TRIM26-mediated NKRF degradation drives Osimertinib resistance through SNRPD2-dependent stress granule formation in lung adenocarcinoma [0.03%]
TRIM26介导的NKRF降解通过SNRPD2依赖性应激颗粒形成驱动肺腺癌中奥希替尼耐药性的发展
Tao Wang,Hai-Yan Yang,Xing Wang et al.
Tao Wang et al.
Osimertinib is the standard first-line therapy for EGFR-mutant lung adenocarcinoma; however, the inevitable development of acquired resistance leads to disease progression and treatment failure. While established resistance mechanisms prima...
Subclonal β-catenin/YAP signaling heterogeneity accelerates ovarian cancer metastasis through a senescence-associated secretory phenotype [0.03%]
亚克隆β-连环素/YAP信号异质性通过衰老相关分泌表型加速卵巢癌转移
Sally K Y To,Yibin Yang,Zeyu Shi et al.
Sally K Y To et al.
Intratumoral heterogeneity in metastatic cancers complicates effective treatment, as distinct tumor subclones display varying drug sensitivities and metastatic capabilities, interacting through mechanisms that remain poorly understood. In t...
AURKA suppresses NCOA4-mediated ferritinophagy to enhance sorafenib resistance in hepatocellular carcinoma [0.03%]
AURKA通过抑制NCOA4介导的铁蛋白自噬来增强肝细胞癌索拉非尼耐药性
Wancui Zhu,Yilin Li,Zizhen Li et al.
Wancui Zhu et al.
Acquired resistance to sorafenib remains a major obstacle in the treatment of advanced hepatocellular carcinoma (HCC). While inducing ferroptosis represents a promising strategy to overcome this resistance, the specific molecular drivers un...
SPP1+ macrophage-driven interactions shape the tumor microenvironment in lymph node metastatic acral melanoma [0.03%]
SPP1+巨噬细胞驱动的相互作用塑造淋巴结转移肢端黑色素瘤的肿瘤微环境
Yao Liang,Yuli Zheng,Zhimou Cai et al.
Yao Liang et al.
Melanoma is a highly aggressive skin cancer with biologically distinct subtypes. Acral melanoma (AM), a rare but particularly aggressive form, often presents with lymph node (LN) metastasis at diagnosis. Despite its clinical severity, the m...
A new era of precision diagnosis and treatment for lung cancer: artificial intelligence-driven multimodal data integration and clinical applications [0.03%]
精准诊断和治疗肺癌的新时代——人工智能驱动的多模态数据整合及临床应用
Na Liu,Guohu Han,Qianhui Gu et al.
Na Liu et al.
Certain characteristics, such as high heterogeneity, a complex tumor microenvironment, metastatic potential, and drug resistance, render Lung cancer (LC) a formidable challenge for clinical management. With rapid advancements in high-throug...
TRIM25 promotes glioblastoma progression by stabilizing HIF-1α expression in normoxia through K11/K29 polyubiquitination [0.03%]
TRIM25通过K11/K29多泛素化在常氧条件下稳定HIF-1α表达从而促进胶质母细胞瘤进展
Hui Huang,Kaixiang Ni,Chenhua Li et al.
Hui Huang et al.
Glioblastoma (GBM) frequently activates hypoxia signaling even under normoxic conditions, yet the mechanism sustaining hypoxia-inducible factor-1α (HIF-1α) stability remains unclear. Here, we identify the E3 ubiquitin ligase TRIM25 as a k...
Disrupting SRSF10-dependent BCAT2 exon skipping reprograms tumor-associated macrophages and enhances anti-PD-1 efficacy in gastric cancer [0.03%]
通过干扰胃癌中SRSF10依赖性BCAT2外显子跳过，重新编程肿瘤相关巨噬细胞并增强抗PD-1疗效
Xiao-Bo Huang,Xin-Peng Yang,Hua-Long Zheng et al.
Xiao-Bo Huang et al.
Aberrant alternative splicing (AS) in cancer generates oncogenic proteomic diversity that drives tumor progression. Given the suboptimal efficacy of immune checkpoint inhibitors (ICIs) in gastric cancer (GC), the therapeutic potential of mo...
Glutamate-induced nuclear translocation of PYK2 in hippocampal neurons, interaction with MBD2, and role in cell death in a model of epilepsy [0.03%]
谷氨酸诱导的PYK2在海马神经元中的核转位及其与MBD2的相互作用和在癫痫模型中的细胞死亡的作用机制研究
Albert Giralt,Tiago Mendes,Enrica Montalban et al.
Albert Giralt et al.
Synaptic activity results in long-lasting alterations of neuronal properties, which require gene expression regulation. PYK2 is a calcium-activated non-receptor protein tyrosine kinase highly expressed in hippocampal neurons and involved in...
Enhancing platinum-based chemotherapy efficacy and safety through combination therapy-mediated remodeling of autophagic homeostasis in gastric cancer [0.03%]
通过联合治疗介导的自噬稳态重塑增强铂基化疗在胃癌中的有效性和安全性
Guangzhao Pan,Qianqian Xu,Kui Zhang et al.
Guangzhao Pan et al.
Platinum-based drugs exhibit potent anti-tumor efficacy but are limited by low bioavailability, severe toxicity, and resistance. Current therapeutic strategies lack effective solutions due to the unclear molecular mechanisms. Autophagy, wit...
c-FLIP as a master regulator of immune homeostasis and disease mechanisms [0.03%]
C-FLIP作为免疫稳态和疾病机制的主调节因子
Eliana Urbini,Annalisa Adamo,Yushu Hu et al.
Eliana Urbini et al.
Cellular FLICE (FADD-like IL-1β-converting enzyme)-inhibitory protein (c-FLIP) was discovered more than three decades ago and has since emerged as a multifunctional regulator of cell fate. Initially identified through its homology with vir...