OTUD6B-mediated K48 deubiquitination of FXR1 forms a positive feedback loop activating MEK2/ERK signaling in colorectal cancer liver metastasis [0.03%]
肠癌肝转移中OTUD6B介导FXR1去泛素化形成正反馈激活MEK2/ERK信号通路
Ying Lu,Ji Liu,Ya-Nan Li et al.
Ying Lu et al.
Liver metastasis remains a major cause of mortality in patients with colorectal cancer (CRC). Here, we identify OTUD6B, a deubiquitinating enzyme of the OTU family, as a key driver of CRC liver metastasis. OTUD6B is upregulated in metastati...
USP13 promotes enzalutamide resistance by catalyzing depolyubiquitination of PCMT1 in prostate cancer [0.03%]
USP13通过催化PCMT1去聚泛素化促进前列腺癌耐药性产生
Zhipeng Wang,Xiaoqiang Liu,Zhongqi Li et al.
Zhipeng Wang et al.
Castrate resistant prostate cancer (CRPC) is often driven by constitutively active androgen receptor and AR splicing variants that become resistant to established hormonal therapy strategies such as enzalutamide. Deubiquitinating enzymes (D...
KDM6A promotes diabetic retinopathy via H3K27me3-dependent ferroptosis in Müller cells [0.03%]
KDM6A通过H3K27me3依赖性铁死亡促进Müller细胞糖尿病视网膜病变
Yanjun Wen,Siyue Luo,Cheng Hu et al.
Yanjun Wen et al.
Diabetic retinopathy (DR), a leading cause of blindness, is driven by pathological angiogenesis and vascular leakage, but the underlying epigenetic mechanisms remain poorly defined. Here, we identify the histone demethylase KDM6A as a criti...
Metabolic adaptation to IMMT deficiency through the ATF6-PPARγ axis is contingent on TP53 mutation status in breast cancer [0.03%]
乳腺癌中代谢适应IMMT缺乏依赖于TP53突变状态通过ATF6-PPARγ轴
Li Liu,Dan Li,Zeyu Hou et al.
Li Liu et al.
Mitochondrial dysfunction and the corresponding metabolic reprogramming have been established as critical drivers of tumor progression; nevertheless, the specific molecular mechanisms have not yet been fully elucidated. In this study, we re...
Direct coupling and protective activation of DRP1 by the DNA-PKcs inhibitor KU-57788 synergizes with ferroptosis in anaplastic thyroid cancer cells [0.03%]
DNA-PKcs抑制剂KU-57788直接激活DRP1并协同促进胶质母细胞瘤细胞的铁死亡
Lingling Ding,Changtian Yin,Yehao Guo et al.
Lingling Ding et al.
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal malignancies, with limited treatment options and poor clinical outcomes. KU-57788, a selective inhibitor of DNA-dependent protein kinase catalytic subunit (DNA-PKcs...
Beyond re-epithelialization: prolonged remodeling re-establishes epithelial homeostasis in oral mucosa [0.03%]
超出上皮再生：延长的重塑重建口腔粘膜上皮稳态
Carson Joseph Walton,Tyler Thompson,Sofia Ali Syed et al.
Carson Joseph Walton et al.
Wound healing restores tissue integrity through tightly coordinated cellular and molecular programs, yet the biological processes that persist after apparent closure remain largely unexplored. Using a standardized mouse hard palate injury m...
DHODH inhibition suppresses cutaneous squamous cell carcinoma growth by the induction of differentiation through perturbation of the cellular redox balance [0.03%]
通过干扰细胞氧化还原平衡诱导分化而抑制DHODH可抑制皮肤鳞状细胞癌的生长
Ferial Khalife,Elodie Muzotte,Fatima Naji et al.
Ferial Khalife et al.
Dihydroorotate dehydrogenase (DHODH), a key enzyme in de novo pyrimidine biosynthesis, has recently emerged as a therapeutic target in various cancers. We have previously identified a pivotal role of DHODH in the initiation of cutaneous squ...
MMP8/PPAR-γ regulation of macrophage-mediated inflammatory response in the pathogenesis of acute-on-chronic liver failure [0.03%]
金属基质蛋白酶8/过氧化物酶体增殖激活受体-γ介导的巨噬细胞炎症反应在亚急性肝衰竭发病机制中的作用研究
Ying Xiao,Luyuan Ma,Xinyang Li et al.
Ying Xiao et al.
Acute-on-chronic liver failure (ACLF) is a critical syndrome marked by severe illness, rapid progression, and poor prognosis. We aimed to investigate immunoregulatory mechanisms governing macrophage function during ACLF progression and iden...
Lactic acid promotes metastasis of papillary thyroid carcinoma by enhancing CPT1A lactylation [0.03%]
乳酸通过增强CPT1A乳酰化促进乳头状甲状腺癌转移
Mingjian Zhao,Haifeng Han,Min Sun et al.
Mingjian Zhao et al.
Papillary thyroid carcinoma (PTC), the most prevalent thyroid malignancy, exhibits aggressive behavior in subsets with metastasis. Despite advances in risk stratification, biomarkers predicting metastatic potential remain limited. Here, we ...
Loss of FAM60A disrupts Sin3/HDAC control of the Hippo signaling and promotes oncogenic YAP1 activation [0.03%]
FAM60A缺失导致Sin3/HDAC对Hippo信号的调控紊乱并促进致癌性YAP1活化
Mojnu Miah,Md Nazmul Huda,Md Rafikul Islam et al.
Mojnu Miah et al.
FAM60A (also known as SINHCAF) is a subunit of the Sin3/HDAC histone deacetylase complex with established roles in chromatin remodeling, yet its broader cellular functions remain largely undefined. Using immunological, biochemical, CRISPR/C...