The PM20D1-OLE pathway induces microglia rewiring to ameliorate Alzheimer disease [0.03%]
PM20D1-OLE信号通路诱导小胶质细胞重编程以缓解阿尔茨海默病
Victoria Pozzi-Ruiz,Aida Giner de Gracia,Liliane Glauser et al.
Victoria Pozzi-Ruiz et al.
There is increasing evidence of microglia participation in Alzheimer's disease (AD), which incentives their modulation to intercept the disease. Here, we describe a new mechanism by which the recently AD-associated Peptidase M20 Domain Cont...
CD1d functions as a ligand for PIRA2 to drive macrophage activation in nonalcoholic fatty liver disease [0.03%]
CD1d作为PIRA2配体驱动非酒精性脂肪肝病巨噬细胞活化
Xiaosheng Tan,Qingwen Li,Zhibo Ma et al.
Xiaosheng Tan et al.
Liver inflammation is a key driver of nonalcoholic fatty liver disease (NAFLD) and its progressive subtype, nonalcoholic steatohepatitis (NASH). Macrophages, as central players in the innate immune response, are crucial to disease pathogene...
Pi4ka downregulation triggers Creb3l2-dependent lysosomal dysfunction to promote maladaptive tubular remodeling and immune activation in acute kidney injury [0.03%]
PI4KA下调通过CREB3L2依赖的溶酶体功能障碍促进急性肾损伤中的适应不良的管状重塑和免疫活化
Zhimin Chen,Jingzhi Xie,Chengkun Wu et al.
Zhimin Chen et al.
Acute kidney injury (AKI) is driven by maladaptive tubular responses, yet upstream regulators remain incompletely understood. Here, we identify phosphatidylinositol 4-kinase alpha (Pi4ka) as a critical determinant of proximal tubule cell (P...
Depletion of macrophages during early postnatal development leads to disrupted tooth root development and altered Gli1⁺ MSC trajectory [0.03%]
早发期间巨噬细胞的耗竭导致牙根发育障碍和Gli1⁺间充质干细胞轨迹改变
Yan Lei,Wen Li,Shiqing Wang et al.
Yan Lei et al.
Mammalian tooth development progresses through two principal stages-crown formation and root development-orchestrated by intricate interactions between the oral epithelium and neural crest-derived mesenchyme. After crown formation, Hertwig'...
Single-cell profiling reveals distinct populations of tumor-associated macrophages and metastatic tumor cells in breast cancer brain metastasis [0.03%]
单细胞测序揭示乳腺癌脑转移中独特的肿瘤相关巨噬细胞和转移性肿瘤细胞群
Haoyuan Shi,Jiaxin Chen,Zisheng Wu et al.
Haoyuan Shi et al.
Breast cancer brain metastasis (BCBM) is a major cause of breast cancer-related mortality, but the molecular mechanisms underlying its progression remain poorly understood. Here, we profiled the tumor immune microenvironment of BCBM at sing...
Cristae: bridging bioenergetic hubs and compartmental barriers in mitochondrial homeostasis [0.03%]
cristae：线粒体稳态中生物能量中心和区室屏障的纽带
Jin Rao,Qian-Qian Wan,Lei Chen et al.
Jin Rao et al.
Mitochondrial cristae are intricately folded structures of the inner mitochondrial membrane that play essential roles in cellular energy production, metabolic regulation, and compartmentalization. Far from being passive folds, cristae are d...
Gαi1 and Gαi3 mediate IL-11-induced signal transduction and are potential therapeutic targets for LUAD [0.03%]
Gαi1和Gαi3介导IL-11诱导的信号转导并可能是LUAD的潜在治疗靶点
Gaomeng Luo,Wenxuan Hu,Jian Yang et al.
Gaomeng Luo et al.
Lung adenocarcinoma (LUAD) is the main histologic subtype of lung cancer, and its incidence is on the rise. However, since the vast majority of patients are already in advanced stages at the time of diagnosis, their 5-year survival rate is ...
TCHP drives hepatocarcinogenesis through LLPS-mediated AURKA condensation and enables synergistic therapy [0.03%]
TCHP通过液-液相分离介导的AURKA凝聚促进肝癌发生发展并使其能够进行协同治疗
Jingshi Li,Yan Li,Xilang Pan et al.
Jingshi Li et al.
Liver cancer is a leading cause of cancer-related death worldwide. Centrosomal proteins play critical roles in maintaining mitotic fidelity, and their dysregulation contributes to tumorigenesis. Trichoplein (TCHP), a centrosomal protein has...
Correction: Integrative multi-omics identifies AP-1 transcription factor as a targetable mediator of acquired osimertinib resistance in non-small cell lung cancer [0.03%]
纠正：整合多组学鉴定出AP-1转录因子是非小细胞肺癌获得性奥希替尼耐药的作用靶点
Bengisu Dayanc,Sude Eris,Nazife Ege Gulfirat et al.
Bengisu Dayanc et al.
Published Erratum
Cell death & disease. 2026 Apr 24;17(1):399. DOI:10.1038/s41419-026-08740-y 2026
RHBDL2 drives lipid metabolic reprogramming in osteosarcoma via USP3-mediated deubiquitination of PPT1 [0.03%]
RHBDL2通过USP3介导的PPT1去泛素化在骨肉瘤中驱动脂质代谢重组
Li Fan,Cheng Tao,Xiangwei Zeng et al.
Li Fan et al.
Osteosarcoma (OS) is characterized by high malignancy and profound metabolic reprogramming, yet the upstream regulators of its lipid metabolic adaptations remain largely elusive. Here, we report that RHBDL2 is significantly overexpressed in...