Unraveling the dual roles of MICAL2 in skeletal muscle physiology and fusion negative rhabdomyosarcoma tumor progression [0.03%]
MICAL2在骨骼肌生理和融合阴性横纹肌肉瘤肿瘤进展中的双重重塑作用解析
Ashley Wang,Nefele Giarratana,Simen Cassiman et al.
Ashley Wang et al.
Rhabdomyosarcoma (RMS) is a prevalent soft tissue sarcoma in pediatric populations characterized by dysregulated myogenesis and limited treatment options. Notably, fusion negative RMS (FN-RMS) constitutes the predominant subtype in pediatri...
LncPTEC mediated homocysteine accumulation elevates oxidative stress via UBQLN1-dependent MTHFD1 ubiquitination in DKD [0.03%]
长链非编码RNA PTEC通过UBQLN1介导的MTHFD1泛素化加重糖尿病肾病氧化应激累积高半胱氨酸的作用机制研究
Qijia Wang,Tianhui Wu,Peiling Li et al.
Qijia Wang et al.
Diabetic kidney disease (DKD) is a leading cause of end-stage kidney disease and chronic kidney disease. Oxidative stress, a key driver of renal fibrosis and a hallmark of DKD pathological changes, has been extensively studied for its role ...
ACSL3 inhibits ferroptosis in gastric cancer through the activation of unfolded protein response following endoplasmic reticulum stress [0.03%]
ACSL3通过内质网应激诱导的未折叠蛋白反应激活抑制胃癌铁死亡
Honglei Wang,Jie Jiao,Wenshuo Yang et al.
Honglei Wang et al.
The long-chain acyl-CoA synthetase (ACSL) family has been associated with tumor progression across various cancer types. However, the function of the ACSL family in gastric cancer (GC) remains poorly understood. Comprehensive investigations...
L Dorstyn,J Puccini,A Nikolic et al.
L Dorstyn et al.
Published Erratum
Cell death & disease. 2026 Jul 7;17(1):622. DOI:10.1038/s41419-026-09023-2 2026
Lactate-induced H3K4me3 histone mark promotes PLOD1-driven prostate cancer invasion [0.03%]
乳酸诱导的H3K4me3组蛋白标记促进PLOD1驱动的前列腺癌侵袭
Marta Iozzo,Luigi Ippolito,Erica Pranzini et al.
Marta Iozzo et al.
Prostate cancer (PCa) progression is strongly influenced by the metabolites available in the tumor microenvironment (TME), including lactic acid (LA), which is actively imported by PCa cells to boost mitochondrial metabolism and drive de no...
Single-cell and spatial transcriptomics map lung-adaptive metastasis programs through Exoc4, Cd36-vasculogenic mimicry, and Cxcr2 signaling in triple-negative breast cancer [0.03%]
单细胞和空间转录组揭示三阴性乳腺癌肺转移过程中Exoc4、Cd36血管生成模拟及Cxcr2信号的作用机制
Hsiao-Chen Lee,Chia-Yu Kuo,Fang-Ming Chen et al.
Hsiao-Chen Lee et al.
Triple-negative breast cancer (TNBC) is an aggressive subtype associated with high metastatic potential and poor outcomes, with lung metastasis representing one of the most frequent and life-threatening events. However, the mechanism how ce...
Soluble HER2 promotes chronic antigen-mediated CD8⁺ T-cell dysfunction and limits immunotherapy response in HER2-low triple-negative breast cancer [0.03%]
可溶性HER2促进慢性抗原介导的CD8⁺ T细胞功能障碍并限制低HER2三阴性乳腺癌的免疫治疗反应
Lanyu Jing,Zhiping Tan,Ziling Wang et al.
Lanyu Jing et al.
HER2-low triple-negative breast cancer (TNBC) has emerged as a clinically relevant subgroup with distinct therapeutic implications. However, the biological mechanisms underlying its heterogeneous response to immunotherapy remain poorly defi...
Correction: Tumor suppressor function of SHMT in a Drosophila RasV12DlgRNAi model: DNA damage and synergistic gene-nutrient interaction with PLP [0.03%]
纠正：果蝇RasV12DlgRNAi模型中肿瘤抑制因子SHMT的抑癌功能：DNA损伤以及与PLP的基因-营养协同作用
Chiara Angioli,Angelo Ferriero,Eleonora Pilesi et al.
Chiara Angioli et al.
Published Erratum
Cell death & disease. 2026 Jul 6;17(1):617. DOI:10.1038/s41419-026-08996-4 2026
Correction: The EHMT2-MBLAC2 axis suppresses ribosomal DNA transcription in response to nucleolar DNA damage [0.03%]
订正：EHMT2-MBLAC2轴在应对核仁DNA损伤时抑制核糖体DNA转录
Chenyue Wang,Qiutian Lu,Lianbao Cao et al.
Chenyue Wang et al.
Published Erratum
Cell death & disease. 2026 Jul 6;17(1):618. DOI:10.1038/s41419-026-08998-2 2026
Phase separation drives NLRP3 inflammasome activation independently of Golgi localization [0.03%]
相分离独立于高尔基体定位驱动NLRP3炎性小体活化
Yuansen Zhu,Chenchao Wei,Xiang Yin et al.
Yuansen Zhu et al.
The NLRP3 inflammasome plays a pivotal role in sterile inflammation and various diseases, yet the mechanisms underlying its activation remain elusive. Previous studies have implicated both NLRP3 Golgi localization and palmitoylation-mediate...