Glutamine metabolic stress induces SLC25A6-dependent mitofission via MIC60-MIC19 complex disassembly in colorectal cancer [0.03%]
谷氨酰胺代谢压力通过MIC60-MIC19复合物解离诱导SLC25A6依赖性线粒体分裂在结直肠癌中的作用
Yinong Wang,Bingzhi Wang,Yu Liu et al.
Yinong Wang et al.
Glutamine addiction is a key metabolic vulnerability in cancer. However, the mechanisms governing the limited efficacy of glutamine metabolism inhibitor (GMI) monotherapy require further investigation. Via single-cell monitoring using a cas...
Mitochondrial AK3 inhibits nuclear β-catenin localization and its activation through enhancing mitochondrial activity [0.03%]
线粒体AK3通过增强线粒体功能抑制核β-连环蛋白定位及其活化
Muhah Jeong,Shin-Hyeon Ryu,Young-Sin Cho et al.
Muhah Jeong et al.
The aberrant Wnt/β-catenin signaling is tightly associated with developmental disorders and tumorigenesis. However, spatial regulation of cytoplasmic β-catenin with regard to its nuclear accumulation and signaling activation remains poorl...
TTLL12 counteracts BPOZ-2 to stabilize eEF1A1 and promote hepatocarcinogenesis [0.03%]
TTLL12通过对抗BPOZ-2稳定eEF1A1并促进肝癌发生发展
Kaiming Leng,Zhen Yang,Yao Liming et al.
Kaiming Leng et al.
Tubulin tyrosine ligase-like enzyme-12 (TTLL-12), belonging to the TTLL family, holds a crucial position in posttranslational tubulin modifications implicated in cancer development, making it a potential target for anti-tumor therapy. Howev...
TGF-β/SMAD4/14-3-3σ/TFEB axis promotes mesenchymal-epithelial transition and inhibits autophagy in colorectal cancer [0.03%]
TGF-β/SMAD4/14-3-3σ/TFEB轴促进结直肠癌的间质上皮转化并抑制自噬
Xiaoyan Chen,Markus Winter,Matjaz Rokavec et al.
Xiaoyan Chen et al.
14-3-3σ is a p53-inducible gene with tumor suppressive properties and SMAD4 is a transcription factor encoded by a tumor suppressor gene, which is commonly inactivated in colorectal cancer (CRC). Here, 14-3-3σ was characterized as direct ...
YY1-mediated NDUFA9 upregulation promotes NSCLC cell growth through mitochondrial and Akt-mTOR pathway modulation [0.03%]
YY1介导的NDUFA9上调通过线粒体和Akt-mTOR途径调节促进非小细胞肺癌细胞增殖
Yubo Yan,Yuge Zhao,Jun Tang et al.
Yubo Yan et al.
NSCLC remains a primary contributor to cancer-related mortality. This study comprehensively elucidates the expression and the functional role of NDUFA9 in NSCLC pathogenesis. Our initial bioinformatic analyses, drawing from TCGA and single-...
TFAM promotes mitochondrial division by increasing mitochondrial Sirt3 [0.03%]
TFAM通过增加线粒体Sirt3促进线粒体分裂
Shixian Zhai,Zihong Huang,Zewei Luo et al.
Shixian Zhai et al.
Mitochondrial transcription factor A (TFAM) plays a crucial role in mitochondrial fission beyond its canonical function in mtDNA maintenance. However, how TFAM regulates mitochondrial fission remains only partially understood. Fluorescence ...
CDC6/THBS1 accelerates pancreatic cancer progression via AKT-mediated glycolytic reprogramming [0.03%]
CDC6/THBS1通过AKT介导的糖酵解重构促进胰腺癌进展
Mengqiu Yin,Xi Chen,Ziyu Liu et al.
Mengqiu Yin et al.
Pancreatic cancer remains one of the most aggressive malignancies, characterized by early metastatic spread and intrinsic resistance to chemotherapy, which ultimately results in poor treatment outcomes. While the Cell Division Cycle 6 (CDC6...
Identification of human MLKL Cys184 and HSPBP1 Cys201 as novel cellular targets for necroptosis [0.03%]
人类MLKL Cys184和HSPBP1 Cys201是坏死性凋亡的新型细胞靶标：鉴定研究
Hongming Shao,Jiabin Wu,Qianyu Han et al.
Hongming Shao et al.
Necroptosis has been definitively confirmed as a caspase-deficient, non-apoptotic cellular mechanism that exhibits a profound connection to inflammatory disorders. The receptor-interacting protein kinase 1 (RIPK1), RIPK3, and mixed-lineage ...
HuR-mediated regulation of mTOR mRNA stability promotes the commitment of satellite cells towards myogenesis [0.03%]
HuR介导的mTOR mRNA稳定性调节可促进卫星细胞向肌细胞分化-commitment应理解为肌细胞分化的决定或倾向，而非固定不变的承诺状态。
Anne-Marie K Tremblay,Brenda Janice Sánchez,Bianca Colalillo et al.
Anne-Marie K Tremblay et al.
The RNA-binding protein HuR has been shown to promote the differentiation of cultured muscle cells into muscle fibers. HuR mediates this process by differentially regulating, at different stages of this process, mRNA targets encoding pro-my...
Methodological guidelines for P2X receptor assays and data interpretation [0.03%]
P2X受体检测方法学指导原则及数据解读指南
Dariusz C Gorecki,Elena Adinolfi,Sahil Adriouch et al.
Dariusz C Gorecki et al.
P2X receptors (P2XR) are a family of seven cation channels gated by extracellular ATP (eATP). Activation of P2XRs results in diverse cellular responses, including cell signalling, proliferation, differentiation, and death-all critically imp...