βIII-tubulin can act as a brake on extrinsic apoptosis in pancreatic cancer [0.03%]
βIII-微管蛋白在胰腺癌中的抗凋亡作用
George Sharbeen,John Kokkinos,Grace Schulstad et al.
George Sharbeen et al.
The microtubule protein βIII-tubulin is a prognostic, pro-survival, and chemoresistance factor in multiple malignancies, including pancreatic ductal adenocarcinoma (PDAC). However, the precise survival mechanisms controlled by βIII-tubuli...
Targeting SRC enhances differentiation and promotes multifaceted cell death mechanisms in recurrent group 3 medulloblastoma [0.03%]
靶向SRC可增强复发性第3组髓母细胞瘤的分化并促进多种细胞死亡机制
Helgi Kuzmychova,Ujala Chawla,Emma Martell et al.
Helgi Kuzmychova et al.
Medulloblastoma (MB) is the most common childhood brain cancer, with Group 3 (G3) as the most aggressive subgroup, being prone to relapse and treatment resistance. A small subset of stem-like cells contributes to this recurrence, but the me...
Correction: CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5-AP-1 axis [0.03%]
订正：CDK5通过调节ERK5-AP-1轴在人类结直肠癌中充当肿瘤促进物的功能
Kangmin Zhuang,Juchang Zhang,Man Xiong et al.
Kangmin Zhuang et al.
Published Erratum
Cell death & disease. 2026 Apr 24;17(1):398. DOI:10.1038/s41419-026-08780-4 2026
CK1α agonists attenuate medulloblastoma stemness and relapse risk [0.03%]
CK1α激动剂可减弱髓母细胞瘤干细胞特性并降低复发风险
Kendell Peterson,Maria Turos-Cabal,Pritika Shahani et al.
Kendell Peterson et al.
While outcomes for most children with medulloblastoma (MB) are relatively favorable, those in the Sonic Hedgehog (SHH) subgroup with Tumor protein P53 (TP53) mutations-known as the SHHα subtype-face a much poorer prognosis. SHHα patients ...
ASPP2 inhibits hepatocellular carcinoma growth by regulating cuproptosis via mitochondrial protein lipoylation [0.03%]
ASPP2通过调节线粒体蛋白泛硫乙内酰胺化来抑制铜死亡从而抑制肝癌细胞生长
Lu Yang,Xuhui Li,Yutong Jiang et al.
Lu Yang et al.
Hepatocellular carcinoma (HCC) is a metabolically active malignancy. Cuproptosis, a copper-dependent programmed cell death pathway, has been found to be closely associated with tumor progression. Cells with strong oxidative phosphorylation ...
HOOK2 downregulation compromises the tumorigenic and stemness properties of ovarian cancer cells by increasing endoplasmic reticulum stress [0.03%]
钩状蛋白2通过增加内质网压力来削弱卵巢癌细胞的致瘤性和干性属性下调
Elisa Suárez-Martínez,Asunción Espinosa-Sánchez,Sander R Piersma et al.
Elisa Suárez-Martínez et al.
Ovarian cancer stands out as one of the tumors with a high mortality rate in women. Therefore, the search for new therapeutic targets is essential to enhance patient prognosis. There is evidence suggesting that HOOK2, an adaptor protein inv...
Nucleoporin TPR integrates MAPK signaling with mitogen-induced transcriptional programs [0.03%]
核孔蛋白TPR整合MAPK信号与增殖刺激诱导的转录程序
Jin Liu,Yifan Zheng,Yi Xiong et al.
Jin Liu et al.
The nuclear pore complex (NPC) component TPR has emerged as a multifunctional scaffold implicated in mitosis, chromatin organization, mRNA export, and genome stability. However, TPR's role in mitogenic signal transduction remains largely un...
Uncovering a role for METTL13 in malignant transformation of human hematopoietic stem cells and in the progression of pediatric leukemia [0.03%]
METTL13在人类造血干细胞恶性转化及儿童白血病进展中的作用机制研究
Sabina Enlund,Chae-Eun Lim,Isabella Hoang et al.
Sabina Enlund et al.
Post-transcriptional RNA modifications, such as N6-methyladenosine (m6A) methylation and adenosine to inosine (A-to-I) editing, are critical regulators of hematopoietic stem cell (HSC) self-renewal and differentiation, yet their precise con...
TNMD BRICHOS domain attenuates tau pathology and memory deficits in a mouse model of tauopathy [0.03%]
BRICHOS结构域通过小鼠tau病模型中的tau病理和记忆缺陷阈值效应减轻Tau病理和记忆缺损
Dandan Su,Huina Li,Lina Pan et al.
Dandan Su et al.
The aberrant aggregation of tau leads to loss of its physiological functions and gain of toxic functions, and plays a crucial role in the pathogenesis of tauopathies including Alzheimer's disease (AD). Targeting tau aggregation is considere...
Targeting PTDSS1 to modulate GSH synthesis triggers mitophagy and induces ferroptosis in esophageal squamous cell carcinoma cells [0.03%]
靶向PTDSS1调节GSH合成以触发线粒体自噬并诱导食管鳞状细胞癌细胞铁死亡
Xiao Zhang,Shurui Cao,Chenchen Zhou et al.
Xiao Zhang et al.
PTDSS1 is an emerging oncogenic protein associated with poor survival rates across various cancer types, including esophageal squamous cell carcinoma (ESCC). However, its regulatory mechanisms and therapeutic potential in ESCC remain incomp...