dmitry Labutin et al.
Aims: Carboxymethyl cellulose (CMC) and xanthan gum (XG) are promising polysaccharides for hydrogel fabrication in 3D bioprinting and controlled drug delivery. Due to the complex polymer structure of these hydrogels and t...
Innovative evaluation of topical simvastatin using 3D printed Franz-type cells and rheological testing [0.03%]
使用3D打印Franz型细胞和流变学测试评估局部给药西立伐他汀的创新方法
Nemanja Todorović,Veljko Krstonošić,Boris Milijašević et al.
Nemanja Todorović et al.
Introduction: Simvastatin (SIM), a commonly used lipid-lowering drug, exhibits pleiotropic effects with potential for dermatological applications. This study aimed to analyze the in vitro release and rheological propertie...
Synergistic delivery of 5-FU and thymoquinone via biogenic CaCO3 NPs in hyperglycemia-linked colorectal cancer cell [0.03%]
生物源性CaCO3纳米颗粒在高血糖相关结直肠癌细胞中协同输送5-氟尿嘧啶和藤黄醌
Prethiba K Ganasan,Norsharina Ismail,Ahmad Faizal Abdull Razis et al.
Prethiba K Ganasan et al.
Aim: This study evaluated two novel combination therapies using 5-Fluorouracil (5-FU), Thymoquinone (TQ), and cockle shell - derived calcium carbonate nanoparticles (CaCO3 NPs) against HT-29 colorectal cancer (CRC) cells ...
Formulation and characterization of lutein laden gel via nasal delivery: nasal permeation, and pharmacokinetic studies [0.03%]
一种通过鼻腔递送的含叶黄素凝胶的配制和表征：鼻黏膜渗透及药代动力学研究
Akansh Varshney,Amarjitsing Rajput,Varsha Pokharkar
Akansh Varshney
Aim: Lutein exhibits poor aqueous solubility, chemical instability, and low bioavailability following oral administration, which restricts its therapeutic use in Alzheimer's disease (AD). Hence, a lutein-laden liposomal i...
Intranasal thermosensitive gel for brain-targeted delivery of α-Cyperone-loaded solid lipid nanoparticles [0.03%]
载α-香柑内酯固脂体纳米粒脑靶向前列腺素鼻用热敏凝胶给药系统的研究
Yogesh Sonar,Devyani Mahajan,Eknath Kole et al.
Yogesh Sonar et al.
Aims: To develop and evaluate α-Cyperone (α-Cy)-loaded solid lipid nanoparticles (SLNs) incorporated into a thermosensitive in situ gel for enhanced intranasal delivery and improved neuroprotective efficacy. ...