PPP2R2C confers radioresistance in nasopharyngeal carcinoma by suppressing ferroptosis via RPS27L stabilization [0.03%]
Jianbo Fang,Qi Yang,Luxi Yang et al.
Jianbo Fang et al.
Radiotherapy resistance remains a major obstacle in nasopharyngeal carcinoma (NPC). This study delineates the role of protein phosphatase 2 regulatory subunit B gamma (PPP2R2C) in NPC radioresistance and its underlying mechanism to identify...
Correction: miR-1260b, mediated by YY1, activates KIT signaling by targeting SOCS6 to regulate cell proliferation and apoptosis in NSCLC [0.03%]
Yang Xia,Ke Wei,Feng-Ming Yang et al.
Yang Xia et al.
Published Erratum
Cell death & disease. 2026 May 11;17(1):438. DOI:10.1038/s41419-026-08782-2 2026
Ahmed M Elshazly,Nayyerehalsadat Hosseini,Janakiram Vangala et al.
Ahmed M Elshazly et al.
Proteasome inhibitor drugs are currently used in the clinic to treat multiple myeloma and mantle cell lymphoma. These inhibitors cause accumulation of undegraded proteins, thus inducing proteotoxic stress and consequent cell death. However,...
Jia-Jie Chen,Xiao-Ren Zhu,Qian-Hui Gu et al.
Jia-Jie Chen et al.
In this study, we investigated the expression patterns, biological functions, and molecular mechanisms of Proline-rich γ-carboxylated Gla protein 1 (PRRG1) in pancreatic cancer pathogenesis. Our bioinformatics analysis revealed that PRRG1 ...
EMILIN1 emerges as a TGFβ/SETDB1-regulated secreted biomarker in Duchenne muscular dystrophy [0.03%]
Maeva Zamperoni,Laura Muraine,Minh-Y Tran et al.
Maeva Zamperoni et al.
Duchenne muscular dystrophy (DMD) is an incurable muscle-wasting disorder characterized by chronic membrane damage, inflammation, and progressive fibrosis. Fibrosis in DMD is driven by sustained TGFβ signaling, which promotes extracellular...
SPOP-mediated K27-linked non-degradative ubiquitination of KCNN3 suppressing HCC progression via the CTCF-SATB1 axis [0.03%]
Ziqing Zhan,Yidong Ge,Jiaxin Shi et al.
Ziqing Zhan et al.
The metastasis of hepatocellular carcinoma (HCC) cells remains a major obstacle to achieving favorable clinical outcomes, yet the underlying molecular mechanisms are still not fully understood. The dysregulation of ion channels is related t...
MECP2 mutations disrupt pluripotent stem cell fate through remodeling of the three-dimensional genome [0.03%]
Jing Zhou,Yizhuo Che,Xintao Jing et al.
Jing Zhou et al.
Mutations in the MECP2 gene are the primary cause of Rett syndrome, yet their mechanistic roles during early developmental stages remain poorly understood. In this study, CRISPR-Cas9 technology was applied to generate three loss-of-function...
A new perspective on mesenchymal stem cells and their derivatives in alleviating cerebral ischemia-reperfusion injury dynamically regulating mitochondrial function to remodel the immune network [0.03%]
从动态调节线粒体功能重塑免疫网络的新视角解读间充质干细胞及其衍生物对脑缺血再灌注损伤的缓解作用
Lizheng Huang,Yuqian Wang,Chunyi Li et al.
Lizheng Huang et al.
Cerebral Ischemia-Reperfusion Injury (CIRI) is a common pathological process in ischemic stroke. Its core detriment lies in the cascade of subsequent injuries triggered by blood flow restoration after cerebrovascular recanalization, primari...
OTUB2-mediated deubiquitination upregulates U2AF2 to promote colorectal cancer evasion of autophagy-ferroptosis [0.03%]
OTUB2介导的去泛素化通过上调U2AF2促进结直肠癌逃逸自噬-铁死亡现象
Xi Chen,Yanxin Qi,Qigang Nie et al.
Xi Chen et al.
Colorectal cancer (CRC) is one of the leading causes of cancer-related mortality worldwide. Ferroptosis, an iron-dependent form of programmed cell death, has emerged as a potential therapeutic target. However, the regulatory mechanisms that...
Genetic mutations governing ferroptosis sensitivity and resistance: a precision approach to cancer therapy [0.03%]
铁死亡敏感性和抵抗的遗传变异及其在癌症治疗中的精准应用
Peyman Tabnak,Mohammad Ebrahimnezhad,Zanyar HajiEsmailPoor
Peyman Tabnak
Ferroptosis, an iron-dependent programmed cell death pathway driven by lipid peroxidation, offers a transformative approach to cancer therapy by exploiting unique cellular vulnerabilities. This comprehensive review elucidates the intricate ...